Multidisciplinary Research Training in Hematology

血液学多学科研究培训

• 批准号: 10377373
• 负责人: Enrico M Novelli
• 金额: $ 29.97万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10377373
• 关键词: Hematology; Interdisciplinary Study; Research Training

There is a need for an enhanced and expanded hematology research trainee pipeline to fit the changing landscape of the 21st century. Dr. Hoots and colleagues from the Division of Blood Diseases and Resources (DBDR) at extramural NHLBI reported in Blood in 2015 that “the total number of investigator-initiated (R01) grants that the NHLBI DBDR funds (almost all of which have nonmalignant hematologic science as their emphasis) has declined over the past decade, as have the number of unique R01 investigators.” They called for enhancement of trainee career development, a reinvigoration of hematology research technology and redefinition of roles of the hematology physician-scientist. The Pittsburgh Blood Science Center at the University of Pittsburgh School of Medicine has responded to the hematology training need with a full-featured training program in translational hematology science. The program combines cross-departmental strength in laboratory blood research, innovative, well-developed degree programs in clinical research and entrepreneurship, and translationally motivated hematology physician-scientist faculty research mentors with over $28 million in current fiscal year total cost NIH funding. Each trainee will attend a core T32 training structure in place already for heart, lung, vascular and sleep researchers at the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, including an intensive two- week “Fundamentals of Bench Research” course, grant writing workshops, academic survival skills conference series, reimbursed grant review program, and K-to-R transition workshop. An individualized career development plan is developed from a menu of options for research experience and degree programs to enhance their translational research skills:  Master of Science (MS) in Clinical Research from our Institute for Clinical Research Education  Master of Public Health (MPH) from our Graduate School of Public Health  Master of Science in Medical Product Engineering (MS-MPE) from our Swanson School of Engineering  Master of Business Administration (MBA) in entrepreneurship and product development from Carnegie Mellon University Tepper School of Business  FDA, NIH and American Society of Hematology externships for regulatory and infrastructure experience  In-house internships in drug development regulatory expertise  Laboratory training in translationally-oriented basic science labs  Apprenticeship with in-house leaders of multicenter clinical trials  Experience with computational biologists and other “big data” researchers  Skills for transitioning to early stage funded faculty researcher positions  Advanced scientific expertise on the role of emerging inflammatory biology on hemostasis, thrombosis, sickle cell disease and other vascular biology The research training program impact is augmented by an updated, USGME-approved hematology- concentrated clinical fellowship training program that offers training for evolving roles in health-system clinical hematology, transfusion medicine, hemostasis and thrombosis, and hematopathology.

需要加强和扩大血液学研究实习生渠道以适应不断变化的情况 21世纪的风景。 Hoots 博士和血液疾病与资源部的同事 2015 年，NHLBI 外部的 DBDR（DBDR）在《Blood》杂志上报告称，“研究者发起的总人数 (R01) 授予 NHLBI DBDR 基金（几乎所有基金都以非恶性血液学科学作为其 过去十年中，R01 调查员的数量有所减少。”他们叫 为了加强学员的职业发展，振兴血液学研究技术和 重新定义血液学医师科学家的角色。 匹兹堡大学医学院匹兹堡血液科学中心对此做出了回应 血液学培训需要转化血液学科学的全功能培训计划。这 项目结合了实验室血液研究的跨部门力量，创新、发展完善 临床研究和创业以及转化驱动的血液学学位课程 本财年 NIH 资助总额超过 2800 万美元。 每位学员都将参加针对心脏、肺、血管和睡眠的核心 T32 培训结构 匹兹堡心脏、肺、血液和血管医学研究所的研究人员，包括一个密集的两 周“基准研究基础”课程、资助写作研讨会、学术生存技能会议 系列、报销拨款审查计划和 K 到 R 过渡研讨会。 个性化的职业发展计划是根据研究经验和选择的菜单制定的 提高转化研究技能的学位课程：  我们临床研究教育学院的临床研究理学硕士 (MS)  我们公共卫生研究生院的公共卫生硕士 (MPH)  我们斯旺森工程学院的医疗产品工程理学硕士 (MS-MPE)  卡内基创业和产品开发工商管理硕士 (MBA) 梅隆大学泰珀商学院  FDA、NIH 和美国血液学会实习，获得监管和基础设施经验  药物开发监管专业知识的内部实习  面向转化的基础科学实验室的实验室培训  与多中心临床试验的内部领导一起学徒  与计算生物学家和其他“大数据”研究人员合作的经验 过渡到早期资助的教职研究员职位的技能  关于新兴炎症生物学在止血、血栓形成、 镰状细胞病和其他血管生物学 研究培训计划的影响通过更新的、经 USGME 批准的血液学增强 - 集中临床研究金培训计划，为卫生系统临床中不断变化的角色提供培训 血液学、输血医学、止血与血栓形成、血液病理学。