Characterizing evolutionarily conserved mechanisms underlying sleep, clocks, and memory

联系PD/PI：Gerstner，Jason Robert 睡眠障碍和睡眠障碍影响着数以百万计的美国人，通常与其他现有的医疗方法一起发现 病症包括心血管疾病、慢性疼痛、糖尿病和神经疾病。为了更好地理解 睡眠障碍及其负面后果的并存，我们首先需要了解基本的睡眠功能。 目前的生物医学研究还不能充分解释睡眠功能，主题仍然是 有争议的。适应过程，如突触可塑性，学习和记忆，是敏感的睡眠损失，这是 可能为识别睡眠的生理功能提供重要线索。细胞和分子过程 对睡眠功能至关重要的神经组织也可能不限于神经元，但可能包括神经胶质细胞， 它们被认为可以调节新陈代谢、睡眠和认知功能。神经元-神经胶质细胞相互作用的变化， 特别是在与清醒时活动和能量依赖需求相关的突触周围，因此是关键 研究睡眠功能方面的网站。在这里，我们建议对系统发育不同的物种进行研究 将休息-活动周期的昼夜节律与睡眠需求的变化结合起来。我们还提供了新的途径 解决与进化上保守的细胞和分子活动潜在机制相关的可测试问题- 突触活动的依赖性变化，对睡眠敏感，对认知功能至关重要。 第6页 项目摘要/摘要

Contact PD/PI: Gerstner, Jason Robert Sleep disturbance and sleep disorders affect millions of Americans and are commonly found with other existing medical conditions including cardiovascular disease, chronic pain, diabetes, and neurological disorders. To better understand the comorbidities of sleep disturbance and their negative outcomes, we need to first understand basic sleep function. Current biomedical research has not been able to adequately explain sleep function, and the subject remains controversial. Adaptive processes, such as synaptic plasticity, learning, and memory, are sensitive to sleep loss, which may provide important clues for identifying the physiological function of sleep. Cellular and molecular processes that are critical for sleep function within nervous tissue also may not be restricted to neurons, but may include glial cells, which are known to regulate metabolism, sleep, and cognitive function. Changes in neuronal-glial interactions, particularly around synapses related to activity- and energy-dependent demands during wakefulness, are therefore key sites to investigate the functional aspects of sleep. Here, we propose studies in phylogenetically diverse species that integrate the circadian rhythm of rest-activity cycles with changes in sleep need. We also provide novel avenues for tackling testable questions related to evolutionarily conserved cellular and molecular mechanisms underlying activity- dependent changes in synaptic activity that are sensitive to sleep and are critical for cognitive function. Page 6 Project Summary/Abstract