NICHD maternal fetal medicine units network

摘要 本建议书描述了俄亥俄州立大学(OSU)中心的团队、环境和资源 允许它实质性和有意义地参与和实现尤尼斯·肯尼迪·施莱弗的目标 NICHD母胎医学单位(MFMU)网络俄亥俄州立大学中心表现强劲 和进行临床和翻译研究的经验，由于其科学专业知识，出色 基础设施和制度支持。该提案的研究团队由医学博士马吉德·科斯坦丁领导， 世卫组织担任MFMU网络中心母婴医学部主任和PI，威廉 Grobman，医学博士，MBA，担任OB/GYN部门副主席和MFMU候补PI 网络中心。除了他们在MFMU网络中的生产力之外，PI和备用PI都带来了 在研究设计、招聘、数据分析和结果传播方面有丰富的经验。他们的研究 重点关注产科护理和结局、围产期药理学、流行病学、临床试验设计、 翻译研究是相辅相成的，将是网络的一项资产。俄亥俄州立大学中心将招聘 这项研究的参与者来自两个医疗中心的种族和民族多样化的人群，总共有 每年超过10,000名新生儿，其中许多是高危个体，他们在 两个系统。我们中心的护士协调员Anna Bartholomew，公共卫生部长，RN，BSN，CCRP领导一个大小组 在一个拥有32名研究人员的研究机构中，有能力招募和留住患者的研究人员的比例 在MFMU网络中的多年经验；在多个其他合作研究中的明显经验 环境，包括NICHD nuMoM2B网络、NICHD产妇和儿科治疗精确度 (MPRINT)，NIH帮助结束长期成瘾(Hear)，以及NIH研究COVID以增强 恢复(恢复)倡议；参与其他多地点倡议，如北美 俄亥俄州胎儿治疗网络、更好的分娩结局和俄亥俄州围产期研究网络。此外，我们还 得益于强大的生物信息学结构和多功能电子病历系统，该系统可捕获 产前、产中和产后数据，授权研究人员可以随时获得数据 查询和通知研究对象的资格；一群非凡的产科超声医师和 围产期流行病学家；成熟的研究基础设施，由CTSA与 全国儿童医院。我们的卫星站点，代顿的迈阿密山谷医院，有着出色的记录 在之前的网络周期中的招聘，良好的研究文化，以及MFMU的雄心勃勃的目标 网络参与。我们与俄亥俄州立大学新生儿科的强大临床和研究合作[包括在 新生儿研究网络(NRN)]、麻醉学、病理学、临床实验室和药理学 增强了我们的应用程序的优势。我们期待着继续我们的服务传统，强劲的表现，以及 在更新的NICHD MFMU网络中进行创新，并接受RFA的强制和参与性规定。

ABSTRACT This proposal describes the team, environment, and resources of The Ohio State University (OSU) Center that allow it to substantively and meaningfully participate in, and meet the objectives of, the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The OSU Center has demonstrated strong performance and experience in conducting clinical and translational research due to its scientific expertise, excellent infrastructure, and institutional support. The research team for this proposal is led by Maged Costantine, MD, who serves as Division Director for Maternal-Fetal Medicine and PI for the MFMU Network Center, and William Grobman, MD, MBA, who serves as Vice-Chair for the Department of OB/GYN and Alternate PI for the MFMU Network Center. In addition to their productivity within the MFMU Network, both the PI and Alternate PI bring extensive experience in study design, recruitment, data analysis, and dissemination of results. Their research foci on disparities in obstetric care and outcomes, perinatal pharmacology, epidemiology, clinical trial design, and translational research is complementary and will be an asset to the Network. The OSU Center will recruit study participants from racially and ethnically diverse populations at 2 medical centers with a combined total of more than 10,000 annual births, many of which are to high-risk individuals who receive prenatal care within the two systems. Our Center’s Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of research staff capable of recruiting and retaining patients in the setting of a research organization that has 32 of years of experience in the MFMU Network; demonstrable experience in multiple other cooperative research settings, including the NICHD nuMoM2b Network, NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT), NIH Helping to End Addiction Long-term (HEAL), and the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative; and engagement with other multi-site initiatives such as the North American Fetal Treatment Network, Ohio Better Birth Outcomes, and Ohio Perinatal Research Network. We additionally benefit from a robust bioinformatics structure and versatile Electronic Medical Record System that captures antepartum, intrapartum, and postpartum data and is readily available to authorized research personnel for data query and notification of research subjects’ eligibility; an extraordinary group of obstetrical sonographers and perinatal epidemiologists; and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite site, Miami Valley Hospital in Dayton, has an outstanding record of recruitment in the prior Network cycles, well-established research culture, and ambitious goals for MFMU Network participation. Our strong clinical and research collaboration with OSU neonatology [including in the Neonatal Research Network (NRN)], anesthesiology, pathology, the clinical laboratory, and pharmacology add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the renewed NICHD MFMU Network, and accept the RFA’s capitation and participatory stipulations.