Elucidating individual and neighborhood factors associated with nonalcoholic fatty liver disease (NAFLD)

阐明与非酒精性脂肪肝（NAFLD）相关的个人和社区因素

• 批准号: 10381399
• 负责人: Salma Shariff-Marco
• 金额: $ 13.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-16 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381399
• 关键词: Address; Adult; Advisory Committees; Affect; Age; Alcohol consumption; Algorithms; Area; Asian Americans; Awareness; Behavioral; California; Cancer Burden; Cancer Etiology; Cessation of life; Chronic Disease; Chronic Hepatitis B; Chronic Hepatitis C; Cirrhosis; Clinical; Conflict (Psychology); Data; Development; Diabetes Mellitus; Diagnostic tests; Dyslipidemias; Early identification; Electronic Health Record; Environment; Ethnic Origin; Exposure to; Federally Qualified Health Center; Fibrosis; Funding; Future; HIV Infections; Hawaii; Health; Health system; Healthcare Systems; Hepatitis B Virus; Hepatitis C; Heterogeneity; High Prevalence; Hispanic Americans; Housing; Hypertension; Incidence; Individual; Information Dissemination; Information Systems; Insulin Resistance; Integrated Health Care Systems; International Classification of Disease Codes; Intervention; Iron; K-Series Research Career Programs; Malignant Neoplasms; Malignant neoplasm of liver; Metabolic syndrome; Morbidity - disease rate; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Physicians; Polycystic Ovary Syndrome; Population; Population Density; Population Heterogeneity; Positioning Attribute; Prospective cohort study; Race; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; San Francisco; Social Environment; Socioeconomic Status; Testing; United States; Woman; biomedical referral center; built environment; cancer prevention; career; chronic liver disease; clinical Diagnosis; cohort; community partnership; diagnostic screening; disease disparity; disorder risk; gut microbiota; high risk; member; men; modifiable risk; mortality; non-alcoholic fatty liver disease; noninvasive diagnosis; novel; predictive tools; racial and ethnic; racial and ethnic disparities; sex; skills; social; social health determinants; socioeconomics

Proposed Supplement Research Project: Elucidating individual and neighborhood factors associated with nonalcoholic fatty liver disease (NAFLD) Abstract: While overall cancer rates are declining in the United States (U.S.), liver cancer incidence has more than tripled in the last four decades, making it the fastest rising cancer in the U.S. Liver cancer mortality is the fifth and seventh leading causes of cancer death among men and women, respectively. Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the U.S. adult population, has rapidly become a leading cause of chronic liver disease, and is increasingly recognized as an important risk factor for developing liver cancer. Identifying and mitigating exposure to potentially modifiable risk factors can reduce the morbidity and mortality related to long-term sequelae of NAFLD, including cirrhosis and liver cancer. Established risk factors for NAFLD include obesity, type 2 diabetes, older age, hypertension, dyslipidemia, and metabolic syndrome. Studies have suggested that neighborhood factors may be associated with NAFLD development and progression to liver cancer through insulin resistance and altered gut flora. However, no studies have examined the relationship between social and built environment attributes and NAFLD. We propose a prospective cohort study of approximately 2 million patients from three healthcare systems in California (UCSF Health System and San Francisco Health Network) and Hawaii (Kaiser Permanente Hawaii) to address these research gaps. Leveraging this racially/ethnically and socioeconomically diverse cohort, this proposed study will examine multilevel risk factors (social, behavioral, clinical, and neighborhood) associated with NAFLD, including identification of those with previously undiagnosed NAFLD. We will engage with the San Francisco Cancer Initiative (SFCAN), a local community partnership focused on reducing cancer burden in San Francisco, for interpretation and dissemination of results. Identifying individual- and neighborhood-level risk factors are relevant for future targeted interventions that will be critical to address these disparities.

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