NICHD maternal fetal medicine units network

摘要 本提案描述了俄亥俄州州立大学（OSU）中心继续参与的申请 Eunice Kennedy Shriver NICHD产妇胎儿医学单位（MFMU）网络。当前应用程序 描述了我们的团队、环境和资源，以实现网络的目标。自1992年以来，OSU 中心在开展临床和翻译方面表现出强大的性能和经验 研究基于良好的基础设施和机构支持。我们建立了一个强大的研究团队， 由Maged Costantine博士于2019年被招募到OSU Wexner医疗中心，作为一个部门 产妇胎儿医学主任和MFMU网络中心的首席研究员，马克 Landon，MD，他担任OG/GYN部门的主席和候补PI。除了生产力， MFMU网络，包括PI和替代PI，在研究设计，招募，数据 分析和出版物。OSU网络将在3岁时从不同人群中招募研究参与者 医疗中心每年总共有超过15,000名新生儿，其中许多是高风险的， 大多数人在三个系统接受产前护理。我们的中心护士协调员，安娜巴塞洛缪， MPH，RN，BSN，CCRP，领导着一大批能够招聘和留住教师和研究人员的团队 患者在一个优秀的研究机构的设置增强了29年的经验，在MFMU 网络，参与NICHD无产网络，并成为北美胎儿组织的成员 治疗网络和俄亥俄州围产期研究网络（OPRN）。我们受益于强大的生物信息学 结构化和多功能的电子医疗记录系统（EMR），可记录产前、产时和 产后数据在线，并随时可供授权的研究人员查询，以及自动 通知，一个非凡的产科超声医师，围产期流行病学家，和一个成熟的 研究基础设施由CTSA赠款与全国儿童医院共享支持。我们的卫星 位于代顿的迈阿密山谷医院和位于辛辛那提的好撒玛利亚医院都有出色的记录 在最近的网络周期，良好的研究文化和雄心勃勃的目标，招聘 MFMU网络参与。我们的伙伴关系和强大的合作与新生儿在全国范围内 儿童医院在临床护理和研究、病理学和临床检验等方面为我们增添了实力 应用程序.我们期待着继续我们的服务传统，强大的性能和创新， NICHD MFMU网络的下一个周期。我们接受RFA的人头和参与规定， 随时准备以合作方式完成正在进行的研究，以实现网络的目标 所有研究中心。

ABSTRACT This proposal describes the application of The Ohio State University (OSU) Center for continued participation in the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The current application describes our team, environment and resources to meet the objectives of the Network. Since 1992, the OSU Center has demonstrated a strong performance and experience in conducting clinical and translational research based on excellent infrastructure and institutional support. We developed a strong research team led by Maged Costantine, MD who was recruited to the OSU Wexner Medical Center in 2019, as a Division Director for Maternal Fetal Medicine and Principal Investigator for the MFMU Network Center, and Mark Landon, MD who serves as Chair for the Department of OG/GYN and Alternate PI. In addition to productivity in the MFMU Network, both the PI and alternate PI, bring extensive experience in study design, recruitment, data analysis, and publications. The OSU Network will recruit study participants from diverse populations at 3 medical centers with a combined total of more than 15,000 annual births, many of them are high-risk, and the majority receiving prenatal care at the three systems. Our Center Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of faculty & research staff capable of recruiting and retaining patients in the setting of an excellent research organization enhanced by 29 years of experience in the MFMU Network, participation in the NICHD Nulliparous Network, and memberships in the North American Fetal Treatment Network, and Ohio Perinatal Research Network (OPRN). We benefit from a robust bioinformatics structure and versatile Electronic Medical Record System (EMR) that captures antepartum, intrapartum, and postpartum data online and is readily available to authorized research personnel for query as well as automatic notification, an extraordinary group of obstetrical sonographers, perinatal epidemiologists, and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite sites, Miami Valley Hospital in Dayton and Good Samaritan Hospital in Cincinnati, have an outstanding record of recruitment in the most recent Network cycle, well-established research culture, and ambitious goals for MFMU Network participation. Our partnership and strong collaboration with Neonatology at Nationwide Children’s Hospital in clinical care and research, Pathology and Clinical Laboratory add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the next cycle of the NICHD MFMU Network. We accept the RFA’s capitation and participatory stipulations and stand ready to achieve the goals of the Network in completion of the ongoing studies in a collaborative way across all research centers.