New Cooperative Catalysis Concepts for Asymmetric Synthesis

项目概要 21 世纪医学的进步对社会产生了巨大影响，但仍然迫切需要新的药物 利用已知生物过程或具有新颖作用机制的疗法。的 开发新的、选择性的、有利的化学方法来推动快速研究 天然产物和相关探针的反应性和生物活性对于理解它们至关重要 作用机制并开发治疗和/或预防疾病的新疗法。一个 我们研究计划的主要目标是发现和开发新的合作催化、立体选择性 促进有价值材料高效构建的转变。新方法 该提案取得了以下进展：a) 取得了重大且非常令人鼓舞的初步成果，b) 受到了启发 通过生物活性分子/天然产物，随后将促进这些的有效构建 临床终点的目标和潜在应用。我们的创新合作催化策略 正在追求与发现新潜力相关的生物过程的意志力研究 产生靶向生物活性分子的疗法和策略，同时提供广泛的解决方案 合成相关的化合物家族。 这项研究的具体目标是：a）探索新的合作卡宾催化过程，b） 立体选择性催化碳正离子驱动转化的发展，c) Lewis 的研究 酸催化的 -Umpolung 型自由基反应，以及 d) 光催化反应性的合并 与生物催化。我们预计这些研究活动将从根本上促进人类健康 提供创新的策略和策略来获取许多重要类别的健康相关化合物。

Project Summary Advances in 21st century medicine have greatly impacted society, but a serious need persists for new therapeutics that either exploit known biological processes or possess novel mechanisms of action. The development of new, selective, and enabling chemical methodology to drive the rapid investigation of the reactivity and biological activity of natural products and related probes is vital to understanding their mechanism of action and developing new therapeutics for the treatment and/or prevention of disease. A primary goal of our research program is to discover and develop new cooperative catalytic, stereoselective transformations that facilitate the highly efficient construction of valuable materials. The new methods advanced in this proposal have a) significant and highly encouraging preliminary results, and b) been inspired by bioactive molecules/natural products that will subsequently facilitate the efficient construction of these targets and potential applications towards clinical endpoints. The innovative cooperative catalytic strategies we are pursuing will power investigations of biological processes relevant to the discovery of new potential therapies and strategies that generate the targeted bioactive molecules while providing broad solutions to synthesizing related families of compounds. The specific goals of this research are: a) the exploration of new, cooperative carbene catalyzed processes, b) the development of stereoselective catalytic carbocation-driven transformations, c) the investigation of Lewis acid-catalyzed -Umpolung type radical reactions, and d) the merger of photocatalytically-generated reactivity with biocatalysis. We anticipate that these research activities will fundamentally advance human health by providing innovative tactics and strategies to access many important classes of health relevant compounds.