Multidisciplinary Research Training in Hematology

有必要加强和扩大血液学研究实习生的渠道，以适应不断变化的 21世纪的风景。胡茨博士和来自血液疾病和资源部的同事们 (DBDR)在校外NHLBI在2015年的血液报告中指出，“调查员发起的总人数(R01) NHLBI DBDR基金(几乎所有基金都以非恶性血液学为基础) 重点)在过去十年中有所下降，唯一的R01调查人员的数量也有所下降。他们打来电话 为促进见习人员的职业发展，振兴血液学研究技术和 血液学内科医生-科学家角色的重新定位。 匹兹堡大学医学院匹兹堡血液科学中心对这一事件做出回应 血液学培训需要一个功能齐全的翻译血液学培训计划。这个 项目结合了实验室血液研究的跨部门力量，创新，成熟 临床研究和创业的学位课程，以及翻译驱动的血液学 医生-科学家、教师、研究导师在本财年总共花费了NIH超过2800万美元的资金。 每个受训人员都将参加一个核心的T32训练结构，该结构已经到位，可以用于心肺血管和睡眠 匹兹堡心肺血液和血管医学研究所的研究人员，包括一个密集的两个- 每周“板凳研究基础”课程、基金写作工作坊、学术生存技能会议 系列，报销拨款审查计划，以及从K到R的过渡研讨会。 从一系列研究经验和选项中制定了个性化的职业发展计划 学位课程，以提高他们的翻译研究技能： 临床研究教育研究所临床研究理学硕士(MS) 我们公共卫生研究生院的公共卫生硕士 斯旺森工程学院医学产品工程硕士 卡内基工商管理硕士(工商管理硕士) 梅隆大学泰珀商学院 食品和药物管理局、美国国立卫生研究院和美国血液学会获得监管和基础设施经验 在药物开发监管专业方面的内部实习 面向翻译型基础科学实验室的实验室培训 与多中心临床试验的内部负责人一起学习 与计算生物学家和其他“大数据”研究人员的经验 过渡到早期资助教研员职位的技能 关于新兴炎症生物学在止血、血栓形成、 镰状细胞病和其他血管生物学 研究培训计划的影响因更新的、经USGME批准的血液学- 集中临床团契培训计划，为卫生系统临床中不断变化的角色提供培训 血液学、输血医学、止血和血栓形成以及血液病理学。

There is a need for an enhanced and expanded hematology research trainee pipeline to fit the changing landscape of the 21st century. Dr. Hoots and colleagues from the Division of Blood Diseases and Resources (DBDR) at extramural NHLBI reported in Blood in 2015 that “the total number of investigator-initiated (R01) grants that the NHLBI DBDR funds (almost all of which have nonmalignant hematologic science as their emphasis) has declined over the past decade, as have the number of unique R01 investigators.” They called for enhancement of trainee career development, a reinvigoration of hematology research technology and redefinition of roles of the hematology physician-scientist. The Pittsburgh Blood Science Center at the University of Pittsburgh School of Medicine has responded to the hematology training need with a full-featured training program in translational hematology science. The program combines cross-departmental strength in laboratory blood research, innovative, well-developed degree programs in clinical research and entrepreneurship, and translationally motivated hematology physician-scientist faculty research mentors with over $28 million in current fiscal year total cost NIH funding. Each trainee will attend a core T32 training structure in place already for heart, lung, vascular and sleep researchers at the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, including an intensive two- week “Fundamentals of Bench Research” course, grant writing workshops, academic survival skills conference series, reimbursed grant review program, and K-to-R transition workshop. An individualized career development plan is developed from a menu of options for research experience and degree programs to enhance their translational research skills:  Master of Science (MS) in Clinical Research from our Institute for Clinical Research Education  Master of Public Health (MPH) from our Graduate School of Public Health  Master of Science in Medical Product Engineering (MS-MPE) from our Swanson School of Engineering  Master of Business Administration (MBA) in entrepreneurship and product development from Carnegie Mellon University Tepper School of Business  FDA, NIH and American Society of Hematology externships for regulatory and infrastructure experience  In-house internships in drug development regulatory expertise  Laboratory training in translationally-oriented basic science labs  Apprenticeship with in-house leaders of multicenter clinical trials  Experience with computational biologists and other “big data” researchers  Skills for transitioning to early stage funded faculty researcher positions  Advanced scientific expertise on the role of emerging inflammatory biology on hemostasis, thrombosis, sickle cell disease and other vascular biology The research training program impact is augmented by an updated, USGME-approved hematology- concentrated clinical fellowship training program that offers training for evolving roles in health-system clinical hematology, transfusion medicine, hemostasis and thrombosis, and hematopathology.