Validation and Expansion of Established Norms for Measures of Tinnitus Perception

我们以前的工作已经收集了耳鸣感知和耳鸣功能测量的标准数据 反应（Reaction）。患有慢性耳鸣的参与者，没有接受耳鸣特异性干预， 在0、1、3和6个月时完成耳鸣心理声学测量和耳鸣问卷调查。参与者 包括六个年龄范围（18 - 30; 31 - 40; 41 - 50; 51 - 60; 61 - 70; 70+）中的每一个。这些数据将有助于 完成所有数据分析后，不同测量的年龄特定参考值（最终参与者 测试于2018年10月30日进行）。拟议的研究将通过以下方式扩展和扩大这一努力：（1）建立 通过测试一批新参与者，对规范标准数据库进行评估;（2）评估长期 通过从参与者获得额外的纵向数据进行耳鸣心理声学测量的可重复性 （3）发展评价个体音高知觉能力的方法， 根据需要提供训练;（4）评估音调训练对耳鸣音调匹配能力的影响， 更高的精度;和（5）继续开发基于平板电脑的耳鸣评估系统（TES）， 通过改进界面和其他性能特征，并通过创建快速评估， 程序获得可靠的响度匹配和音高匹配在10分钟内。完成这些 目标，新参与者将被招募到两个单独的队列中，每个队列150人和100人（新参与者总数 入组n = 250）。两组新受试者将符合与研究中使用的相同的入选标准。 以前的研究。150名新参与者将在基线和1、3、6个月时接受重复测试， 重复试验，如先前研究中所做。另外100名新参与者将 注册来评估音高匹配的训练计划。其中，一半将完成一个音高计划- 将在基线测试开始前进行的感知测试和培训（比较 有训练和没有训练的组之间的音高匹配数据将决定该程序是否在- 音调匹配测试的会话可靠性）。最后，第三组100名先前研究的参与者 将在基线测试后约3年返回重复测试，以获得长期可靠性数据。在 除了数据收集，还将继续努力完成基于平板电脑的 TES旨在为该系统的临床应用做好准备。需要5 - 10分钟的测试方案是 所需的TES有可能实现更广泛的使用之间的VA听力学家。快速TES 将与一部分参与者一起制定、测试和验证方案，以实现这一目标。 完成本申请中描述的工作将实现许多目标，包括使耳鸣 心理声学测量更有用和实用的临床和研究利用。

Our previous work has collected normative data for measures of both tinnitus perception and tinnitus functional effects (reactions). Participants with chronic tinnitus, who were not receiving tinnitus-specific intervention, completed tinnitus psychoacoustic measures and tinnitus questionnaires at 0, 1, 3, and 6 months. Participants were included in each of six age ranges (18-30; 31-40; 41-50; 51-60; 61-70; 70+). These data will contribute to age-specific reference values for the different measures once all data analyses are complete (final participant testing occurred on October 30, 2018). The proposed study will extend and expand this effort by: (1) building on the normative standards database by testing a cohort of new participants; (2) assessing long-term repeatability of tinnitus psychoacoustic measures by obtaining additional longitudinal data from participants recalled from the previous study; (3) developing methodology to evaluate individual pitch-perception ability and providing training as needed; (4) evaluating the effect of pitch training on ability to match tinnitus pitch with greater precision; and (5) continuing development of the tablet-based tinnitus evaluation system (TES) for clinical utility by improving the interface and other performance features, and by creating a rapid assessment program to obtain reliable loudness matches and pitch matches in under 10 minutes. To accomplish these objectives, new participants will be enrolled into two separate cohorts of 150 and 100 individuals (total new enrollment n=250). Both cohorts of new participants will meet the same inclusion criteria as used in the previous study. The 150 new participants will undergo repeated testing at baseline and at 1, 3, and 6 months to replicate testing as done during the previous study. The separate cohort of 100 new participants will be enrolled to evaluate a training program for pitch matching. Of these, half will complete a program of pitch- perception testing and training that will be administered prior to the start of baseline testing (comparison of pitch matching data between groups with vs. without training will determine if the program improves within- session reliability of the pitch matching test). Finally, a third cohort of 100 of the previous study's participants will return to repeat testing ~3 years following their baseline testing to obtain long-term reliability data. In addition to data collection, efforts will be ongoing to complete development and validation of the tablet-based TES with the intent to ready this system for clinical application. A test protocol requiring 5-10 minutes is needed for the TES to have the potential to achieve more widespread use among VA audiologists. A rapid TES protocol will be developed, tested, and validated with a subset of participants to achieve this objective. Completing the work described in this application will accomplish many objectives, including making tinnitus psychoacoustic measures more useful and practical for clinical and research utilization.