Healing enterocutaneous fistulas using bioengineered biomaterials

使用生物工程生物材料治愈肠皮瘘

基本信息

  • 批准号:
    10384769
  • 负责人:
  • 金额:
    $ 59.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-01 至 2025-11-30
  • 项目状态:
    未结题

项目摘要

Abstract Enterocutaneous fistula (ECF) is an abnormal connection between the bowel and skin. It can be associated with discharge of pus, feces, and stomach contents and can even lead to incontinence. ECFs are referred to as surgical tragedies in the literature, as up to 85% are the result of intraabdominal surgical complications, such as missed enterotomies or anastomotic leaks. This can lead to constant leakage of enteric and fecal contents from the skin, sometimes up to many liters per day. The foul enteric contents act as a chemical irritant to the skin, leading to skin breakdown and predisposition to infection. Despite advances in treatment, ECFs still account for significant mortality of 15-20% and are associated with debilitating morbidity and substantially poor quality of life due to complex wound care, severe malnutrition, frequent infectious complications, pain, and depression. Despite advances in surgical techniques and postoperative management, no successful treatment of ECF exists today. The current treatment paradigm is unsuccessful; high fistula discharge, infection, and chronic inflammation lead to high failure and recurrence rates. This often results in prolonged intensive care unit (ICU) stays increasing health care cost which can be over $500,000 per ICU visit. We hypothesize that by using a bioengineered biomaterial that is biocompatible, non-toxic, durable, antimicrobial and regenerative, we would change the standard of medical practice in the approach to ECF. This creative approach may reduce world-wide morbidity and mortality by successfully occluding and healing any ECF, preventing fecal leakage; it will also substantially improve the quality of life of the patient and reduce the need for repeated interventions and X-ray imaging. We aim to make a paradigm shift in the treatment of potentially fatal ECF using a minimally invasive blood-derived biomaterial-based platform to occlude the fistulous tract using groundbreaking injectable shear- thinning platelet-rich gels. We will engineer the blood derived biomaterial to include antimicrobial, adhesive, and regenerative components that will be tested in vitro and in vivo (Aim 1) and we will evaluate the optimized biomaterial with established rodent fistula models (Aim 2). Finally, we will test theses engineered biomaterials in a porcine ECF model to promote aseptic healing of fistulas (Aim 3). We will evaluate healing trajectories of the fistulas using clinical observation, fluoroscopy, ultrasound, micro-CT, histology, Helios mass cytometer analysis of the cellular populations and the Hyperion imaging technology to evaluate up to 37 biomarkers on slides and RNA sequencing.
摘要

项目成果

期刊论文数量(0)
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Ali Khademhosseini其他文献

Ali Khademhosseini的其他文献

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{{ truncateString('Ali Khademhosseini', 18)}}的其他基金

Drug eluting injectable biomaterials for next generation chemoembolization
用于下一代化疗栓塞的药物洗脱可注射生物材料
  • 批准号:
    10397659
  • 财政年份:
    2021
  • 资助金额:
    $ 59.16万
  • 项目类别:
Drug eluting injectable biomaterials for next generation chemoembolization
用于下一代化疗栓塞的药物洗脱可注射生物材料
  • 批准号:
    10620134
  • 财政年份:
    2021
  • 资助金额:
    $ 59.16万
  • 项目类别:
Drug eluting injectable biomaterials for next generation chemoembolization
用于下一代化疗栓塞的药物洗脱可注射生物材料
  • 批准号:
    10230909
  • 财政年份:
    2021
  • 资助金额:
    $ 59.16万
  • 项目类别:
Healing enterocutaneous fistulas using bioengineered biomaterials
使用生物工程生物材料治愈肠皮瘘
  • 批准号:
    10532787
  • 财政年份:
    2021
  • 资助金额:
    $ 59.16万
  • 项目类别:
Treatment of arterial aneurysms using an injectable biomaterial
使用可注射生物材料治疗动脉瘤
  • 批准号:
    10171610
  • 财政年份:
    2018
  • 资助金额:
    $ 59.16万
  • 项目类别:
Treatment of arterial aneurysms using an injectable biomaterial
使用可注射生物材料治疗动脉瘤
  • 批准号:
    9883832
  • 财政年份:
    2018
  • 资助金额:
    $ 59.16万
  • 项目类别:
Engineering personalized micro-tumor ecosystems
设计个性化微肿瘤生态系统
  • 批准号:
    10261573
  • 财政年份:
    2017
  • 资助金额:
    $ 59.16万
  • 项目类别:
Engineering personalized micro-tumor ecosystems
设计个性化微肿瘤生态系统
  • 批准号:
    9756346
  • 财政年份:
    2017
  • 资助金额:
    $ 59.16万
  • 项目类别:
Targeted chemotherapy delivery and capture
靶向化疗递送和捕获
  • 批准号:
    9913518
  • 财政年份:
    2017
  • 资助金额:
    $ 59.16万
  • 项目类别:
Targeted chemotherapy delivery and capture
靶向化疗递送和捕获
  • 批准号:
    9333647
  • 财政年份:
    2017
  • 资助金额:
    $ 59.16万
  • 项目类别:

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