Validation and Expansion of Established Norms for Measures of Tinnitus Perception

我们之前的工作收集了耳鸣知觉和耳鸣功能测量的标准数据 效果(反应)。患有慢性耳鸣的参与者，没有接受针对耳鸣的干预， 分别于0、1、3、6个月进行耳鸣心理声学测量和耳鸣问卷调查。参与者 包括六个年龄范围(18-30岁；31-40岁；41-50岁；51-60岁；61-70岁；70岁以上)。这些数据将有助于 所有数据分析完成后，不同测量的特定年龄参考值(最终参与者 测试发生在2018年10月30日)。拟议的研究将通过以下方式扩大这项工作：(1)建立 通过测试一批新参与者，对规范标准数据库进行评估；(2)评估长期 通过从参与者那里获得额外的纵向数据来评估耳鸣心理声学测量的重复性 回顾以前的研究；(3)开发评估个人音调感知能力的方法和 根据需要提供培训；(4)评估音高训练对耳鸣音调匹配能力的影响 提高精确度；及。(5)继续发展以药片为基础的耳鸣评估系统。 通过改进界面和其他性能功能，以及通过创建快速评估 程序，以在10分钟内获得可靠的响度匹配和音调匹配。要实现这些目标 目标，新参与者将被登记到两个不同的队列中，分别为150人和100人(总共新的 招生人数n=250人)。这两组新参与者都将符合与 先前的研究。150名新参与者将在基线以及1、3和6个月时接受重复测试 重复上一次研究中所做的测试。另外100名新参与者将是 注册参加音高匹配培训计划的评估。在这些人中，有一半将完成一项计划- 将在基线测试开始之前进行的感知测试和培训(比较 训练组与未训练组之间的音调匹配数据将决定计划是否在以下方面有所改善- 音调匹配测试的会话可靠性)。最后，前一项研究的第三批100名参与者 将在基线测试后约3年重新进行重复测试，以获得长期可靠性数据。在……里面 除数据收集外，还将继续努力完成平板电脑的开发和验证 TES，意在为该系统临床应用做好准备。需要5-10分钟的测试协议是 为了使TES有可能在退伍军人管理局听力学专家中得到更广泛的使用，TES是必要的。一场快速的TES 将与部分参与者一起开发、测试和验证协议，以实现这一目标。 完成本申请中描述的工作将实现许多目标，包括使耳鸣 心理声学测量对临床和研究应用更有用和实用。

Our previous work has collected normative data for measures of both tinnitus perception and tinnitus functional effects (reactions). Participants with chronic tinnitus, who were not receiving tinnitus-specific intervention, completed tinnitus psychoacoustic measures and tinnitus questionnaires at 0, 1, 3, and 6 months. Participants were included in each of six age ranges (18-30; 31-40; 41-50; 51-60; 61-70; 70+). These data will contribute to age-specific reference values for the different measures once all data analyses are complete (final participant testing occurred on October 30, 2018). The proposed study will extend and expand this effort by: (1) building on the normative standards database by testing a cohort of new participants; (2) assessing long-term repeatability of tinnitus psychoacoustic measures by obtaining additional longitudinal data from participants recalled from the previous study; (3) developing methodology to evaluate individual pitch-perception ability and providing training as needed; (4) evaluating the effect of pitch training on ability to match tinnitus pitch with greater precision; and (5) continuing development of the tablet-based tinnitus evaluation system (TES) for clinical utility by improving the interface and other performance features, and by creating a rapid assessment program to obtain reliable loudness matches and pitch matches in under 10 minutes. To accomplish these objectives, new participants will be enrolled into two separate cohorts of 150 and 100 individuals (total new enrollment n=250). Both cohorts of new participants will meet the same inclusion criteria as used in the previous study. The 150 new participants will undergo repeated testing at baseline and at 1, 3, and 6 months to replicate testing as done during the previous study. The separate cohort of 100 new participants will be enrolled to evaluate a training program for pitch matching. Of these, half will complete a program of pitch- perception testing and training that will be administered prior to the start of baseline testing (comparison of pitch matching data between groups with vs. without training will determine if the program improves within- session reliability of the pitch matching test). Finally, a third cohort of 100 of the previous study's participants will return to repeat testing ~3 years following their baseline testing to obtain long-term reliability data. In addition to data collection, efforts will be ongoing to complete development and validation of the tablet-based TES with the intent to ready this system for clinical application. A test protocol requiring 5-10 minutes is needed for the TES to have the potential to achieve more widespread use among VA audiologists. A rapid TES protocol will be developed, tested, and validated with a subset of participants to achieve this objective. Completing the work described in this application will accomplish many objectives, including making tinnitus psychoacoustic measures more useful and practical for clinical and research utilization.