A Latin American biobank for large-scale genetics research on severe mental illness

项目摘要/摘要 NIMH补助金R01 MH123157(拉丁美洲严重精神疾病生物库[LAB-SMI]) 将使加州大学洛杉矶分校的研究人员能够为这个项目建立一个DNA储存库。父项目 旨在扭转拉丁美洲人口在精神遗传学研究中代表性不足的情况。会的 为此，从哥伦比亚招募92,000名新参与者并对其进行表型分析(42,000名确诊为 SMI和50,000人口对照)，并从这些参与者那里获取血液样本，这将提供 用于全基因组遗传学研究的DNA。这项补充资金将资助调查人员加强调查过程。 建议在父母拨款中提取和储存DNA，以便：(1)获得更多的高质量 DNA；(2)储存和跟踪DNA样本，以便于使用特定范围以外的样本 父母拨款的目的；(3)根据协议向合格的研究人员提供等量DNA 与NIMH项目工作人员一起建立。补充内容将增加父项目作为一个独特项目的价值 拉丁美洲人口中精神障碍的第一个强有力的遗传学研究的资源 并用于探索SMI表型的遗传结构。

PROJECT SUMMARY / ABSTRACT This supplement to NIMH grant R01 MH123157 (Latin American Biobank of Severe Mental Illness [LAB-SMI]) will enable the UCLA investigators of this project to establish a DNA repository for this project. The parent project aims to reverse the underrepresentation of populations from Latin America in psychiatric genetic research. It will do so by recruiting and phenotyping 92,000 new participants from Colombia (42,000 individuals diagnosed with SMI and 50,000 population controls) and obtaining blood samples from these participants that will provide the DNA for genome wide genetic studies. The supplement will fund the investigators to augment the processes proposed in the parent grant for DNA extraction and storage so as to: (1) obtain larger amounts of high-quality DNA; (2) store and track the DNA samples in a way that will facilitate the use of the samples beyond the specific aims of the parent grant; (3) make aliquots of DNA available to qualified investigators based on protocols established with NIMH program staff. The supplement will add to the value of the parent project as a unique resource for the first well-powered genetic studies of psychiatric disorders in populations of Latin American ancestry and for exploring the genetic architecture of SMI phenotypes.