Pilot & Feasibility Program

项目摘要 我们德克萨斯医疗中心消化疾病中心(简称DDC)最重要的计划之一是 试点和可行性(P/F)计划。P/F计划的目标是提供发展资金以支持 (1)年轻研究人员开始从事胃肠(GI)研究，或(2)促进胃肠研究的发展- 德克萨斯医学杂志非胃肠道相关领域的初级教员和资深研究人员的相关研究 中心。这是通过支持调查员发起的科学研究来开发初步数据来实现的 用于新的研究项目。研究地理信息相关领域的新方法补充了我们的 中心是受到鼓励的。奖项的颁发遵循了严格的同行评审制度，其中包括最初的 科学审查委员会，包括发改委内部咨询委员会对科学功绩的评价 德克萨斯医学中心的成员和临时科学家，以及我们DDC的外部顾问。这个核心 有很强的成就记录。在过去的10年里，我们支持了68名P/F受助人，其中 41个已获得40,172,685美元的外部直接费用供资，成功率为60%， DDC基金的投资回报率(ROI)为23倍。我们要求在16-20年内每年提供100,000美元 继续这个PF计划。这笔资金每年都将因以下方面的额外承诺而显著增加 我们的三个支持机构，包括德克萨斯大学健康科学中心提供的25,000美元 (UTHSC)，25,000美元来自德克萨斯大学M.D.安德森癌症中心(MDACC)，115,000美元来自 贝勒医学院(BCM)。所有P/F申请获得批准的调查人员都有 优先使用我们的核心，为期1年，或在授予期间。从2013年到2016年，我们收到 每轮奖项的申请人数为17-26人。将于2017年提供资金，对于这一竞争性续签申请， 我们收到41份意向书和22份填妥的复核申请。排名前4位的建议包括在 这一竞争性续订申请说明了我们DDC能够进行的新GI研究的广度和质量 刺激和促进。爱国阵线方案有一名主任和两名助理主任，代表三名 各机构(BCM、UTHSC、MDACC)和一个科学审查委员会。我们有几个正式的流程 用于征求和审查政协提案。审查、排名和资助基金会提案的考虑因素包括 项目的新颖性、可行性、申请者的资历和生产率、与DDC主题的关系、 项目将带来新知识和获得外部资金的可能性，以及使用我们的DDC的可能性 核心。我们的P/F计划、儿科和成人GI培训计划，包括职业发展倡议 向所有DDC成员开放，帮助招聘新教师，并促进 初级和高级DDC调查员。

Project Summary One of the most important programs of our Texas Medical Center Digestive Diseases Center (called DDC) is the Pilot and Feasibility (P/F) Program. The goals of the P/F Program are to provide developmental funds to support (1) young investigators starting a career in gastrointestinal (GI) research, or (2) to foster the development of GI- related research by both junior faculty and established investigators in non-GI related fields in the Texas Medical Center. This is accomplished by supporting investigator-initiated scientific studies to develop preliminary data for new research projects. Novel approaches to studying GI-related areas complementing the scope of our Center are encouraged. Awards are made following a rigorous peer-review system that involves an initial evaluation for scientific merit by a Scientific Review Committee, including the DDC Internal Advisory Committee members and ad hoc scientists in the Texas Medical Center, and the External Advisors of our DDC. This core has a strong record of accomplishments. In the past 10 years, we have supported 68 P/F recipients, of whom 41 have gone on to receive $40,172,685 in external direct cost funding representing a 60% success rate and yielding a 23-fold return on investment (ROI) of DDC funds. We are requesting $100,000/year in years 16-20 to continue this PF program. This funding will be significantly enhanced each year by additional commitments from our three supporting Institutions, including $25,000 from The University of Texas Health Science Center (UTHSC), $25,000 from The University of Texas M.D. Anderson Cancer Center (MDACC) and $115,000 from Baylor College of Medicine (BCM). All investigators whose P/F Applications are approved for funding have priority access to our Cores for 1 year, or for the duration of their award. From 2013-2016, we received between 17-26 applications for each round of awards. To be funded in 2017, and for this competitive renewal application, we received 41 letters of intent and 22 completed applications for review. The top 4 proposals are included in this competitive renewal application to illustrate the breadth and quality of the new GI research our DDC is able to stimulate and facilitate. The PF program has a Director and two Assistant Directors, representing the three institutions (BCM, UTHSC, MDACC), and a Scientific Review Committee. We have several formal processes for soliciting and reviewing PF Proposals. Considerations for review, ranking and funding of PF proposals include project novelty, feasibility, qualifications and productivity of applicants, relationship to our DDC theme, the likelihood that the project will lead to new knowledge and the acquisition of external funding, and use of our DDC cores. Our P/F Program, pediatric and adult-GI training programs that include career-development initiatives open to all DDC members help recruit new faculty and foster collaborative, multidisciplinary interactions among junior and senior DDC investigators.