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4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries

4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries
4/4 推动拉丁美洲和非洲血统中严重精神疾病的基因发现
批准号：
10383005
负责人：
NELSON B. FREIMER
金额：
$16.14万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
未结题
起止时间：
2020-09-14 至 2025-07-31
来源：
https://reporter.nih.gov/project-details/10383005
关键词：
Administrative SupplementAfricanAfrican AmericanAliquotAwardBiologicalBiological Specimen BanksBipolar DisorderBlood specimenBudgetsCaliforniaCollaborationsCollectionColombiaCountyDNADNA sequencingDataDatabasesEnvironmentFundingFutureGenesGeneticGenetic ResearchGenetic VariationGenomicsGrantInformaticsInstitutesInternationalLatin AmericanLos AngelesMental disordersNational Institute of Mental HealthNeurosciencesParentsParticipantPoliciesPopulationProcessResearch PersonnelResourcesRiskSamplingSchizophreniaShippingShipsSiteSouth AfricaSouth AmericaSystemUnderrepresented PopulationsUnited States National Institutes of Healthcostdata sharinggenetic analysisgenetic architecturegenomic datagenomic platformhealth disparityparent projectprogramspsychiatric genomicspsychogeneticsrecruitrepositoryresponsesevere mental illness

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英文摘要
Project Summary This proposal is for a supplement to support the aims of the Populations Underrepresented in Mental illness Association Studies (PUMAS) Project, an international collaboration of investigators from the US, South America and Africa focused on large-scale psychiatric genetic research in populations of Latin-American and African descent. PUMAS aims to discover new genes for schizophrenia and bipolar disorder; it will dramatically increase the diversity of genetic discovery efforts, an important step towards reducing health disparities; and it will expand the scope of psychiatric genomics by discovering similarities and differences in genetic architecture of schizophrenia and bipolar disorder across diverse ancestries and environments. The sheer scope of the project will strain the resources of existing biosample repositories. This supplement will advance the overall project by supporting the processing at the UCLA Neuroscience Genomics Core (UNGC) biosample repository of samples from a portion of project participants (those in Coastal Colombia and Southern California). The supplement will support the UNGC in transporting samples to the repository, extracting and storing DNA, shipping DNA to the project’s genomics core, and maintaining the informatics system that will enable it to provide samples to qualified investigators.
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A Latin American biobank for large-scale genetics research on severe mental illness
4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries
A Latin American biobank for large-scale genetics research on severe mental illness
4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries
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