A Latin American biobank for large-scale genetics research on severe mental illness

拉丁美洲生物库，用于严重精神疾病的大规模遗传学研究

• 批准号: 10386289
• 负责人: NELSON B. FREIMER
• 金额: $ 12.63万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-07 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10386289
• 关键词: Administrative Supplement; Aliquot; Award; Blood specimen; Budgets; Collection; Colombia; Communities; DNA; DNA Repository; Data; Databases; Diagnosis; Funding; Genetic Research; Genetic study; Genomics; Grant; Individual; Latin America; Latin American; Mental disorders; National Institute of Mental Health; Neurosciences; Parents; Participant; Phenotype; Policies; Population; Population Control; Process; Protocols documentation; Quality Control; Research Personnel; Resources; Sampling; Ships; Site; Time; United States National Institutes of Health; base; biobank; data sharing; expectation; genetic architecture; genome-wide; parent grant; parent project; programs; psychogenetics; recruit; repository; severe mental illness

PROJECT SUMMARY / ABSTRACT This supplement to NIMH grant R01 MH123157 (Latin American Biobank of Severe Mental Illness [LAB-SMI]) will enable the UCLA investigators of this project to establish a DNA repository for this project. The parent project aims to reverse the underrepresentation of populations from Latin America in psychiatric genetic research. It will do so by recruiting and phenotyping 92,000 new participants from Colombia (42,000 individuals diagnosed with SMI and 50,000 population controls) and obtaining blood samples from these participants that will provide the DNA for genome wide genetic studies. The supplement will fund the investigators to augment the processes proposed in the parent grant for DNA extraction and storage so as to: (1) obtain larger amounts of high-quality DNA; (2) store and track the DNA samples in a way that will facilitate the use of the samples beyond the specific aims of the parent grant; (3) make aliquots of DNA available to qualified investigators based on protocols established with NIMH program staff. The supplement will add to the value of the parent project as a unique resource for the first well-powered genetic studies of psychiatric disorders in populations of Latin American ancestry and for exploring the genetic architecture of SMI phenotypes.

项目概要/摘要 本补充对 NIMH 拨款 R01 MH123157（拉丁美洲严重精神疾病生物库 [LAB-SMI]） 将使该项目的加州大学洛杉矶分校研究人员能够为此项目建立 DNA 存储库。父项目 旨在扭转拉丁美洲人群在精神病学基因研究中代表性不足的问题。它将 为此，我们招募了来自哥伦比亚的 92,000 名新参与者（42,000 名被诊断患有 SMI 和 50,000 名人口对照），并从这些参与者那里获取血液样本，以提供 用于全基因组遗传学研究的 DNA。该补充品将资助研究人员扩大流程 母基金中提议进行 DNA 提取和储存，以便：(1) 获得大量高质量的 DNA 脱氧核糖核酸; (2)以有利于样本超出特定用途的方式存储和追踪DNA样本。 家长补助金的目的； (3) 根据方案向合格的研究人员提供 DNA 等分试样 与 NIMH 项目工作人员共同建立。该补充项目将作为独特的项目增加父项目的价值 拉丁美洲人群精神疾病的第一个强有力的遗传学研究的资源 祖先并探索 SMI 表型的遗传结构。