NICHD maternal fetal medicine units network

NICHD母胎医学单位网

• 批准号: 10681772
• 负责人: Maged Costantine
• 金额: $ 34.64万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-08 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681772
• 关键词: Adherence; American; Anesthesiology; Authorization documentation; Beds; Bioinformatics; Birth; Caring; Cesarean section; Child; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Collaborations; Collection; Conduct Clinical Trials; Data; Data Analyses; Data Collection; Data Coordinating Center; Dedications; Department chair; Discipline of obstetrics; Disparity; Eligibility Determination; Ensure; Environment; Epidemiologist; Epidemiology; Equity; Faculty; Foundations; Goals; Grant; Health system; Helping to End Addiction Long-term; Hepatitis C; Hospitals; Human Resources; Induced Labor; Information Dissemination; Infrastructure; Inpatients; Institution; Knowledge; Laboratories; Lactation; Link; Longterm Follow-up; Manuscripts; Maternal Mortality; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Multi-Institutional Clinical Trial; Multi-site clinical study; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatology; Network-based; Notification; Nurses; Observational Study; Obstetric pharmacology; Ohio; Outcome; Outpatients; Participant; Pathology; Patient Recruitments; Patients; Pediatric Hospitals; Performance; Perinatal; Perinatal mortality demographics; Persons; Pharmacology; Population Heterogeneity; Positioning Attribute; Postpartum Period; Pre-Eclampsia; Pregnancy in Diabetics; Premature Birth; Prenatal care; Prevention; Procedures; Process; Productivity; Protocols documentation; Provider; Publishing; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Subjects; Researching COVID to Enhance Recovery; Resources; Services; Site; Structure; Study Subject; System; Therapeutic; Translational Research; Trial of Labor; United States National Institutes of Health; Universities; acute care; antenatal; authority; clinical center; clinical infrastructure; clinical investigation; collaborative approach; collaborative environment; data access; data quality; data sharing; disparity reduction; electronic medical record system; ethnic disparity; ethnic diversity; experience; fetal; follow-up; high risk; high risk population; improved; infant morbidity/mortality; innovation; intrapartum; maternal morbidity; member; novel; obstetric care; obstetric outcomes; opioid use disorder; organizational structure; patient oriented; patient retention; perinatal health; perinatal morbidity; pregnancy health; pregnant; prevent; programs; protocol development; racial disparity; racial diversity; recruit; response; retention rate; study population

ABSTRACT This proposal describes the team, environment, and resources of The Ohio State University (OSU) Center that allow it to substantively and meaningfully participate in, and meet the objectives of, the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The OSU Center has demonstrated strong performance and experience in conducting clinical and translational research due to its scientific expertise, excellent infrastructure, and institutional support. The research team for this proposal is led by Maged Costantine, MD, who serves as Division Director for Maternal-Fetal Medicine and PI for the MFMU Network Center, and William Grobman, MD, MBA, who serves as Vice-Chair for the Department of OB/GYN and Alternate PI for the MFMU Network Center. In addition to their productivity within the MFMU Network, both the PI and Alternate PI bring extensive experience in study design, recruitment, data analysis, and dissemination of results. Their research foci on disparities in obstetric care and outcomes, perinatal pharmacology, epidemiology, clinical trial design, and translational research is complementary and will be an asset to the Network. The OSU Center will recruit study participants from racially and ethnically diverse populations at 2 medical centers with a combined total of more than 10,000 annual births, many of which are to high-risk individuals who receive prenatal care within the two systems. Our Center’s Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of research staff capable of recruiting and retaining patients in the setting of a research organization that has 32 of years of experience in the MFMU Network; demonstrable experience in multiple other cooperative research settings, including the NICHD nuMoM2b Network, NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT), NIH Helping to End Addiction Long-term (HEAL), and the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative; and engagement with other multi-site initiatives such as the North American Fetal Treatment Network, Ohio Better Birth Outcomes, and Ohio Perinatal Research Network. We additionally benefit from a robust bioinformatics structure and versatile Electronic Medical Record System that captures antepartum, intrapartum, and postpartum data and is readily available to authorized research personnel for data query and notification of research subjects’ eligibility; an extraordinary group of obstetrical sonographers and perinatal epidemiologists; and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite site, Miami Valley Hospital in Dayton, has an outstanding record of recruitment in the prior Network cycles, well-established research culture, and ambitious goals for MFMU Network participation. Our strong clinical and research collaboration with OSU neonatology [including in the Neonatal Research Network (NRN)], anesthesiology, pathology, the clinical laboratory, and pharmacology add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the renewed NICHD MFMU Network, and accept the RFA’s capitation and participatory stipulations.

抽象的 该建议描述了俄亥俄州立大学（OSU）中心的团队，环境和资源 允许其实质而有意义地参与并实现Eunice Kennedy Shriver的目标 NICHD孕妇医学单位（MFMU）网络。 OSU中心表现出强劲的性能 以及由于其科学专业知识而进行临床和翻译研究的经验 基础设施和机构支持。该提案的研究团队由医学博士Maged Costantine领导 他担任MFMU网络中心的母亲 - 福利医学和PI的部门主管，威廉 医学博士Grobman，MBA，担任OB/GYN部的副主席，并担任MFMU的替代PI 网络中心。除了它们在MFMU网络中的生产力外，PI和替代Pi都带来 在研究设计，招聘，数据分析和结果传播方面的丰富经验。他们的研究 重点介绍产科护理和结果的差异，围产期药理学，流行病学，临床试验设计， 翻译研究是完整的，将成为网络的资产。 OSU中心将招募 来自2个医疗中心的大约和种族多样性人群的研究参与者，总计合计 超过10,000个年龄，其中许多是在接受产前护理的高风险个人 两个系统。我们中心的护士协调员Anna Bartholomew，MPH，RN，BSN，CCRP领导着一群人 在有32个研究组织的情况下，能够招募和保留患者的研究人员 在MFMU网络中的多年经验；在其他多项合作研究中可证明的经验 设置，包括NICHD NUMOM2B网络，NICHD母体和儿科精度 （mprint），NIH有助于长期结束成瘾（治愈），并研究COVID 恢复（恢复）倡议；并与其他多站点倡议（例如北美）互动 胎儿治疗网络，俄亥俄州更好的出生结果和俄亥俄州围产期研究网络。我们另外 受益于强大的生物信息学结构和多功能电子病历系统，该系统捕获 产前，肠内和产后数据，授权的研究人员很容易获得数据 查询和通知研究对象的资格；一群非凡的产科超声师和 围产期流行病学家；以及由CTSA赠款与与之共享的成熟研究基础设施 全国儿童医院。我们位于代顿的卫星网站，迈阿密谷医院，有着杰出的记录 在先前的网络周期，公认的研究文化和MFMU雄心勃勃的目标中招募 网络参与。我们与OSU Neonatology的强大临床和研究合作[包括 新生儿研究网络（NRN）]，麻醉学，病理学，临床实验室和药理学补充 我们应用的优势。我们期待继续我们的服务传统，强大的绩效和 在新的NICHD MFMU网络中进行创新，并接受RFA的资本化和参与规定。