New Cooperative Catalysis Concepts for Asymmetric Synthesis

不对称合成的新协同催化概念

基本信息

批准号：
10387927
负责人：
Karl A Scheidt
金额：
$ 8.91万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-05-31
项目状态：
未结题

项目摘要

Project Summary Advances in 21st century medicine have greatly impacted society, but a serious need persists for new therapeutics that either exploit known biological processes or possess novel mechanisms of action. The development of new, selective, and enabling chemical methodology to drive the rapid investigation of the reactivity and biological activity of natural products and related probes is vital to understanding their mechanism of action and developing new therapeutics for the treatment and/or prevention of disease. A primary goal of our research program is to discover and develop new cooperative catalytic, stereoselective transformations that facilitate the highly efficient construction of valuable materials. The new methods advanced in this proposal have a) significant and highly encouraging preliminary results, and b) been inspired by bioactive molecules/natural products that will subsequently facilitate the efficient construction of these targets and potential applications towards clinical endpoints. The innovative cooperative catalytic strategies we are pursuing will power investigations of biological processes relevant to the discovery of new potential therapies and strategies that generate the targeted bioactive molecules while providing broad solutions to synthesizing related families of compounds. The specific goals of this research are: a) the exploration of new, cooperative carbene catalyzed processes, b) the development of stereoselective catalytic carbocation-driven transformations, c) the investigation of Lewis acid-catalyzed -Umpolung type radical reactions, and d) the merger of photocatalytically-generated reactivity with biocatalysis. We anticipate that these research activities will fundamentally advance human health by providing innovative tactics and strategies to access many important classes of health relevant compounds.

项目摘要 21世纪医学的进步极大地影响了社会，但对新的需求仍然存在利用已知生物过程或具有新颖的作用机理的治疗剂。这开发新的，选择性和有助于化学方法论，以推动对天然产品和相关问题的反应性和生物活性对于理解其作用机理和开发新疗法以治疗和/或预防疾病。一个我们的研究计划的主要目标是发现和开发新的合作催化，立体选择性有助于高效构造有价值材料的转换。新方法该提案中的高级a）具有重大且令人鼓舞的初步结果，b）受到启发通过生物活性分子/天然产物，随后将有效地构建这些临床终点的目标和潜在应用。创新的合作催化策略我们正在追求与发现新潜力有关的生物过程的电力投资产生目标生物活性分子的疗法和策略，同时提供广泛的解决方案合成相关的化合物家族。这项研究的具体目标是：a）探索新的合作卡宾催化过程，b）立体选择性催化碳酸化驱动转化的发展，c）刘易斯的研究酸催化的-umpolung型自由基反应，d）光催化产生的反应性的合并与生物催化。我们预计这些研究活动将从根本上通过提供创新的策略和策略，以获取许多重要的健康相关化合物类别。