Wearable multifunctional optical device for early detection of postpartum hemorrhage

项目摘要 在这份K99/R00独立之路申请中，克里斯汀·奥布莱恩博士建议进行详细的培训 在光电子学和产后出血生理学方面，这将战略性地补充她在 妇女健康光学诊断技术的发展。培训计划与科学研究相结合，将 一种用于产后出血早期检测的多功能光学装置的研制与应用 怀孕的病人。奥布莱恩博士的首要目标是成为妇女健康领域的独立研究员。 健康技术。所述的严格培训和可穿戴光学领域的杰出导师团队 设备(阿奇勒福博士和卡尔弗博士)和转化性孕产妇健康研究(英格兰博士和斯托特博士)将 确保她成功实现这一雄心勃勃的目标。通过她的培训计划，奥布莱恩博士将获得专业知识 开发小型便携式光电设备；2)加强对产后出血的认识 生理学和研究；以及3)战略和最佳实践的知识，以运行成功和 创新的独立实验室。 产后出血(PPH)，定义为出生后24小时内失血1 L或以上。 这是全球孕产妇死亡的主要原因。重要的是，产后出血是母体疾病最可预防的原因 死亡率，导致可预防的产后出血的主要因素是延误诊断和治疗。因此，有 迫切需要一种早期和准确的警报系统，以促进及时治疗，以预防PPH相关 莫。在出血期间，身体试图通过将血液从外周分流到 重要器官和补充减少血液容量的间质中的水。这些补偿 机制有助于稳定患者，延迟时间，直到全球血管指标，如血压 和心率受到影响，目前用于预测PPH的测量方法。因此，对外周血液的监测 血流量和血液含量可以作为出血的早期指标。光学技术非常适合于 无创测量血流量和血液含量。候选人进行的初步实验 表现出对体内血流灌注量减少的敏感性，并测量到血液和 使用免费光学方法将样品稀释到PPH过程中看到的生理水平。在此基础上 初步数据，她假设早期外周血流量和水转移的变化 血管系统的间质将使用可穿戴光学技术进行检测，这种变化可以检测到 产后出血早期。申请人提出开发一种多功能可穿戴光学设备来测量 这些早期反应是为了建立一个改善PPH管理的早期预警系统。

Project Summary In this K99/R00 Pathway to Independence application, Dr. Christine O’Brien proposes detailed training in optoelectronics and postpartum hemorrhage physiology that will strategically complement her expertise in the development of optical diagnostics for women’s health. The training plan is paired with scientific studies that will develop and utilize a novel multifunctional optical device for early detection of postpartum hemorrhage in pregnant patients. The primary goal of Dr. O’Brien is to become an independent researcher in women’s health technologies. The rigorous training described and the outstanding team of mentors in wearable optical devices (Drs. Achilefu and Culver) and translational maternal health research (Drs. England and Stout) will ensure her success in reaching this ambitious goal. Through her training plan, Dr. O’Brien will gain 1) expertise in development of small, portable optoelectronic devices; 2) strengthened knowledge of postpartum hemorrhage physiology and research; and 3) knowledge of strategies and best practices for running a successful and innovative independent lab. Postpartum hemorrhage (PPH), defined as the loss of 1 L of blood or more within 24 hours after birth, is the leading cause of maternal mortality worldwide. Importantly, PPH is the most preventable cause of maternal mortality, and the leading factors causing preventable PPH are delay in diagnosis and treatment. Thus, there is an urgent need for an early and accurate alert system that can facilitate prompt treatment to prevent PPH-related mo. During hemorrhage, the body tries to compensate for blood loss by shunting blood from the periphery to vital organs and replenishing reduced blood volume with water from the interstitium. These compensation mechanisms help stabilize the patient, delaying the time until global vascular indicators such as blood pressure and heart rate are affected, the current measurements used to predict PPH. Thus, monitoring of peripheral blood flow and blood content can yield early indicators of hemorrhage. Optical technologies are well suited to noninvasively measure blood flow and blood content. Preliminary experiments run by the candidate demonstrated sensitivity to reduced perfusion in vivo and measured significant differences between blood samples diluted to physiologic levels seen during PPH using complimentary optical approaches. Based on this preliminary data, she hypothesizes that early changes in peripheral blood flow and water transfer from interstitium to the vasculature will be detected using wearable optical techniques, and such changes can detect early stages of PPH. The applicant proposes to develop a multifunctional wearable optical device to measure these early responses towards the development of an early warning system for improved PPH management.