4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries

4/4 推动拉丁美洲和非洲血统中严重精神疾病的基因发现

• 批准号: 10383005
• 负责人: NELSON B. FREIMER
• 金额: $ 16.14万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10383005
• 关键词: Administrative Supplement; African; African American; Aliquot; Award; Biological; Biological Specimen Banks; Bipolar Disorder; Blood specimen; Budgets; California; Collaborations; Collection; Colombia; County; DNA; DNA sequencing; Data; Databases; Environment; Funding; Future; Genes; Genetic; Genetic Research; Genetic Variation; Genomics; Grant; Informatics; Institutes; International; Latin American; Los Angeles; Mental disorders; National Institute of Mental Health; Neurosciences; Parents; Participant; Policies; Population; Process; Research Personnel; Resources; Risk; Sampling; Schizophrenia; Shipping; Ships; Site; South Africa; South America; System; Underrepresented Populations; United States National Institutes of Health; cost; data sharing; genetic analysis; genetic architecture; genomic data; genomic platform; health disparity; parent project; programs; psychiatric genomics; psychogenetics; recruit; repository; response; severe mental illness

Project Summary This proposal is for a supplement to support the aims of the Populations Underrepresented in Mental illness Association Studies (PUMAS) Project, an international collaboration of investigators from the US, South America and Africa focused on large-scale psychiatric genetic research in populations of Latin-American and African descent. PUMAS aims to discover new genes for schizophrenia and bipolar disorder; it will dramatically increase the diversity of genetic discovery efforts, an important step towards reducing health disparities; and it will expand the scope of psychiatric genomics by discovering similarities and differences in genetic architecture of schizophrenia and bipolar disorder across diverse ancestries and environments. The sheer scope of the project will strain the resources of existing biosample repositories. This supplement will advance the overall project by supporting the processing at the UCLA Neuroscience Genomics Core (UNGC) biosample repository of samples from a portion of project participants (those in Coastal Colombia and Southern California). The supplement will support the UNGC in transporting samples to the repository, extracting and storing DNA, shipping DNA to the project’s genomics core, and maintaining the informatics system that will enable it to provide samples to qualified investigators.

项目摘要 这项建议是一项补充，以支持在联合国系统内任职人数不足的人口的目标。 精神疾病协会研究（PUMAS）项目，一个国际合作， 来自美国、南美和非洲的研究人员专注于大规模的精神病遗传学研究， 对拉丁美洲和非洲裔人口的研究。PUMAS旨在发现新的 精神分裂症和双相情感障碍的基因;它将大大增加遗传多样性 发现工作，减少健康差距的重要一步;它将扩大 精神病基因组学的范围，通过发现遗传结构的相似性和差异 精神分裂症和双相情感障碍在不同的祖先和环境中。庞大 该项目的规模将使现有生物样本储存库的资源紧张。这种补充剂 将通过支持加州大学洛杉矶分校神经科学的处理来推进整个项目 基因组学核心（UNGC）生物样本储存库，储存部分项目参与者的样本 （哥伦比亚沿海和加州南部）。该补编将支持联合国全球契约， 将样本运送到储存库，提取和储存DNA，将DNA运送到项目的 基因组学核心，并维护信息系统，使其能够提供样本， 合格的调查员。