权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Alcohol and Addiction Research Domain Criteria and Alcohol Use Disorder Recovery

酒精和成瘾研究领域标准和酒精使用障碍康复

基本信息

批准号：
10380588
负责人：
Katie A Witkiewitz
金额：
$ 34.07万
依托单位：
UNIVERSITY OF NEW MEXICO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-05 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380588
关键词：
Abstinence Address Aftercare Age Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Behavior Behavioral Biological Client Clinical Clinical Trials Clinical assessments Consumption Data Data Analyses Decision Making Development Emotional Environmental Risk Factor Ethnic Origin Evidence based treatment Funding Future Goals Heavy Drinking Heterogeneity Impairment Impulsivity Individual Investments Longterm Follow-up Measurement Methodology Modeling National Institute on Alcohol Abuse and Alcoholism Nature Neuronal Dysfunction Outcome Outpatients Pain Pattern Phenotype Policy Maker Precision Medicine Initiative Predictive Factor Probability Provider Public Health Race Recovery Recovery of Function Relapse Research Research Domain Criteria Rewards Risk Sampling Self Efficacy Social support Strategic Planning Subgroup Sum System Testing Treatment outcome Typology United Kingdom Work addiction alcohol abstinence alcohol abuse therapy alcohol relapse alcohol related problem alcohol use disorder base biopsychosocial clinical decision-making clinical practice coping cost data integration drinking emotional functioning executive function functional outcomes improved incentive salience knowledge base novel precision medicine programs psychologic sex treatment planning treatment trial

项目摘要

Project Summary/Abstract The alcohol and addiction research domain criteria (AARDoC) has been proposed to provide a framework for understanding the nature of alcohol use disorder (AUD) in terms of psychological and biological constructs that can be traced to a specific behavioral function with an underlying biological basis (e.g., neural dysfunction). The AARDoC proposes that AUD develops, progresses, and is maintained because of heightened incentive salience for alcohol, greater negative emotionality, and/or impairments in executive functioning and impulsivity. AARDoC was proposed in 2015 with the goal of improving efforts at precision medicine for AUD. As such, it is critically important that clinical assessments based on the AARDoC framework be studied and validated in order to inform clinical decision making and precision medicine initiatives for AUD. The AARDoC may also have utility in predicting AUD treatment outcomes and AUD recovery. There is an accumulation of evidence that drinking reductions are both achievable and associated with improvements in functioning among individuals with AUD. Examining whether drinking reductions can be associated with meaningful recovery of functioning is critically important because many individuals do not seek treatment because they do not want to abstain from alcohol, yet treatment systems are mostly focused on abstinence as a necessary and sufficient condition for recovery. Expanding the definition of recovery to include non-abstinent recoveries and other functional outcomes could increase acceptability of non-abstinent treatment goals among providers, increase treatment seeking among those with AUD who are not willing to abstain completely, and ultimately reduce the public health burden of untreated AUD. To address these gaps in understanding, this study will build an empirical knowledge base regarding clinical assessments that could be used to identify the AARDoC constructs and will examine whether the AARDoC constructs are associated with a novel typology of alcohol recovery, defined by consumption and functioning, among individuals who receive alcohol treatment. To achieve the study aims, integrative data analysis of AARDoC constructs among more than 3600 individuals (n = 3,672) who participated in three publicly funded alcohol treatment studies will be examined. This research will examine a broad definition of recovery and prediction of AUD recovery up to 10 years following an AUD treatment episode. The results from this study will be directly applicable to clinical practice and future research on AUD precision medicine. Project Relevance This study seeks to gain a better understanding of variability among individuals with alcohol use disorder who are seeking treatment and predictors of recovery from alcohol use disorder. The results will build a scientific knowledge base that will help guide future precision medicine initiatives, alcohol treatment planning, and decision-making among clients, clinicians, program evaluators, and policy makers, which may ultimately improve clinical outcomes and decrease the public health burden of alcohol use disorder.

项目总结/摘要酒精和成瘾研究领域标准（AARDoC）旨在为以下方面提供一个框架：了解酒精使用障碍（AUD）的心理和生物结构，可以追溯到具有潜在生物学基础的特定行为功能（例如，神经功能障碍）。 AARDoC提出AUD的发展、进步和维持是因为激励的提高酒精的突出性，更大的负面情绪，和/或执行功能和冲动的障碍。 AARDoC于2015年提出，旨在改善AUD的精准医学工作。因此，它是至关重要的是，基于AARDoC框架的临床评估应在以下方面进行研究和验证：以便为AUD的临床决策和精准医疗计划提供信息。AARDoC还可以可用于预测AUD治疗结局和AUD恢复。有大量证据表明减少饮酒是可以实现的，并且与改善功能有关。个人AUD研究饮酒减少是否与有意义的恢复有关，功能是至关重要的，因为许多人不寻求治疗，因为他们不想戒酒，但治疗系统大多集中在戒酒作为一个必要的和充分的恢复的条件。扩大康复的定义，以包括非禁欲康复和其他功能性结果可以提高提供者对非禁欲治疗目标的接受程度，在不愿意完全戒除的AUD患者中寻求治疗，并最终减少未经治疗的AUD的公共卫生负担。为了解决这些理解上的差距，本研究将建立一个关于可用于识别AARDoC的临床评估的经验知识库并将研究AARDoC结构是否与一种新的酒精类型有关恢复，由消费和功能定义，在接受酒精治疗的个人中。到为了达到研究目的，对3600多名个体（n）的AARDoC结构进行了综合数据分析， = 3，672）参加了三项公共资助的酒精治疗研究。本研究将研究恢复的广泛定义以及澳元兑美元汇率下跌后10年内澳元恢复的预测。治疗插曲。本研究的结果将直接应用于临床实践和未来的研究关于AUD精准医疗项目相关性这项研究旨在更好地了解酒精使用障碍患者的变异性，正在寻求酒精使用障碍的治疗和康复预测。研究结果将建立科学的知识库，将有助于指导未来的精准医疗计划，酒精治疗计划，客户、临床医生、项目评估者和政策制定者之间的决策，最终可能改善临床结果，减少酒精使用障碍的公共卫生负担。