Using natural language processing and machine learning to identify potentially preventable hospital admissions among outpatients with chronic lung diseases

使用自然语言处理和机器学习来识别慢性肺病门诊患者可能可预防的住院情况

• 批准号: 10383738
• 负责人: Gary Weissman
• 金额: $ 17.38万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-09 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10383738
• 关键词: Accounting; Acute; Address; Adherence; Admission activity; Adult; Ambulatory Care; Attention; Automobile Driving; Bioinformatics; Caregivers; Caring; Characteristics; Chronic Obstructive Pulmonary Disease; Chronic lung disease; Classification; Clinical; Communities; Data; Data Set; Data Sources; Diagnosis; Discrimination; Disease; Early Intervention; Early identification; Education; Electronic Health Record; Ensure; Future; Goals; Health Policy; Health system; Home; Hospital Costs; Hospitalization; Hospitals; Inpatients; Interstitial Lung Diseases; Intervention; Interview; K-Series Research Career Programs; Machine Learning; Master of Science; Measures; Mentors; Mentorship; Methodology; Methods; Modeling; Monitor; National Heart, Lung, and Blood Institute; Natural Language Processing; Nature; Nurses; Outpatients; Palliative Care; Patient Care; Patient Preferences; Patients; Pennsylvania; Performance; Persons; Phenotype; Physicians; Policy Research; Population; Positioning Attribute; Primary Health Care; Research; Research Methodology; Research Personnel; Resources; Risk; Risk Estimate; Social support; Structure; Supervision; Symptoms; Techniques; Testing; Text; Time; TimeLine; Training; United States; Universities; Validation; Work; administrative database; base; career; career development; clinical center; clinical encounter; computer science; cost; design; discrete data; end of life; experience; hospital readmission; improved; innovation; instrument; interest; model development; modifiable risk; novel; predictive modeling; preference; prevent; preventive intervention; psychiatric comorbidity; randomized trial; response; risk prediction model; skills; social; statistical learning; structured data; supportive environment; trend; trial design; unstructured data

Project Summary Patients living with chronic lung diseases (CLDs) are frequently admitted to the hospital for potentially preventable causes. Such admissions may be discordant with patient preferences and/or represent a low-value allocation of health system resources. To anticipate such admissions, existing clinical prediction models in this field typically produce an “all-cause” risk estimate which, even if accurate, overlooks the actionable mechanisms behind admission risk and therefore fails to identify a prescribed response. This limitation may explain the only modest – at best – reductions in hospital admissions and readmissions seen in most intervention bundles that have been tested in this population. An opportunity exists, therefore, to predict hospitalization risk while simultaneously identifying patient phenotypes (i.e. some constellation of social, demographic, clinical, and other characteristics) for which known preventive interventions exist. The proposed study seeks to overcome these limitations and capitalize on this opportunity by (1) conducting semi-structured interviews with hospitalized patients with CLDs, and their caregivers and clinicians, to directly identify modifiable risks and their associated phenotypes driving hospital admissions; (2) using natural language processing techniques (NLP) to build classification models that will leverage nuanced narrative, social, and clinical information in the unstructured text of clinical encounter notes to identify patients with these phenotypes; and (3) building risk prediction model focused on actionable phenotypes with a wide-array of traditional regression and machine learning approaches while also incorporating large numbers of predictor variables from text data and accounting for time-varying trends. The candidate's preliminary work using basic NLP techniques to significantly improve the discrimination of clinical prediction models in an inpatient population has motivated this methodologic approach. The rising burden and costs of hospitalizations associated with CLDs, and the increasing attention from federal payers, highlights the critical nature of this work. Completion of this research will build upon the candidate's past training, which includes a Masters of Science in Health Policy Research obtained with NHLBI T32 support, and will provide the experience, education, and mentorship to allow the candidate to become a fully independent investigator. Based on the candidate's tailored training plan, he will acquire advanced skills in mixed-methods research, NLP, and trial design all through coursework, close mentoring and supervision, and direct practice. The skills will position him ideally to submit successful R01s testing the deployment of the proposed clinical prediction models in real-world settings. The candidate's primary mentor, collaborators, and advisors will ensure adherence to the proposed timeline and goals and provide a supportive environment for him to develop an independent research career testing the real-world deployment of clinical prediction models to reduce low-value and preference-discordant care for patients with CLDs.

项目总结

项目成果

Hierarchical Condition Categories for Pulmonary Diseases: Population Health Management and Policy Opportunities.

肺部疾病的分级病症类别：人口健康管理和政策机会。

• DOI: 10.1016/j.chest.2018.12.013
• 发表时间: 2019
• 期刊: Chest
• 影响因子: 9.6
• 作者: Weissman,GaryE

A vignette-based evaluation of ChatGPT's ability to provide appropriate and equitable medical advice across care contexts.

• DOI: 10.1038/s41598-023-45223-y
• 发表时间: 2023-10-19
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Nastasi, Anthony J.;Courtright, Katherine R.;Halpern, Scott D.;Weissman, Gary E.
• 通讯作者: Weissman, Gary E.

Word embeddings trained on published case reports are lightweight, effective for clinical tasks, and free of protected health information.

• DOI: 10.1016/j.jbi.2021.103971
• 发表时间: 2022-01
• 期刊: Journal of biomedical informatics
• 影响因子: 4.5
• 作者: Flamholz ZN;Crane-Droesch A;Ungar LH;Weissman GE
• 通讯作者: Weissman GE