Multidisciplinary Research Training in Hematology

血液学多学科研究培训

• 批准号: 10570902
• 负责人: Enrico M Novelli
• 金额: $ 30.19万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570902
• 关键词: Hematology; Interdisciplinary Study; Research Training

There is a need for an enhanced and expanded hematology research trainee pipeline to fit the changing landscape of the 21st century. Dr. Hoots and colleagues from the Division of Blood Diseases and Resources (DBDR) at extramural NHLBI reported in Blood in 2015 that “the total number of investigator-initiated (R01) grants that the NHLBI DBDR funds (almost all of which have nonmalignant hematologic science as their emphasis) has declined over the past decade, as have the number of unique R01 investigators.” They called for enhancement of trainee career development, a reinvigoration of hematology research technology and redefinition of roles of the hematology physician-scientist. The Pittsburgh Blood Science Center at the University of Pittsburgh School of Medicine has responded to the hematology training need with a full-featured training program in translational hematology science. The program combines cross-departmental strength in laboratory blood research, innovative, well-developed degree programs in clinical research and entrepreneurship, and translationally motivated hematology physician-scientist faculty research mentors with over $28 million in current fiscal year total cost NIH funding. Each trainee will attend a core T32 training structure in place already for heart, lung, vascular and sleep researchers at the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, including an intensive two- week “Fundamentals of Bench Research” course, grant writing workshops, academic survival skills conference series, reimbursed grant review program, and K-to-R transition workshop. An individualized career development plan is developed from a menu of options for research experience and degree programs to enhance their translational research skills:  Master of Science (MS) in Clinical Research from our Institute for Clinical Research Education  Master of Public Health (MPH) from our Graduate School of Public Health  Master of Science in Medical Product Engineering (MS-MPE) from our Swanson School of Engineering  Master of Business Administration (MBA) in entrepreneurship and product development from Carnegie Mellon University Tepper School of Business  FDA, NIH and American Society of Hematology externships for regulatory and infrastructure experience  In-house internships in drug development regulatory expertise  Laboratory training in translationally-oriented basic science labs  Apprenticeship with in-house leaders of multicenter clinical trials  Experience with computational biologists and other “big data” researchers  Skills for transitioning to early stage funded faculty researcher positions  Advanced scientific expertise on the role of emerging inflammatory biology on hemostasis, thrombosis, sickle cell disease and other vascular biology The research training program impact is augmented by an updated, USGME-approved hematology- concentrated clinical fellowship training program that offers training for evolving roles in health-system clinical hematology, transfusion medicine, hemostasis and thrombosis, and hematopathology.

有必要加强和扩大血液学研究实习生管道，以适应不断变化的 21世纪世纪的风景。Hoots博士和来自血液疾病和资源部的同事们 （DBDR）在2015年的《血液》杂志上报告说，“由透析器启动的（R 01） NHLBI DBDR基金（几乎所有这些基金都以非恶性血液学科学作为其 在过去的十年中，R 01研究人员的数量也有所下降。他们称 促进受训人员的职业发展，重振血液学研究技术， 重新定义血液科医生-科学家的角色。 匹兹堡大学医学院的匹兹堡血液科学中心已经对 血液学培训需要一个功能齐全的培训计划，在转化血液学科学。的 该计划结合了实验室血液研究的跨部门力量，创新，完善 临床研究和创业学位课程，以及学术动机的血液学 在本财政年度，拥有超过2800万美元的医生-科学家教师研究导师的费用总额超过了NIH的资金。 每个受训者将参加一个核心的T32培训结构已经到位的心脏，肺，血管和睡眠 匹兹堡心脏，肺，血液和血管医学研究所的研究人员，包括一个密集的两个， 一周的“实验室研究基础”课程，资助写作研讨会，学术生存技能会议 系列，报销赠款审查计划，和K到R过渡研讨会。 个性化的职业发展计划是从研究经验的选择菜单中制定的， 学位课程，以提高他们的翻译研究技能： 临床研究教育学院临床研究理学硕士（MS） 公共卫生硕士（MPH）从我们的公共卫生研究生院 斯旺森工程学院医学产品工程理学硕士（MS-MPE） 卡内基商学院工商管理硕士（MBA），创业和产品开发 梅隆大学泰珀商学院 获得FDA、NIH和美国血液学会的监管和基础设施经验 药物开发监管专业知识的内部实习 实验室培训在面向实践的基础科学实验室 与多中心临床试验的内部领导者一起学习 与计算生物学家和其他“大数据”研究人员的经验 过渡到早期阶段资助的教师研究员职位的技能 关于新兴炎症生物学对止血、血栓形成的作用的先进科学专业知识， 镰状细胞病和其他血管生物学 研究培训计划的影响是由一个更新的，USGME批准的血液学增强- 集中的临床研究金培训计划，为卫生系统临床中不断发展的角色提供培训 血液学、输血医学、止血和血栓形成以及血液病理学。

项目成果

Recombinant vs plasma-derived von Willebrand factor to prevent postpartum hemorrhage in von Willebrand disease.

重组与血浆衍生的血管性血友病因子预防血管性血友病产后出血。

• DOI: 10.1182/bloodadvances.2020002046
• 发表时间: 2020
• 期刊: Blood advances
• 影响因子: 7.5
• 作者: Machin,Nicoletta;Ragni,MargaretV
• 通讯作者: Ragni,MargaretV