NICHD maternal fetal medicine units network

摘要 本提案描述了俄亥俄州州立大学（OSU）中心的团队、环境和资源， 允许它实质性和有意义地参与，并实现目标，尤尼斯肯尼迪施莱佛 NICHD产妇胎儿医学单位网络。俄勒冈州立大学中心表现出了强劲的业绩 由于其科学专业知识，在进行临床和转化研究方面具有丰富的经验， 基础设施和机构支持。该提案的研究小组由Maged Costantine博士领导， 她是MFMU网络中心的母胎医学和PI部门主任， Grobman，MD，MBA，担任产科/妇科副主任和MFMU的候补PI 网络中心。除了MFMU网络内的生产力外，PI和备用PI还带来了 在研究设计、招募、数据分析和结果传播方面拥有丰富的经验。他们的研究 关注产科护理和结局的差异，围产期药理学，流行病学，临床试验设计， 和翻译研究是互补的，将是网络的资产。OSU中心将招募 研究参与者来自2个医疗中心的不同种族和民族人群， 每年有10 000多名新生儿，其中许多是在产前护理期间接受产前护理的高危人群。 两制我们中心的护士协调员，安娜巴塞洛缪，MPH，RN，BSN，CCRP，领导一个大集团 研究人员能够招募和留住患者的研究组织，有32 在MFMU网络的多年经验;在多个其他合作研究的可证明的经验 包括NICHD nuMoM 2b网络、NICHD孕产妇和儿科治疗精确度 （MPRINT），NIH帮助结束长期成瘾（HEAL），以及NIH研究COVID以增强 恢复（RECOVER）倡议;并参与其他多地点倡议，如北美 胎儿治疗网络，俄亥俄州更好的出生结果，和俄亥俄州围产期研究网络。我们另外 受益于强大的生物信息学结构和多功能的电子病历系统， 产前、产时和产后数据，授权研究人员可随时获得数据 询问和通知研究受试者的资格;一个特殊的产科超声波检查员小组， 围产期流行病学家;和一个成熟的研究基础设施，由CTSA赠款支持， 全国儿童医院。我们的卫星站点，代顿的迈阿密山谷医院， 在以前的网络周期，完善的研究文化，并为MFMU雄心勃勃的目标招聘 网络参与。我们与俄勒冈州立大学口腔医学院（OSU）的强大临床和研究合作[包括在 新生儿研究网络（NRN）]、麻醉学、病理学、临床实验室和药理学 我们的应用程序的优势。我们期待着继续我们的服务传统，强大的性能， 在更新的NICHD MFMU网络的创新，并接受RFA的人头和参与规定。

ABSTRACT This proposal describes the team, environment, and resources of The Ohio State University (OSU) Center that allow it to substantively and meaningfully participate in, and meet the objectives of, the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The OSU Center has demonstrated strong performance and experience in conducting clinical and translational research due to its scientific expertise, excellent infrastructure, and institutional support. The research team for this proposal is led by Maged Costantine, MD, who serves as Division Director for Maternal-Fetal Medicine and PI for the MFMU Network Center, and William Grobman, MD, MBA, who serves as Vice-Chair for the Department of OB/GYN and Alternate PI for the MFMU Network Center. In addition to their productivity within the MFMU Network, both the PI and Alternate PI bring extensive experience in study design, recruitment, data analysis, and dissemination of results. Their research foci on disparities in obstetric care and outcomes, perinatal pharmacology, epidemiology, clinical trial design, and translational research is complementary and will be an asset to the Network. The OSU Center will recruit study participants from racially and ethnically diverse populations at 2 medical centers with a combined total of more than 10,000 annual births, many of which are to high-risk individuals who receive prenatal care within the two systems. Our Center’s Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of research staff capable of recruiting and retaining patients in the setting of a research organization that has 32 of years of experience in the MFMU Network; demonstrable experience in multiple other cooperative research settings, including the NICHD nuMoM2b Network, NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT), NIH Helping to End Addiction Long-term (HEAL), and the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative; and engagement with other multi-site initiatives such as the North American Fetal Treatment Network, Ohio Better Birth Outcomes, and Ohio Perinatal Research Network. We additionally benefit from a robust bioinformatics structure and versatile Electronic Medical Record System that captures antepartum, intrapartum, and postpartum data and is readily available to authorized research personnel for data query and notification of research subjects’ eligibility; an extraordinary group of obstetrical sonographers and perinatal epidemiologists; and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite site, Miami Valley Hospital in Dayton, has an outstanding record of recruitment in the prior Network cycles, well-established research culture, and ambitious goals for MFMU Network participation. Our strong clinical and research collaboration with OSU neonatology [including in the Neonatal Research Network (NRN)], anesthesiology, pathology, the clinical laboratory, and pharmacology add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the renewed NICHD MFMU Network, and accept the RFA’s capitation and participatory stipulations.