Effects of Acculturation on Gestational Biology in Mexican-American Pregnant Women

文化适应对墨西哥裔美国孕妇妊娠生物学的影响

• 批准号: 10386595
• 负责人: Molly Maurer Fox
• 金额: $ 8.81万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386595
• 关键词: Acculturation; Address; Administrative Supplement; Affect; American; Anthropology; Attitude; Award; Behavioral; Biological; Biological Factors; Biological Markers; Biological Sciences; Biology; COVID-19; COVID-19 pandemic; Child; Child Health; Chronic Disease; Consumption; Country; Development; Development Plans; Developmental Biology; Disadvantaged; Disease; Early identification; Ecology; Education; Educational process of instructing; Elements; Endocrine; Ensure; Environment; Epidemiology; Equation; Exhibits; Face; Factor Analysis; Faculty; Failure; Fetal Development; Fetus; Foundations; Foxes; Funding; Future; Generations; Glucose; Goals; Health; Health Status; Hispanic Americans; Hispanics; Human; Human Biology; Immigrant; Immune; Individual; Insulin; Investigation; K-Series Research Career Programs; Laboratories; Latina; Latino; Lead; Leptin; Life; Light; Link; Lipids; Literature; Maternal and Child Health; Measurement; Measures; Mentored Research Scientist Development Award; Mentors; Metabolic; Methods; Mexican; Mexican Americans; Minority Groups; Modeling; Mollies; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Paper; Peer Review; Phenotype; Predisposition; Pregnancy; Pregnant Women; Prevention strategy; Process; Property; Psychometrics; Psychoneuroimmunology; Public Health; Publishing; Research; Research Activity; Research Personnel; Resources; Risk; Role; Social Environment; Stress; Structure; Testing; Time; Training; Training Activity; Universities; Vulnerable Populations; Wages; Woman; base; biobehavior; biological systems; career; career development; cohort; disorder risk; experience; fetal; fetal programming; health disparity; improved; inclusion criteria; instrument; interest; intergenerational; laboratory facility; migration; motherhood; next generation; offspring; population based; pregnant; prenatal; prenatal stress; preventive intervention; prospective; psychologic; residence; social; social culture; study population; transmission process

ABSTRACT THIS PROPOSAL seeks additional salary support to compensate for career development activities missed due to COVID-19 disruptions from campus and daycare closures. There are no proposed changes to the research plan. RESEARCH SUMMARY. An important issue relates to the underlying cause(s) of epidemiologic observations that Latino immigrants exhibit a progressive decline in health (particularly obesity) over time and across generations. I suggest that the intergenerational escalation in obesity rates could be a consequence of acculturation-related biological changes in women. During pregnancy, these changes may be transmitted to the next generation (fetus) to influence offspring phenotypes that determine susceptibility for obesity (adiposity). A necessary step towards investigating this hypothesis is determining whether acculturation is associated with changes in aspects of gestational biology involved in fetal programming of adiposity. Also, I suggest that inconsistencies in the acculturation-health literature may relate to limitations of operationalization of the acculturation construct and failure to consider the modifying role of social context. Findings from this project will reveal new information about health status of vulnerable populations, which could lead to new avenues for early identification of at-risk individuals and prevention strategies to limit intergenerational perpetuation of disadvantage and poor health. I am on track to complete all the original K01 project aims by end of the award period. I already acquired NIDDK R03 funding and published 12 papers during my K01 period, with 2 more in peer review. ENVIRONMENT SUMMARY. At UCLA, I have my own biological laboratory located in the Life Sciences building, where I can process and store biosamples collected in my K01 research activities. Based in the UCLA Department of Anthropology and the Cousins Center for Psychoneuroimmunology, I have myriad resources, including an inter-disciplinary team of senior investigators to provide an intellectually productive environment, research staff, office, and laboratory facilities, and experiential education in state-of-the-art methods in human biology. CANDIDATE SUMMARY. I am primarily interested in the concepts of biological embedding of socio-ecological conditions, and the fetal origins of health and disease paradigm. My career goal is to become an independent investigator in human developmental biology with R01 funding, addressing key questions related to how an individual’s social and environmental ecology influences biological systems, and how biological links between generations affect the development of homeostatic mechanisms associated with chronic disease risk. CAREER DEVELOPMENT PLAN SUMMARY. I conducted formal coursework during Years 1-2 of the K01 award period. I am mentored by a team of prominent experts in their respective fields, led by Profs. Pathik Wadhwa (pre-transition of K-award from UCI to UCLA) and Christine Dunkel Schetter (post transition), leaders in the field of prenatal stress biology and fetal origins of disease, and receive specialized short-term training from a team of distinguished faculty at other universities.

抽象的 该建议寻求额外的薪水支持，以弥补由于 COVID-19受到校园和日托关闭的破坏。研究计划没有建议的更改。 研究摘要。一个重要的问题与流行病学观察的根本原因有关 随着时间的流逝，拉丁裔移民暴露了健康（尤其是肥胖）的逐步下降。我 表明肥胖率的代际升级可能是与培养有关的结果 女性的生物变化。在怀孕期间，这些变化可能会传播到下一代（胎儿） 影响确定对象性易感性（肥胖）的后代表型。迈向必要的一步 研究这一假设是确定培养是否与 胎儿编程肥胖。另外，我建议在 适应健康文献可能与适应构建的操作局限性有关， 未能考虑社会环境的修改作用。该项目的发现将揭示新信息 关于脆弱人群的健康状况，这可能会导致新的途径以早期识别高危 个人和预防策略，以限制灾难和健康状况不佳的代际永续存在。我是 在颁奖期结束时完成所有原始K01项目的目标。我已经获得了niddk r03 在我的K01期间，资金并发表了12篇论文，并在同行评审中又有2篇论文。 环境摘要。在加州大学洛杉矶分校，我有自己的生物实验室，位于生命科学大楼， 我可以在K01研究活动中处理和存储收集的生物样本的地方。位于加州大学洛杉矶分校部 人类学和堂兄心理学中心，我拥有无数的资源，包括 高级研究人员的跨学科团队提供智力生产的环境，研究人员， 办公室和实验室设施以及人类生物学最先进方法的教育。 候选摘要。我主要对社会生态学生物嵌入的概念感兴趣 状况和健康和疾病范式的胎儿起源。我的职业目标是成为独立 R01资金的人类发育生物学研究者，解决了与如何 个人的社会和环境生态学影响生物系统，以及生物学之间的联系 世代影响与慢性疾病风险相关的稳态机制的发展。 职业发展计划摘要。我在K01奖的1 - 2年内进行了正式课程。 时期。我受到教授领导的各自领域的著名专家团队的指导。 Pathik Wadhwa （从UCI到UCLA的K-Award前过渡）和Christine Dunkel Schetter（过渡后），该领域的领导者 产前压力生物学和疾病的胎儿起源，并接受一支专门的短期培训 其他大学的杰出教师。