Perovskite-Graphene Energy Integrating Detector for X-Ray Imaging

用于 X 射线成像的钙钛矿-石墨烯能量积分探测器

• 批准号: 10384524
• 负责人: Kendon Robert Shirley
• 金额: $ 24.7万
• 依托单位: KAIROS SENSORS LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10384524
• 关键词: Area; Attention; Charge; Consumption; Deposition; Detection; Devices; Diagnosis; Diagnostic radiologic examination; Dimensions; Discrimination; Disease; Early Diagnosis; Electronics; Image; Image Enhancement; Injury; Length; Mammography; Maps; Measures; Medical Imaging; Metals; Microscopy; Noise; Optics; Patient-Focused Outcomes; Patients; Performance; Phase; Photons; Preparation; Process; Property; Raman Spectrum Analysis; Recovery; Roentgen Rays; Scanning Electron Microscopy; Selenium; Semiconductors; Signal Transduction; Spectrum Analysis; Technology; Thick; Time; Tissues; Transistors; Tube; Woman; X ray diffraction analysis; base; commercialization; cost; density; detector; graphene; imaging detector; imaging system; improved; innovation; ionization; millisecond; novel; perovskite; printed circuit board; prototype; response; sensor; tau Proteins; tomosynthesis

Approximately 12% of women have a false-positive result after one mammogram, and 60% have a false positive after ten yearly mammograms - resulting in the need for secondary screenings. The cost of unnecessary secondary screenings, often due to the inability to differentiate between healthy and unhealthy tissue with the desired accuracy, has been calculated to be $4 billion per year. Increasing the sensitivity of low exposure per frame X-ray detectors will reduce the need for unnecessary secondary screenings and improve patient outcomes via enhanced image quality. Image quality largely depends on the response of the detector's sensor to X-rays, aka sensitivity. Sensitivity is dependent on the sensor's ability to generate as many X-ray liberated charge carriers as possible that will contribute towards the signal acquisition for an image. Sometimes this is referred to as the sensor's average ionization energy or internal gain. Direct conversion sensors (semiconductors), such as amorphous selenium (a-Se), have a low internal gain – making low exposure per frame applications like tomosynthesis challenging to generate signals above the noise of the electronics. Recently, new materials such as organic/inorganic metal halide perovskites have drawn attention for their considerable stopping power of X-rays, efficient charge transfer properties, and ease of material synthesis. Additionally, graphene materials are known for their photoconductive gain and comfort of integration with conventional electronic platforms. Kairos Sensors LLC proposes a multi-pixel perovskite-graphene energy integrating detector for X-ray imaging with vastly improved sensitivity and low power consumption for this Phase I proposal. Kairos Sensors' innovation utilizes solution-processed perovskites grown directly from the conductive graphene lattice and has shown ultra-high sensitivity with prototype single-pixel perovskite-graphene devices. This project aims to achieve a multi-pixel perovskite-graphene detector with high sensitivity via optimized configuration of material composition and pixel dimensions. Phase I will focus on demonstrating an extremely sensitive multi-pixel perovskite-graphene detector. Phase II will focus on a more extensive pixel array and take images in preparation for commercialization.

大约 12% 的女性在进行一次乳房 X 光检查后出现假阳性结果，60% 的女性出现假阳性结果 每年进行十年乳房 X 光检查后呈阳性 - 导致需要进行二次筛查。不必要的成本 二次筛查，通常是由于无法区分健康组织和不健康组织 据计算，所需的准确度为每年 40 亿美元。提高每次低曝光的灵敏度 框架 X 射线探测器将减少不必要的二次筛查并改善患者治疗结果 通过增强图像质量。 图像质量很大程度上取决于探测器传感器对 X 射线的响应，也称为灵敏度。 灵敏度取决于传感器产生尽可能多的 X 射线释放电荷载流子的能力 这将有助于图像的信号采集。有时这被称为传感器的 平均电离能或内部增益。直接转换传感器（半导体），如非晶 硒 (a-Se) 具有较低的内部增益 – 使得每帧曝光较低的应用，例如断层合成 生成高于电子设备噪声的信号具有挑战性。 近年来，有机/无机金属卤化物钙钛矿等新材料因其优异的性能而引起人们的关注。 相当大的 X 射线阻止能力、高效的电荷转移特性以及易于材料合成。 此外，石墨烯材料以其光电导增益和与其他材料集成的舒适度而闻名。 传统电子平台。 Kairos Sensors LLC 提出了一种多像素钙钛矿-石墨烯能量 用于 X 射线成像的集成探测器，该阶段的灵敏度大大提高且功耗低 我提议。 Kairos Sensors 的创新利用直接从导电材料生长的溶液处理钙钛矿 石墨烯晶格，并通过原型单像素钙钛矿-石墨烯器件表现出超高灵敏度。 该项目旨在通过优化实现高灵敏度的多像素钙钛矿-石墨烯探测器 材料成分和像素尺寸的配置。 第一阶段将重点展示极其灵敏的多像素钙钛矿-石墨烯探测器。 第二阶段将专注于更广泛的像素阵列并拍摄图像，为商业化做准备。