Wearable multifunctional optical device for early detection of postpartum hemorrhage

用于早期检测产后出血的可穿戴多功能光学装置

• 批准号: 10385828
• 负责人: CHRISTINE M O'BRIEN
• 金额: $ 12.77万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-06 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10385828
• 关键词: Affect; Birth; Blood; Blood Cells; Blood Pressure; Blood Vessels; Blood Volume; Blood flow; Blood specimen; Cesarean section; Cessation of life; Complement; Data; Developed Countries; Development; Devices; Diagnosis; Diagnostic; Early Diagnosis; Early treatment; England; Enrollment; Ensure; Excision; Family suidae; Financial compensation; Goals; Health Technology; Heart Rate; Hematocrit procedure; Hemoglobin; Hemoglobin concentration result; Hemorrhage; Hour; Income; Intercellular Fluid; Intervention; Knowledge; Label; Laboratories; Laser Speckle Imaging; Lasers; Light; Logistic Regressions; Maternal Health; Maternal Mortality; Measurement; Measures; Mentors; Methods; Modeling; Monitor; Operative Surgical Procedures; Optics; Organ; Outcome; Outcome Measure; Pathway interactions; Patients; Perfusion; Peripheral; Pharmacological Treatment; Phase; Physiological; Physiology; Postpartum Hemorrhage; Postpartum Period; Research; Research Personnel; Resource-limited setting; Risk; Running; Saline; Schedule; Signal Transduction; Spectrum Analysis; System; Techniques; Technology; Testing; Time; Training; Transfusion; Translating; United States; Validation; Visual; Water; Women' s Health; base; design; experimental study; high risk; improved; in vivo; indexing; innovation; maternal morbidity; novel; optical sensor; peripheral blood; porcine model; portability; pregnant; prevent; response; sensor; success; tissue oxygenation; tool; wearable sensor technology

Project Summary In this K99/R00 Pathway to Independence application, Dr. Christine O’Brien proposes detailed training in optoelectronics and postpartum hemorrhage physiology that will strategically complement her expertise in the development of optical diagnostics for women’s health. The training plan is paired with scientific studies that will develop and utilize a novel multifunctional optical device for early detection of postpartum hemorrhage in pregnant patients. The primary goal of Dr. O’Brien is to become an independent researcher in women’s health technologies. The rigorous training described and the outstanding team of mentors in wearable optical devices (Drs. Achilefu and Culver) and translational maternal health research (Drs. England and Stout) will ensure her success in reaching this ambitious goal. Through her training plan, Dr. O’Brien will gain 1) expertise in development of small, portable optoelectronic devices; 2) strengthened knowledge of postpartum hemorrhage physiology and research; and 3) knowledge of strategies and best practices for running a successful and innovative independent lab. Postpartum hemorrhage (PPH), defined as the loss of 1 L of blood or more within 24 hours after birth, is the leading cause of maternal mortality worldwide. Importantly, PPH is the most preventable cause of maternal mortality, and the leading factors causing preventable PPH are delay in diagnosis and treatment. Thus, there is an urgent need for an early and accurate alert system that can facilitate prompt treatment to prevent PPH-related mo. During hemorrhage, the body tries to compensate for blood loss by shunting blood from the periphery to vital organs and replenishing reduced blood volume with water from the interstitium. These compensation mechanisms help stabilize the patient, delaying the time until global vascular indicators such as blood pressure and heart rate are affected, the current measurements used to predict PPH. Thus, monitoring of peripheral blood flow and blood content can yield early indicators of hemorrhage. Optical technologies are well suited to noninvasively measure blood flow and blood content. Preliminary experiments run by the candidate demonstrated sensitivity to reduced perfusion in vivo and measured significant differences between blood samples diluted to physiologic levels seen during PPH using complimentary optical approaches. Based on this preliminary data, she hypothesizes that early changes in peripheral blood flow and water transfer from interstitium to the vasculature will be detected using wearable optical techniques, and such changes can detect early stages of PPH. The applicant proposes to develop a multifunctional wearable optical device to measure these early responses towards the development of an early warning system for improved PPH management.

项目摘要 在此K99/R 00独立之路应用程序中，克莉丝汀奥布莱恩博士提出了详细的培训 在光电子学和产后出血生理学，这将战略性地补充她的专业知识， 发展用于妇女健康的光学诊断。培训计划与科学研究相结合， 开发和利用一种新型的多功能光学装置，用于早期发现产后出血， 怀孕的病人奥布莱恩博士的主要目标是成为一名独立的妇女问题研究人员。 卫生技术。严格的培训描述和优秀的导师团队在可穿戴光学 设备（Drs. Mesefu和Culver）和转化孕产妇健康研究（Drs. England和Stout）将 确保她成功实现这一宏伟目标。通过她的培训计划，奥布莱恩博士将获得专业知识 2）加强对产后出血的认识 生理学和研究;和3）战略和最佳实践的知识，为运行一个成功的， 创新的独立实验室 产后出血（PPH）定义为出生后24小时内失血1 L或更多， 全球产妇死亡的主要原因。重要的是，PPH是孕产妇死亡最可预防的原因 死亡率高，导致可预防PPH的主要因素是诊断和治疗的延误。由此可见，有 迫切需要一个早期和准确的警报系统，可以促进及时治疗，以防止PPH相关 密苏里州在出血过程中，身体试图通过将血液从外周分流到 重要的器官和补充减少的血容量与水从黄芪。这些补偿 机制有助于稳定患者，延迟时间，直到全球血管指标，如血压 和心率受到影响，目前的测量用于预测PPH。因此，监测外周血 流量和血液含量可以产生出血的早期指标。光学技术非常适合于 非侵入性地测量血流量和血液含量。候选人进行的初步实验 证明了对体内灌注减少的敏感性，并测量了血液之间的显著差异。 在PPH期间使用互补光学方法观察到稀释至生理水平的样本。基于此 根据初步数据，她假设外周血流量和水转移的早期变化， 将使用可穿戴光学技术来检测脉管系统的氚，并且这种变化可以检测到 PPH的早期阶段本申请人提出开发一种多功能可穿戴光学装置， 这些早期反应，以发展一个早期预警系统，改善PPH管理。