New Cooperative Catalysis Concepts for Asymmetric Synthesis

项目摘要 21世纪医学的进步极大地影响了社会，但对新医学的迫切需求依然存在 利用已知的生物过程或拥有新的作用机制的治疗学。这个 开发新的、选择性的和使能的化学方法来推动对 天然产物和相关探针的反应性和生物活性对于理解它们的 作用机制和开发治疗和/或预防疾病的新疗法。一个 我们的研究计划的主要目标是发现和开发新的合作催化，立体选择性 促进有价值的材料的高效建造的转变。新方法 本提案的进展情况a)取得了重要的、非常令人鼓舞的初步成果，b)受到了启发 通过生物活性分子/天然产物，随后将促进这些 临床终点的目标和潜在应用。创新的合作催化策略WE 正在致力于对与发现新潜力相关的生物过程进行调查 产生靶向生物活性分子的疗法和策略，同时提供广泛的解决方案 合成相关化合物家族。 这项研究的具体目标是：a)探索新的、合作的卡宾催化过程，b) 立体选择性催化碳正离子驱动转化的进展，c)Lewis的研究 酸催化的-Umpolung类型的自由基反应，以及d)光催化产生的反应性的合并 生物催化法。我们预计，这些研究活动将从根本上促进人类健康， 提供创新的战术和战略，以获取许多重要类别的与健康相关的化合物。

Project Summary Advances in 21st century medicine have greatly impacted society, but a serious need persists for new therapeutics that either exploit known biological processes or possess novel mechanisms of action. The development of new, selective, and enabling chemical methodology to drive the rapid investigation of the reactivity and biological activity of natural products and related probes is vital to understanding their mechanism of action and developing new therapeutics for the treatment and/or prevention of disease. A primary goal of our research program is to discover and develop new cooperative catalytic, stereoselective transformations that facilitate the highly efficient construction of valuable materials. The new methods advanced in this proposal have a) significant and highly encouraging preliminary results, and b) been inspired by bioactive molecules/natural products that will subsequently facilitate the efficient construction of these targets and potential applications towards clinical endpoints. The innovative cooperative catalytic strategies we are pursuing will power investigations of biological processes relevant to the discovery of new potential therapies and strategies that generate the targeted bioactive molecules while providing broad solutions to synthesizing related families of compounds. The specific goals of this research are: a) the exploration of new, cooperative carbene catalyzed processes, b) the development of stereoselective catalytic carbocation-driven transformations, c) the investigation of Lewis acid-catalyzed -Umpolung type radical reactions, and d) the merger of photocatalytically-generated reactivity with biocatalysis. We anticipate that these research activities will fundamentally advance human health by providing innovative tactics and strategies to access many important classes of health relevant compounds.