Core: Biorepository and Clinical Trial Office Shared Resource

核心：生物样本库和临床试验办公室共享资源

• 批准号: 10911643
• 负责人: STEVEN L. CARROLL
• 金额: $ 2.22万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10911643
• 关键词: Academic Medical Centers; Address; African ancestry; Biological; Black Populations; Blood; Breast Cancer Patient; Cancer Center; Caring; Clinical; Clinical Research; Clinical Trials; Communities; Data; Development; Enrollment; Ethnic Origin; Faculty; Funding; Future; Goals; Health Services Research; Infrastructure; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Medical center; Minority; Morbidity - disease rate; Outcome; Patients; Population Heterogeneity; Provider; Quality of life; Research; Research Personnel; Research Project Grants; Resource Sharing; South Carolina; Specimen; Survivors; Tissues; Universities; anticancer research; biobank; cancer care; cancer health disparity; care delivery; clinical center; clinical trial implementation; community setting; ethnic diversity; implementation facilitation; improved; mortality; outcome disparities; patient oriented; patient population; racial diversity; racial minority; research study; rural area

BIOREPOSITORY AND CLINICAL TRIALS OFFICE SHARED RESOURCE SUMMARY The establishment and implementation of the South Carolina Cancer Disparities Research Center (SC CADRE) Biorepository/Clinical Trials Office (CTO) Shared Resource is expected to significantly expand the research capacity of the SC CADRE investigators at South Carolina State University (SCSU), thus enhancing their ability to compete for independent, R01-level funding. This new, dual-component Shared Resource will also augment SCSU's ability to attract additional junior faculty researchers who will have access to biospecimens from racially and ethnically diverse patient populations as well as to clinical trials infrastructure at the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC). The overarching goal of the Biorepository/CTO Shared Resource is to support the development of cancer research at SCSU through both a Biorepository component and a CTO component. The Biorepository component will give SC CADRE investigators access to the RMC-MCC's patient blood and tissue specimens that were previously unavailable for research due to the lack of a biorepository infrastructure. Likewise, the CTO component will facilitate the implementation of clinical trials, providing an infrastructure for SCSU investigators to conduct research in their Orangeburg, SC community as well as providing the Orangeburg community immediate access to other NCI- approved clinical trials which have not been available to date. This Shared Resource will support the implementation of two initial SC CADRE clinical trials in Years 1-3 which will provide the biological and outcomes data needed to evaluate the hypothesized relationships that are being assessed in each of the three initial SC CADRE Full and Pilot Research Projects. Additionally, this Biorepository/CTO Shared Resource will support future SC CADRE Full and Pilot Research Projects as well as other NCI-approved clinical research studies at the RMC-MCC, with the goal of enhancing participation of diverse populations in cancer clinical research.

生物信息库和临床试验办公室共享资源 摘要 南卡罗来纳州癌症差异研究中心(SC)的建立和实施 干部)生物资料库/临床试验办公室(CTO)共享资源预计将显著扩展 南卡罗来纳州立大学自然科学干部调查员的研究能力，从而提高了 他们有能力竞争独立的、R01级的资金。这一新的双组件共享资源将 还增强了南加州大学吸引更多初级教员研究人员的能力，这些研究人员将有机会 来自不同种族和民族的患者群体的生物样本以及临床试验基础设施 奥兰治堡马布里癌症中心地区医疗中心(RMC-MCC)。的首要目标是 生物库/CTO共享资源是通过两者支持华南理工大学癌症研究的发展 一个生物库组件和一个CTO组件。生物库组件将为SC干部提供 调查人员获取RMC-MCC患者的血液和组织样本，这些样本以前是无法获得的 由于缺乏生物储存库基础设施，可用于研究。同样，CTO组件将促进 临床试验的实施，为华南理工大学的研究人员提供了一个基础设施 南卡罗来纳州奥兰治堡社区，并为奥兰治堡社区提供直接访问其他NCI- 到目前为止尚未获得批准的临床试验。此共享资源将支持 在1-3年内实施两个初步的SC干部临床试验，将提供生物和 结果数据需要评估这三项中每一项正在评估的假设关系 最初的SC干部全员和试点研究项目。此外，该生物库/CTO共享资源将 支持未来的SC干部全面和试点研究项目以及其他NCI批准的临床研究 RMC-MCC的研究，目的是加强不同人群对癌症临床的参与 研究。