Biorepository & Tissue Analysis Shared Resource

生物样本库

• 批准号: 10377465
• 负责人: STEVEN L. CARROLL
• 金额: $ 5.95万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10377465
• 关键词: Address; Advanced Malignant Neoplasm; African American; Animal Model; Applications Grants; Area; Biological Specimen Banks; Biology; Blood; Cancer Center; Cancer Center Support Grant; Cancer Patient; Cells; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Conceptions; Consent; Cooperative Human Tissue Network; Custom; DNA; Data; Department chair; Development; Doctor of Philosophy; Emerging Technologies; Evaluation; Freezing; Funding; Future; Goals; Hematologic Neoplasms; Histologic; Histopathology; Human; Image; Immune; Institutional Review Boards; Island; Laboratories; Lead; Leadership; Link; Lipids; Malignant Neoplasms; Medical; Medicine; Microarray Analysis; Neurofibromatoses; Neurofibromatosis 1; Oncogenes; Pathologist; Pathology; Patients; Pattern; Play; Polysaccharides; Population Heterogeneity; Positioning Attribute; Predisposition; Prevention; Protein Glycosylation; Proteins; Protocols documentation; Publications; Publishing; RNA; Regimen; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Science; Sea; Services; Signal Transduction; Solid Neoplasm; Source; South Carolina; Specimen; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Strategic Planning; System; Techniques; Therapeutic; Tissue Donors; Tissue Microarray; Tissue Model; Tissue Stains; Tissue imaging; Tissues; Translational Research; Tumor Biology; Tumor Tissue; Universities; Work; animal tissue; anticancer research; base; biobank; cellular imaging; clinical diagnosis; cost effectiveness; data acquisition; data repository; drug development; drug efficacy; early onset; ethnic diversity; experimental analysis; falls; follow-up; histological specimens; histological stains; human tissue; improved; insight; instrumentation; interest; lipidomics; liquid crystal polymer; meetings; molecular imaging; multiplexed imaging; new technology; patient derived xenograft model; pre-clinical research; programs; racial diversity; repository; research study; sugar; symposium; technology development; tumor

BIOREPOSITORY & TISSUE ANALYSIS SHARED RESOURCE: SUMMARY The Hollings Cancer Center (HCC) Biorepository & Tissue Analysis (BTA) Shared Resource provides investi- gators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource com- prises several integrated services such as a biospecimen and data repository; customized and readily availa- ble tissue microarrays; RNA and DNA extractions; research pathology services, including histologic analysis of fixed, frozen, and stained tissues; and analysis of experimental results. The BTA partners with the Lipidomics Shared Resource to introduce novel technologies for spatially profiling and imaging proteins, lipids, and gly- cans in patient tumor tissues. By linking histopathology to the characterization of lipid, sugar, and protein ex- pression in tissues of clinical interest, the BTA opens the opportunity for HCC investigators to revolutionize tu- mor tissue analysis and identify previously unrecognized therapeutic avenues. Since 2013, the BTA has collected more than 26,500 cancer-associated biospecimens from patients with solid tumors and hematological malignancies, all of which are annotated and linked to clinical data. A notable fea- ture of the BTA is its ability to tailor the accrual of specimens to meet specific needs of HCC investigators. Cur- rently, 25% of BTA tissue donors are African American patients, who are typically underrepresented in biore- positories and in cancer research. During the current funding period, the BTA supported the research of 49 HCC investigators, resulting in 30 publications and 20 funded grant applications. The BTA has made impactful contributions to advance cancer research at HCC, including the identification of specimens from underserved patients with Sea Island ancestry and the use of MALDI imaging to study protein glycosylation patterns in can- cer. In addition to serving a growing group of HCC investigators, the BTA contributes to major national biore- pository efforts, including the NCI-funded Patient-Derived Xenograft (PDX) Repository, the NCI-funded Coop- erative Human Tissue Network, and the DOD-funded multi-center NCORP Racially and Ethnically Diverse Early Onset Repository. Under the leadership of Steven L. Carroll, MD, PhD, an expert in the autosomal domi- nant tumor susceptibility syndrome neurofibromatosis type 1, the BTA has become an ethnically rich and di- verse tumor tissue biorepository that serves as an important scientific resource for HCC investigators inter- ested in linking basic biology findings to the prevention, clinical diagnosis, and treatment of human cancer.

生物信息库与组织分析共享资源：综述 霍林斯癌症中心(HCC)生物信息库和组织分析(BTA)共享资源提供了研究- 鳄鱼可以接触到精心收集和注释的人类标本，以及先进的人类和 需要最先进的仪器和专业知识的动物组织分析。共享资源COM- 提供几项集成服务，如生物样品和数据存储库；定制并随时可用- 组织芯片；RNA和DNA提取；研究病理学服务，包括组织学分析 固定、冷冻、染色的组织；实验结果分析。BTA与脂质组学合作 共享资源，介绍蛋白质、脂类和甘氨酸的空间图谱和成像新技术- 患者肿瘤组织中的罐头。通过将组织病理学与脂类、糖和蛋白质的特征联系起来-- 在临床感兴趣的组织中，BTA为肝细胞癌研究人员提供了革命性的治疗肿瘤的机会。 MOR组织分析和确定以前未被认识的治疗途径。 自2013年以来，BTA已经从固体肿瘤患者那里收集了超过26,500份与癌症相关的生物显微镜 肿瘤和血液系统恶性肿瘤，所有这些都有注释并与临床数据联系起来。一个值得注意的壮举- BTA的真正用处在于它有能力根据肝细胞癌研究人员的具体需求来定制标本的数量。Cur- 目前，25%的BTA组织捐赠者是非洲裔美国人患者，他们在比奥尔的代表性通常较低- 以及癌症研究中的应用。在目前的资助期间，BTA支持了49项研究 研究人员，结果发表了30份出版物和20份资助赠款申请。BTA已经产生了影响 对推进肝细胞癌癌症研究的贡献，包括鉴定未得到充分服务的标本 有海岛血统的患者和使用MALDI成像研究CAN-C蛋白糖基化模式 CER。除了为越来越多的肝癌调查人员提供服务外，BTA还为主要的国家生物矿藏做出了贡献- 后期工作，包括NCI资助的患者衍生异种移植(PDX)存储库，NCI资助的Coop- 创新型人体组织网络，以及国防部资助的种族和民族多元化的多中心NCORP 早发库。在史蒂文·L·卡罗尔博士的领导下，他是一位常染色体领域的专家。 由于不是肿瘤易感综合征1型神经纤维瘤病，BTA已成为一种种族丰富和 作为肝癌研究人员重要科学资源的Verse肿瘤组织生物库 致力于将基本生物学发现与人类癌症的预防、临床诊断和治疗联系起来。