Using Digital Tools to Understand Contexts and Consequences of High-THC Cannabis Use

项目摘要/摘要 本次K01指导研究科学家发展奖的总体目标是确定 在高THC大麻产品使用、不良反应和数字健康信息交换之间，通过 将在线论坛对话与原创定性访谈相结合的方法分析 定量调查数据收集。使用新出现的高THC大麻产品，包括食用和 浓缩物可能会导致意外摄入过多的THC，并可能产生不良反应。同时， 这些新产品通常不涉及燃烧和吸入相关副产品(如烟熏 大麻)，因此可能被认为是更安全的。在这个不断发展的大麻使用时代，新的和有经验的 大麻使用者正在转向在线场所，以获取个人生成的信息并分享他们的 经历。拟议项目的培训目标是培养混合方法分析方面的专门知识 文本数据和药物流行病学，并在数字健康信息交换和 以用户为中心研究设计策略。具体目标是：(目标1)找出以下方面的知识差距 通过对问题和经验进行文本分析，实现高THC大麻产品的使用 2010年至2018年用户生成的内容发布在线大麻和阿片社区的数据集； (目标2)描述使用高THC大麻产品的动机和背景，以及促进者和障碍 通过与大麻行业关键线人进行深入访谈来寻找在线健康信息 (n=20)和使用成人的高THC大麻(N=20)；(目标3)确定 高THC大麻产品使用和不良影响概况、其他物质使用的新模式，以及 通过对不同地理位置的美国人进行在线调查(N=2000)来使用数字技术 使用新型大麻产品的成年人。拟议的研究方案和培训将支持候选人的 在数字健康和快速发展的交汇点上发展成为独立的调查者 物质使用研究。该项目和培训计划将为未来拟定的提案提供试点数据 并测试数字健康资源，以最大限度地减少与高THC大麻使用相关的不良影响。

PROJECT SUMMARY/ABSTRACT The overall goal of this K01 Mentored Research Scientist Development Award is to determine the relationships between high-THC cannabis product use, adverse effects, and digital health information exchange by combining mixed methods analysis of online forum conversations and original qualitative interview and quantitative survey data collection. Use of emerging high-THC cannabis products including edibles and concentrates may result in too much unintended THC intake and potentially adverse effects. At the same time, these new products do not typically involve combustion and inhalation of related byproducts (as smoked cannabis does) and so may be perceived as safer. In this evolving era of cannabis use, new and experienced cannabis users are turning to online venues to access peer-generated information and to share their experiences. The training goals of the proposed project are to develop expertise in mixed methods analysis of text data and pharmaco-epidemiology and to gain experience with digital health information exchange and user-centered study design strategies. The Specific Aims are to: (Aim 1) Identify gaps in knowledge regarding high-THC cannabis product use by applying text analysis to questions and experiences extracted from a dataset of user generated content posts an online cannabis and opioid communities from 2010 through 2018; (Aim 2) Describe motivations and contexts for using high-THC cannabis products and facilitators and barriers to finding online health information by conducting in-depth interviews with cannabis industry key informants (N=20) and with high-THC cannabis using adults (N=20); (Aim 3) Determine the relationships between emerging patterns of high-THC cannabis product use and adverse effect profiles, other substance use, and digital technology use by conducting an online survey (N=2000) with a geographically diverse U.S. sample of novel cannabis product-using adults. The proposed research program and training will support the candidate’s development into an independent investigator at the rapidly developing intersection of digital health and substance use research. This project and training plan will provide pilot data for a future proposal to develop and test a digital health resource for minimizing adverse effects associated with high-THC cannabis use.