Effects of Acculturation on Gestational Biology in Mexican-American Pregnant Women

文化适应对墨西哥裔美国孕妇妊娠生物学的影响

• 批准号: 10386595
• 负责人: Molly Maurer Fox
• 金额: $ 8.81万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386595
• 关键词: Acculturation; Address; Administrative Supplement; Affect; American; Anthropology; Attitude; Award; Behavioral; Biological; Biological Factors; Biological Markers; Biological Sciences; Biology; COVID-19; COVID-19 pandemic; Child; Child Health; Chronic Disease; Consumption; Country; Development; Development Plans; Developmental Biology; Disadvantaged; Disease; Early identification; Ecology; Education; Educational process of instructing; Elements; Endocrine; Ensure; Environment; Epidemiology; Equation; Exhibits; Face; Factor Analysis; Faculty; Failure; Fetal Development; Fetus; Foundations; Foxes; Funding; Future; Generations; Glucose; Goals; Health; Health Status; Hispanic Americans; Hispanics; Human; Human Biology; Immigrant; Immune; Individual; Insulin; Investigation; K-Series Research Career Programs; Laboratories; Latina; Latino; Lead; Leptin; Life; Light; Link; Lipids; Literature; Maternal and Child Health; Measurement; Measures; Mentored Research Scientist Development Award; Mentors; Metabolic; Methods; Mexican; Mexican Americans; Minority Groups; Modeling; Mollies; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Paper; Peer Review; Phenotype; Predisposition; Pregnancy; Pregnant Women; Prevention strategy; Process; Property; Psychometrics; Psychoneuroimmunology; Public Health; Publishing; Research; Research Activity; Research Personnel; Resources; Risk; Role; Social Environment; Stress; Structure; Testing; Time; Training; Training Activity; Universities; Vulnerable Populations; Wages; Woman; base; biobehavior; biological systems; career; career development; cohort; disorder risk; experience; fetal; fetal programming; health disparity; improved; inclusion criteria; instrument; interest; intergenerational; laboratory facility; migration; motherhood; next generation; offspring; population based; pregnant; prenatal; prenatal stress; preventive intervention; prospective; psychologic; residence; social; social culture; study population; transmission process

ABSTRACT THIS PROPOSAL seeks additional salary support to compensate for career development activities missed due to COVID-19 disruptions from campus and daycare closures. There are no proposed changes to the research plan. RESEARCH SUMMARY. An important issue relates to the underlying cause(s) of epidemiologic observations that Latino immigrants exhibit a progressive decline in health (particularly obesity) over time and across generations. I suggest that the intergenerational escalation in obesity rates could be a consequence of acculturation-related biological changes in women. During pregnancy, these changes may be transmitted to the next generation (fetus) to influence offspring phenotypes that determine susceptibility for obesity (adiposity). A necessary step towards investigating this hypothesis is determining whether acculturation is associated with changes in aspects of gestational biology involved in fetal programming of adiposity. Also, I suggest that inconsistencies in the acculturation-health literature may relate to limitations of operationalization of the acculturation construct and failure to consider the modifying role of social context. Findings from this project will reveal new information about health status of vulnerable populations, which could lead to new avenues for early identification of at-risk individuals and prevention strategies to limit intergenerational perpetuation of disadvantage and poor health. I am on track to complete all the original K01 project aims by end of the award period. I already acquired NIDDK R03 funding and published 12 papers during my K01 period, with 2 more in peer review. ENVIRONMENT SUMMARY. At UCLA, I have my own biological laboratory located in the Life Sciences building, where I can process and store biosamples collected in my K01 research activities. Based in the UCLA Department of Anthropology and the Cousins Center for Psychoneuroimmunology, I have myriad resources, including an inter-disciplinary team of senior investigators to provide an intellectually productive environment, research staff, office, and laboratory facilities, and experiential education in state-of-the-art methods in human biology. CANDIDATE SUMMARY. I am primarily interested in the concepts of biological embedding of socio-ecological conditions, and the fetal origins of health and disease paradigm. My career goal is to become an independent investigator in human developmental biology with R01 funding, addressing key questions related to how an individual’s social and environmental ecology influences biological systems, and how biological links between generations affect the development of homeostatic mechanisms associated with chronic disease risk. CAREER DEVELOPMENT PLAN SUMMARY. I conducted formal coursework during Years 1-2 of the K01 award period. I am mentored by a team of prominent experts in their respective fields, led by Profs. Pathik Wadhwa (pre-transition of K-award from UCI to UCLA) and Christine Dunkel Schetter (post transition), leaders in the field of prenatal stress biology and fetal origins of disease, and receive specialized short-term training from a team of distinguished faculty at other universities.

摘要 本建议书寻求额外的工资支持，以补偿因以下原因而错过的职业发展活动： COVID-19导致校园和日托关闭。研究计划未提出变更。 研究总结。一个重要的问题涉及流行病学观察结果的根本原因， 随着时间的推移和几代人的推移，拉丁美洲移民的健康状况（特别是肥胖）逐渐下降。我 这表明肥胖率的代际升级可能是与文化适应有关的结果。 女性的生理变化。在怀孕期间，这些变化可能会传递给下一代（胎儿） 以影响决定肥胖症（肥胖症）易感性的后代表型。的一个必要步骤 调查这一假设是确定文化适应是否与某些方面的变化有关， 妊娠生物学参与胎儿肥胖的编程。此外，我建议， 文化适应-健康文献可能与文化适应结构的可操作性的局限性有关， 未能考虑社会背景的修改作用。该项目的发现将揭示新的信息 关于脆弱人口的健康状况，这可能导致早期识别风险的新途径， 个人和预防战略，以限制弱势和健康状况不佳的代际延续。我是 按计划在授予期结束前完成K01项目的所有原始目标。我已经获得了NIDDK R03 在我的K01期间资助并发表了12篇论文，其中2篇在同行评审中。 环境摘要。在加州大学洛杉矶分校，我有自己的生物实验室，位于生命科学大楼， 在那里我可以处理和储存在我的K01研究活动中收集的生物样本。位于UCLA Department 人类学和心理神经免疫学中心，我有无数的资源，包括一个 由高级研究人员组成的跨学科小组，提供一个智力生产环境，研究人员， 办公室和实验室设施，以及人类生物学最先进方法的体验式教育。 候选人摘要。我主要感兴趣的概念，生物嵌入的社会生态 条件，以及健康和疾病范例的胎儿起源。我的职业目标是成为一个独立的 研究人员在人类发育生物学与R01的资金，解决有关的关键问题，如何 个人的社会和环境生态影响生物系统，以及生物之间的联系 几代人影响与慢性疾病风险相关的稳态机制的发展。 职业发展概要。我在K01奖的第1 - 2年进行了正式的课程工作 期我由一个由教授领导的各自领域的杰出专家组成的团队指导。巴提克·瓦德瓦 （K-award从UCI过渡到UCLA之前）和克莉丝汀邓克尔舍特（过渡后），该领域的领导者 产前压力生物学和疾病的胎儿起源，并接受专门的短期培训，从一个团队， 其他大学的杰出教师。