NICHD maternal fetal medicine units network

NICHD母胎医学单位网

• 批准号: 10681772
• 负责人: Maged Costantine
• 金额: $ 34.64万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-08 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681772
• 关键词: Adherence; American; Anesthesiology; Authorization documentation; Beds; Bioinformatics; Birth; Caring; Cesarean section; Child; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Collaborations; Collection; Conduct Clinical Trials; Data; Data Analyses; Data Collection; Data Coordinating Center; Dedications; Department chair; Discipline of obstetrics; Disparity; Eligibility Determination; Ensure; Environment; Epidemiologist; Epidemiology; Equity; Faculty; Foundations; Goals; Grant; Health system; Helping to End Addiction Long-term; Hepatitis C; Hospitals; Human Resources; Induced Labor; Information Dissemination; Infrastructure; Inpatients; Institution; Knowledge; Laboratories; Lactation; Link; Longterm Follow-up; Manuscripts; Maternal Mortality; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Multi-Institutional Clinical Trial; Multi-site clinical study; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatology; Network-based; Notification; Nurses; Observational Study; Obstetric pharmacology; Ohio; Outcome; Outpatients; Participant; Pathology; Patient Recruitments; Patients; Pediatric Hospitals; Performance; Perinatal; Perinatal mortality demographics; Persons; Pharmacology; Population Heterogeneity; Positioning Attribute; Postpartum Period; Pre-Eclampsia; Pregnancy in Diabetics; Premature Birth; Prenatal care; Prevention; Procedures; Process; Productivity; Protocols documentation; Provider; Publishing; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Subjects; Researching COVID to Enhance Recovery; Resources; Services; Site; Structure; Study Subject; System; Therapeutic; Translational Research; Trial of Labor; United States National Institutes of Health; Universities; acute care; antenatal; authority; clinical center; clinical infrastructure; clinical investigation; collaborative approach; collaborative environment; data access; data quality; data sharing; disparity reduction; electronic medical record system; ethnic disparity; ethnic diversity; experience; fetal; follow-up; high risk; high risk population; improved; infant morbidity/mortality; innovation; intrapartum; maternal morbidity; member; novel; obstetric care; obstetric outcomes; opioid use disorder; organizational structure; patient oriented; patient retention; perinatal health; perinatal morbidity; pregnancy health; pregnant; prevent; programs; protocol development; racial disparity; racial diversity; recruit; response; retention rate; study population

ABSTRACT This proposal describes the team, environment, and resources of The Ohio State University (OSU) Center that allow it to substantively and meaningfully participate in, and meet the objectives of, the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The OSU Center has demonstrated strong performance and experience in conducting clinical and translational research due to its scientific expertise, excellent infrastructure, and institutional support. The research team for this proposal is led by Maged Costantine, MD, who serves as Division Director for Maternal-Fetal Medicine and PI for the MFMU Network Center, and William Grobman, MD, MBA, who serves as Vice-Chair for the Department of OB/GYN and Alternate PI for the MFMU Network Center. In addition to their productivity within the MFMU Network, both the PI and Alternate PI bring extensive experience in study design, recruitment, data analysis, and dissemination of results. Their research foci on disparities in obstetric care and outcomes, perinatal pharmacology, epidemiology, clinical trial design, and translational research is complementary and will be an asset to the Network. The OSU Center will recruit study participants from racially and ethnically diverse populations at 2 medical centers with a combined total of more than 10,000 annual births, many of which are to high-risk individuals who receive prenatal care within the two systems. Our Center’s Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of research staff capable of recruiting and retaining patients in the setting of a research organization that has 32 of years of experience in the MFMU Network; demonstrable experience in multiple other cooperative research settings, including the NICHD nuMoM2b Network, NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT), NIH Helping to End Addiction Long-term (HEAL), and the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative; and engagement with other multi-site initiatives such as the North American Fetal Treatment Network, Ohio Better Birth Outcomes, and Ohio Perinatal Research Network. We additionally benefit from a robust bioinformatics structure and versatile Electronic Medical Record System that captures antepartum, intrapartum, and postpartum data and is readily available to authorized research personnel for data query and notification of research subjects’ eligibility; an extraordinary group of obstetrical sonographers and perinatal epidemiologists; and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite site, Miami Valley Hospital in Dayton, has an outstanding record of recruitment in the prior Network cycles, well-established research culture, and ambitious goals for MFMU Network participation. Our strong clinical and research collaboration with OSU neonatology [including in the Neonatal Research Network (NRN)], anesthesiology, pathology, the clinical laboratory, and pharmacology add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the renewed NICHD MFMU Network, and accept the RFA’s capitation and participatory stipulations.

抽象的 该提案描述了俄亥俄州立大学 (OSU) 中心的团队、环境和资源， 允许其实质性地、有意义地参与并实现尤尼斯·肯尼迪·施赖弗的目标 NICHD 母胎医学中心 (MFMU) 网络。 OSU 中心表现强劲 以及由于其科学专业知识而进行临床和转化研究的经验，优秀 基础设施和制度支持。该提案的研究团队由医学博士 Maged Costantine 领导， William 担任 MFMU 网络中心母胎医学部门主任和 PI Grobman，医学博士、工商管理硕士，担任 MFMU 妇产科副主席和候补 PI 网络中心。除了 MFMU 网络内的生产力之外，PI 和备用 PI 还带来了 在研究设计、招募、数据分析和结果传播方面拥有丰富的经验。他们的研究 关注产科护理和结果、围产期药理学、流行病学、临床试验设计、 转化研究是互补的，将成为该网络的一项资产。 OSU 中心将招募 研究参与者来自 2 个医疗中心的不同种族和民族人群，总共 每年有超过 10,000 名新生儿出生，其中许多是在规定范围内接受产前护理的高危人群 两个系统。我们中心的护士协调员 Anna Bartholomew（MPH、RN、BSN、CCRP）领导着一个大团队 能够在拥有 32 名研究人员的研究组织中招募和留住患者的研究人员数量 拥有多年 MFMU 网络经验；在多项其他合作研究中具有明显的经验 设置，包括 NICHD nuMoM2b 网络、NICHD 母婴治疗精度 (MPRINT)、NIH 长期帮助消除成瘾 (HEAL) 以及 NIH 研究新冠病毒以增强 恢复（RECOVER）倡议；以及参与其他多站点计划，例如北美 胎儿治疗网络、俄亥俄州更好的出生结果和俄亥俄州围产期研究网络。我们另外 受益于强大的生物信息学结构和多功能电子病历系统，可捕获 产前、产中和产后数据，授权研究人员可以随时获取数据 研究对象资格的查询和通知；一群杰出的产科超声医师和 围产期流行病学家；以及由 CTSA 拨款支持的成熟研究基础设施 全国儿童医院。我们的卫星站点，位于代顿的迈阿密谷医院，拥有出色的记录 之前网络周期中的招聘、完善的研究文化以及 MFMU 的宏伟目标 网络参与。我们与俄勒冈州立大学新生儿科的强有力的临床和研究合作[包括在 新生儿研究网络 (NRN)]、麻醉学、病理学、临​​床实验室和药理学添加 我们的应用程序的优势。我们期待继续我们的服务传统、强劲的业绩和 NICHD MFMU 网络的创新，并接受 RFA 的按人头付费和参与性规定。