NICHD Maternal Fetal Medicine Units Network
NICHD 母胎医学单位网络
基本信息
- 批准号:9891074
- 负责人:
- 金额:$ 26.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-04-08 至 2021-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAmericanBioinformaticsBiologicalBirthClinicalClinical DataClinical ResearchClinical TrialsClinical Trials NetworkCytomegalovirusData AnalysesData CollectionDevelopmentDiagnosisDiscipline of obstetricsEnrollmentEnvironmentEpidemiologistEpidemiologyExtramural ActivitiesFacultyFollow-Up StudiesFundingFunding OpportunitiesGoalsGrantHepatitis C virusHigh Risk WomanHospitalsInfant MortalityInsulinJournalsLeadershipLow Birth Weight InfantManuscriptsMaternal-Fetal Medicine Units NetworkMedicalMedical centerMetforminNational Institute of Child Health and Human DevelopmentNon-Insulin-Dependent Diabetes MellitusNulliparityObservational StudyOhioParticipantPatient RecruitmentsPatientsPediatric HospitalsPerformancePerinatalPerinatal mortality demographicsPopulationPopulation HeterogeneityPositioning AttributePreventionPrincipal InvestigatorProductivityProtocols documentationPublicationsRandomized Clinical TrialsReportingResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesServicesSiteStaff DevelopmentStructureSymbiosisSystemTraining and EducationTranslatingTranslational ResearchU-Series Cooperative AgreementsUniversitiesWorkadverse pregnancy outcomebasebench to bedsideclinical careclinical centerclinical infrastructureclinical investigationclinically relevantdata qualitydesignethnic diversityexperiencefaculty researchfetalimprovedinfant morbidityinnovationmemberperinatal medicineprematureprotocol developmentpublic health relevanceracial and ethnicracial diversityrandomized trialrecruitrepositoryresearch and developmentresponsesample collectionsociodemographicssupport networksystems research
项目摘要
DESCRIPTION (provided by applicant): This proposal is the application of The Ohio State University (OSU) for continued participation in the NICHD Maternal Fetal Medicine Units (MFMU) Network. The current application describes our team, environment and resources to meet the objectives of the Network. Our newly energized team has a strong commitment to continue and expand our high level of performance in the Network since 1992. We have a strong experience in conducting clinical and translational research. Dr. Catalin Buhimschi was recruited to the OSU Wexner Medical Center in 2013. As Ohio State's Alternate Principal Investigator (PI) since 2014, he assumed local leadership, energized our research team, worked closely with Network's Publication Committee, and co-authored a concept presentation to the Steering Committee. The final cumulative performance report lists OSU as 1st in recruitment for HCV, 4th in ALPS, 6th in CMV trials, and 3rd - 4th best for overall recruitment. In the current application Dr. Buhimschi will serve as PI and work with Dr. Mark Landon, an established Network investigator, as Alternate PI. The OSU Network will recruit study participants from diverse populations at 3 medical centers with a combined total of more than 15,000 annual births. We have a large group of faculty & research staff capable of recruiting patients in the setting of an excellent research organization enhanced by 24 years of experience in the MFMU, participation in the NICHD Nulliparous Network, and memberships in the North American Fetal Treatment Network, and Ohio Perinatal Research Network (OPRN) - a large regional perinatal research repository with a state-of-the-art data collection system. We benefit from a robust bioinformatics structure, an extraordinary group of obstetrical sonographers, perinatal epidemiologists, and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children's Hospital. Our satellite, Miami Valley Hospital in Dayton has an outstanding record of recruitment in the most recent Network cycle, 2011- 2016. Good Samaritan Hospital, the largest maternity service in Ohio, has worked closely with OSU faculty in statewide projects, has a well-established research culture and an ambitious agenda for MFMU Network participation. Our relationship with Nationwide Children's Hospital in clinical care and research has never been stronger, and includes a unique symbiosis with Center for Perinatal Research. We look forward to continuing our tradition of service and innovation in the next cycle of the NICHD MFMU Network. Our goal is to continue to be leaders in protocol development, recruitment, start-up and completion, data analysis, manuscript publication in top journals and support to the Network's tasks across all research protocols and centers.
描述(由申请人提供):本提案是俄亥俄州州立大学(OSU)继续参与NICHD母胎医学单位(MFMU)网络的申请。当前的应用程序描述了我们的团队,环境和资源,以满足网络的目标。我们新的充满活力的团队有一个坚定的承诺,继续和扩大我们的高水平的性能在网络自1992年以来。我们在开展临床和转化研究方面拥有丰富的经验。Catalin Buhimschi博士于2013年被OSU Wexner医疗中心招募。作为俄亥俄州的候补首席研究员(PI)自2014年以来,他承担了当地的领导,激励我们的研究团队,与网络的出版委员会密切合作,并共同撰写了一个概念介绍指导委员会。最终的累积性能报告将OSU列为HCV招募的第1名,ALPS的第4名,CMV试验的第6名,以及总体招募的第3 - 4名。在本申请中,Buhimschi博士将担任PI,并与Mark Landon博士(一位成熟的网络研究者)合作,作为替代PI。OSU网络将从3个医疗中心的不同人群中招募研究参与者,每年出生的总人数超过15,000人。我们有一个庞大的教师和研究人员能够招募病人在一个优秀的研究组织的设置增强了24年的经验,在MFMU,在NICHD Nulliparous网络的参与,并在北美胎儿治疗网络的成员资格,和俄亥俄州围产期研究网络(OPRN)-一个大型的区域围产期研究存储库与国家的最先进的数据收集系统。我们受益于一个强大的生物信息学结构,产科超声医师,围产期流行病学家的非凡群体,以及与全国儿童医院共享的CTSA赠款支持的成熟研究基础设施。我们的卫星医院,代顿的迈阿密山谷医院在最近的网络周期(2011 - 2016年)中有着出色的招聘记录。好撒玛利亚医院是俄亥俄州最大的妇产服务机构,在全州范围的项目中与俄勒冈州立大学的教师密切合作,拥有完善的研究文化和雄心勃勃的MFMU网络参与议程。我们与全国儿童医院在临床护理和研究方面的关系从未如此紧密,包括与围产期研究中心的独特共生关系。我们期待在NICHD MFMU网络的下一个周期中延续我们的服务和创新传统。我们的目标是继续成为方案开发、招募、启动和完成、数据分析、在顶级期刊上发表手稿以及支持网络在所有研究方案和中心的任务方面的领导者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maged Costantine其他文献
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{{ truncateString('Maged Costantine', 18)}}的其他基金
Developing Extracellular Vesicle Based MPRINT Translational Resource Platform for Monitoring Therapeutics Response During Pregnancy
开发基于细胞外囊泡的 MPRINT 转化资源平台,用于监测妊娠期间的治疗反应
- 批准号:
10747545 - 财政年份:2023
- 资助金额:
$ 26.62万 - 项目类别:
1/2 A randomized controlled trial of pravastatin to prevent preeclampsia in high-risk women
1/2 普伐他汀预防高危女性先兆子痫的随机对照试验
- 批准号:
10087196 - 财政年份:2019
- 资助金额:
$ 26.62万 - 项目类别:
1/2 A randomized controlled trial of pravastatin to prevent preeclampsia in high-risk women
1/2 普伐他汀预防高危女性先兆子痫的随机对照试验
- 批准号:
10705607 - 财政年份:2019
- 资助金额:
$ 26.62万 - 项目类别:
1/2 A randomized controlled trial of pravastatin to prevent preeclampsia in high-risk women
1/2 普伐他汀预防高危女性先兆子痫的随机对照试验
- 批准号:
10162643 - 财政年份:2019
- 资助金额:
$ 26.62万 - 项目类别:
1/2 A randomized controlled trial of pravastatin to prevent preeclampsia in high-risk women
1/2 普伐他汀预防高危女性先兆子痫的随机对照试验
- 批准号:
10455106 - 财政年份:2019
- 资助金额:
$ 26.62万 - 项目类别:
Comprehensive evaluation of the safety and utility of pravastatin in prevention of preeclampsia in high-risk pregnant women
普伐他汀预防高危孕妇子痫前期的安全性和有效性综合评价
- 批准号:
9119186 - 财政年份:
- 资助金额:
$ 26.62万 - 项目类别:
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