Training Program in Translational Science, HIV, and Sexual and Gender Minority Health

转化科学、艾滋病毒、性和性别少数群体健康培训计划

• 批准号: 10608209
• 负责人: Michael E Newcomb
• 金额: $ 51.93万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608209
• 关键词: HIV; Sexual and Gender Minorities; Training Programs; Translational Research; gender minority health

Project Summary Sexual and gender minorities (SGM) are heavily burdened by HIV in the U.S., including cisgender sexual minority men, transgender women and men, and non-binary people assigned male at birth. SGM also experience vast health inequities outside of HIV, including mental health problems, substance use, and various physical health outcomes. Minority stressors (i.e., those unique to SGM) are linked to HIV-related outcomes and mental health, driven by various biopsychosocial processes. Further, these health issues do not occur in a vacuum; multiple, comorbid health-related issues interact synergistically to form a “syndemic” that drives HIV incidence and HIV care outcomes among SGM. In order to rapidly address these issues, we need skilled translational scientists who can delineate the mechanistic processes driving disparities, translate findings into interventions, and implement programs with communities. Built on the infrastructure of Northwestern's Institute for Sexual and Gender Minority Health and Wellbeing, the TrainingProgram in Translational Science, HIV, andSexual and Gender Minority Health (NU-THRIVE)will support promising scientists in building the skills necessary to understand these complex relationships and mitigate health disparities impacting SGM people, including HIV. NU-THRIVE aims to train postdoctoral fellows in research methods across the Translational Science Spectrum through a rigorous program in which they will: 1) specialize and gain depth of knowledge in 2 Translational Science Skill Domains (i.e., Quantitative Methods, Qualitative Methods, Interventions & Trials, Implementation Science) through mentored research; and 2) gain breadth of knowledge in all 4 domains through a formal training curriculum. NU-THRIVE will support 3 new postdoctoral fellows per year, on 2-year appointments. We expect a majority will have a PhD (behavioral/social science) and a minority will be MD physician-scientists. Fellows will select 1 Primary and 1 Secondary Mentor. Primary Mentors are faculty who focus primarily on HIV, mental health, and/or SGM health. Secondary Mentors come from a range of disciplines and have expertise complementary to the aims of NU-THRIVE but may work outside of or adjacent to HIV and mental health among SGM. Fellows will gain knowledge and skills in 8 core competencies: 1) translational science in HIV & SGM health; 2) biopsychosocial drivers of HIV, mental health, & associated comorbidities; 3) developmental lifespan & environmental influences on HIV, mental health, & comorbidities; 4) intersectional identities, HIV, & SGM health; 5) team science skills; 6) ethics & responsible conduct of research; 7) writing, dissemination, & grantsmanship; 8) professional & career development. NU-THRIVE training modalities will include mentored research activities, a didactic seminar series, intensive trainings in translational science methods, structured writing support, and other activities available in the rich Northwestern environment. NU-THRIVE will place fellows at the forefront of HIV and SGM health research, with the goal of more rapidly moving basic science discoveries to efficacious interventions and onward toward implementation.

项目摘要 在美国，性和性别少数群体（SGM）受到艾滋病毒的严重影响，包括顺性别性行为 少数民族男性、变性女性和男性以及出生时被指定为男性的非二元人群。SGM还 在艾滋病毒之外，我们经历了巨大的健康不平等，包括心理健康问题，物质使用，以及各种 身体健康结果。少数压力源（即，与艾滋病毒相关的结果有关 和心理健康，由各种生物心理社会过程驱动。此外，这些健康问题不会发生在 真空;多种共病的健康相关问题协同作用，形成驱动艾滋病毒的“综合流行病” 艾滋病毒感染率和艾滋病毒护理结果。为了迅速解决这些问题，我们需要熟练的 翻译科学家谁可以描绘驱动差异的机械过程，将发现转化为 干预措施，并与社区一起实施方案。建立在西北大学研究所的基础设施上 性和性别少数群体健康和福祉，转化科学培训计划，艾滋病毒， 性和性别少数群体健康（NU-THRIVE）将支持有前途的科学家建立技能， 了解这些复杂的关系并减轻影响SGM人群的健康差异是必要的， 包括艾滋病毒。NU-THRIVE旨在培养博士后研究人员在整个翻译方法 科学光谱通过一个严格的计划，他们将：1）专业化，并获得知识的深度， 2翻译科学技能领域（即，定量方法，定性方法，干预和试验， 实施科学）通过指导研究;和2）获得所有4个领域的知识广度 通过正式的培训课程。NU-THRIVE将每年支持3名新的博士后研究员，为期两年 约会.我们预计大多数人将拥有博士学位（行为/社会科学），少数人将是MD 物理科学家研究员将选择1名主要和1名次要导师。初级导师是指 主要关注艾滋病毒、心理健康和/或SGM健康。中学导师来自一系列 学科和专业知识的补充NU-THRIVE的目标，但可能会工作以外或邻近 艾滋病和心理健康的影响。研究员将获得8个核心能力的知识和技能：1） 艾滋病毒和SGM健康的转化科学; 2）艾滋病毒，心理健康和相关的生物心理社会驱动因素 共病; 3）发育寿命和环境对艾滋病毒、心理健康和共病的影响; 4） 交叉身份，艾滋病毒和SGM健康; 5）团队科学技能; 6）道德和负责任的行为 研究; 7）写作，传播，和granitarian; 8）专业和职业发展。NU-THRIVE 培训方式将包括指导研究活动、教学研讨会系列、 翻译科学方法，结构化的写作支持，以及其他活动，可在丰富的西北 环境NU-THRIVE将把研究员放在艾滋病毒和SGM健康研究的最前沿，目标是 更快地将基础科学发现转化为有效的干预措施并付诸实施。