Magnetic Modulation on Targeted Neural Circuits in Autism
对自闭症目标神经回路的磁调制
基本信息
- 批准号:10385860
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:Advisory CommitteesAffectAwardBehavior assessmentBehavioralBehavioral AssayBiological AssayBrainCallithrixChemicalsChemistryChildClustered Regularly Interspaced Short Palindromic RepeatsCodeCommittee MembersCommunitiesDiagnosisElectronicsEngineeringEnsureEquilibriumEtiologyFunctional disorderFutureGenesGlutamate Metabolism PathwayGlutamatesGoalsHumanInfrastructureInstitutesInterdisciplinary StudyInterventionInvestigationKnowledgeLaboratory ResearchLeadLigandsLightLinkMagnetic nanoparticlesMagnetismMentorsMissionModelingMolecularMusMutationNanotechnologyNeuromodulatorNeuronsNeurosciencesNucleic AcidsOutcomePathologyPathway interactionsPenetrationPharmacologyPhasePhase TransitionPhenotypePopulationPrevalencePropertyProtocols documentationResearchResourcesRiskRodentScienceShapesSiteSocial BehaviorSocial InteractionSourceSpecificityStructureSupervisionSurfaceSynapsesSystemTechniquesTechnologyTestingTherapeuticTrainingTransgenic MiceViralWild Type MouseWorkautism spectrum disorderawakebehavior observationbehavior testbehavioral outcomebehavioral phenotypingbehavioral studybrain researchcareercell typechemical synthesisdesigneffective therapyempoweredexperienceflexibilitygene therapygenetic manipulationimplantationimprovedliposome vectormagnetic fieldminimally invasivemouse modelnanocarriernervous system disorderneural circuitneurobehavioralneurobehavioral testneuromechanismneurophysiologyneuroregulationnon-viral gene deliverynonhuman primateoptogeneticspost-doctoral trainingprofessorprogramsreceptorrelating to nervous systemremote controlscientific atmosphereside effectskillssocialsocial deficitstheranosticstooltranslation to humanswireless
项目摘要
Project Summary and Abstract
My overall career goal is to establish an independent research program focused on leveraging cutting-edge
technologies of materials engineering, genetic manipulation and neurobehavioral science to study neural circuits
underlying autism spectrum disorders (ASDs). I hypothesize that a remotely controlled magnetic
neuromodulation tool will link precise circuit-level neural modulation to behavioral outcomes, and thus empower
neural circuitry interrogation with systems neuroscience. To realize this goal, I have received training in extensive
research fields including materials engineering, nanotechnology, cellular neurophysiology, and neuroscience.
With this award, in my future career I will open up a new interdisciplinary research pathway of developing
remotely controlled magnetic tools that enable pharmacological and gene-editing intervention on specific neural
circuits along with the behavioral assessment on freely moving mice and awake, untethered non-human primates
(NHPs). In the mentored phase, I will work under the supervision of Professor Polina Anikeeva - an expert in
optoelectronic and magnetic neural interfaces, with the guidance of my advisory committee consisting of
Professors Guoping Feng, Feng Zhang, Mriganka Sur, and Zhigang He. With their strong supports, I will receive
additional training in gene editing, social behavioral test design and experimental experience with autism models
of mice and marmosets, which will equip me with the knowledge and skills necessary to further the study of
neural underpinnings of ASDs and launch my independent career. The work in mentored phase will be done at
the Research Laboratory of Electronics and the McGovern Institute for Brain Research at MIT, which offer an
active multidisciplinary research atmosphere, expansive infrastructural resources and a valuable intellectual
community necessary for the implementation of the proposed project. During my Simons postdoctoral training at
MIT, I established a chemomagnetic technique to pharmacologically modulate identifiable neural populations
with behavioral assessment in freely moving mice. Hence, my immediate goal is to advance this technique into
a multiplexed toolkit that enables multiple-site bidirectional control of circuit-level neural modulation. In Aim 1, I
will improve the chemical synthesis of magnetic nanoparticles (MNPs) and liposomal nanocarriers to enable
multiplexing control with paired ligand-receptors under disparate magnetic field conditions and implement the
multiple-site neural modulation of brain structures that coordinate social behaviors. Next (Aim 2), I will advance
this magnetic technique with gene editing approaches to enable non-viral gene delivery to cell-type specific
neural circuits relevant to social processing. In the independent phase (Aim 3), I will validate the magnetic
modulation on the targeted neural circuits to ameliorate social behavior deficits in transgenic mice, e.g. Shank3-
/-. With the advanced magnetic electronics apparatuses, I will further adapt this technique to social interaction
assessment in marmosets and introduce a potential magnetic field-assisted theranostic platform for ASDs.
项目摘要及摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Siyuan Rao其他文献
Siyuan Rao的其他文献
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{{ truncateString('Siyuan Rao', 18)}}的其他基金
Magnetic Modulation on Targeted Neural Circuits in Autism
对自闭症目标神经回路的磁调制
- 批准号:
10598502 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Magnetic Modulation on Targeted Neural Circuits in Autism
对自闭症目标神经回路的磁调制
- 批准号:
10321715 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Magnetic Modulation on Targeted Neural Circuits in Autism
对自闭症目标神经回路的磁调制
- 批准号:
9805249 - 财政年份:2019
- 资助金额:
$ 24.9万 - 项目类别:
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