Pilot Feasibility Program

试点可行性方案项目总结 我们德克萨斯医疗中心消化疾病中心(DDC)最重要的项目之一是试点 和可行性(P/F)计划。P/F计划的目标是提供试点资金，以(1)支持青年 研究人员开始从事消化疾病(DD)研究和(2)促进与消化疾病相关的发展 由德克萨斯医学中心非DD相关领域的初级和资深研究人员进行的研究。这些 目标的实现是通过支持研究人员发起的科学研究来为新的 研究项目。研究DD相关主题的新方法补充了DDC的目标 很受鼓舞。奖项的颁发经过了严格的同行评审程序，其中包括对 科学审查委员会的科学价值，该委员会包括DDC内部咨询委员会成员， 来自德克萨斯医学中心的临时科学家和DDC外部咨询委员会成员。 我们要求每年100,000美元以继续P/F计划。这笔资金通过以下方式显著增加 来自我们的三个伙伴机构的额外年度承诺，包括来自加州大学的25,000美元 德克萨斯健康科学中心(UTHSC)，德克萨斯大学M.D.安德森癌症中心提供2.5万美元 (MDACC)和贝勒医学院(BCM)115,000美元。所有P/F获奖者都有权优先访问我们的 核心期为1年或在获奖期间。 P/F计划有很强的成就记录。在过去的10年里，我们已经支持了71个P/F 获奖者，其中36人共获得49,313,693美元的外部直接费用资助， 代表DDC基金51%的成功率和24倍的投资回报。 从2018年到2022年，我们每年收到11到27份申请(平均19份)。对于2022年的资金，我们 收到20份意向书，11份申请已完成审查。介绍了排名前四位的建议 在这一申请中，以说明由DDC刺激和促进的新研究的广度和质量。 P/F方案有一名主任和两名助理主任，代表三个伙伴机构(BCM， UTHSC、MDACC)和科学审查委员会。我们有几个正式的征集和 审查P/F建议书。评审考虑因素包括项目的新颖性、可行性、资质、申请者 生产力，并与我们的DDC主题保持一致，该项目将带来新知识和 外部资金，以及我们DDC核心的使用。我们的P/F计划与我们的儿科和成人-DD培训相结合 向所有DDC成员开放职业发展计划的计划有助于招聘新教师和培养 所有DDC成员之间的协作、多学科互动。

PILOT FEASIBILITY PROGRAM PROJECT SUMMARY One of the most important programs of our Texas Medical Center Digestive Diseases Center (DDC) is the Pilot and Feasibility (P/F) Program. The goals of the P/F Program are to provide pilot funds to (1) support young investigators starting a career in digestive disease (DD) research and (2) foster the development of DD-related research by both junior and established investigators in non-DD related fields in the Texas Medical Center. These goals are accomplished by supporting investigator-initiated scientific studies to generate preliminary data for new research projects. Novel approaches for studying DD-related topics that complement the DDC’s goals are encouraged. Awards are granted following a rigorous peer-review process that involves an evaluation for scientific merit by a Scientific Review Committee, which includes DDC Internal Advisory Committee members, ad hoc scientists from the Texas Medical Center, and DDC External Advisory Committee members. We are requesting $100,000/year to continue the P/F Program. This funding is significantly enhanced by additional annual commitments from our three partner institutions, including $25,000 from The University of Texas Health Science Center (UTHSC), $25,000 from The University of Texas M.D. Anderson Cancer Center (MDACC) and $115,000 from Baylor College of Medicine (BCM). All P/F awardees have priority access to our Cores for 1 year or for the duration of their award. The P/F Program has a strong record of accomplishments. In the past 10 years, we have supported 71 P/F recipients, 36 of whom have collectively been awarded $49,313,693 in extramural direct cost funding, representing a 51% success rate and a 24-fold return on investment of DDC funds. From 2018 to 2022, we received between 11 and 27 applications per year (average 19). For 2022 funding, we received 20 letters of intent, and 11 applications were completed for review. The top four proposals are described in this application to illustrate the breadth and quality of the new research stimulated and facilitated by the DDC. The P/F program has a Director and two Assistant Directors, representing the three partner institutions (BCM, UTHSC, MDACC), and a Scientific Review Committee. We have several formal processes for soliciting and reviewing P/F proposals. Review considerations include project novelty, feasibility, qualifications, applicant productivity, and alignment to our DDC theme, the likelihood the project will lead to new knowledge and extramural funding, and use of our DDC Cores. Our P/F Program coupled with our pediatric and adult-DD training programs with career-development initiatives open to all DDC members help recruit new faculty and foster collaborative, multidisciplinary interactions among all DDC members.