Epithelial Cell Migration: Model selection for mechanistic model development
Epithelial Cell Migration: Model selection for mechanistic model development
批准号:
10389279
负责人:
David Bortz
金额:
$4.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-10 至 2023-05-31
关键词:
Automobile DrivingBehaviorBiologicalBiological PhenomenaBiological ProcessBiological SciencesCell Culture TechniquesCellsConsumptionDiabetic Foot UlcerDifferential EquationEpithelialEpithelial CellsFoundationsGoalsHandImpaired wound healingLiquid substanceManualsMathematicsMethodologyMigration AssayModelingMovementMulticellular ProcessOrganismPharmacotherapyReproducibilityResearchResearch Project GrantsTimebasecell motilitychronic woundcurative treatmentsdesignexperimental studyimprovedlarge datasetsmigrationmodel designmodel developmentnovel strategiesrobotic systemspatiotemporalworking groupwound healing
中文摘要
项目总结
英文摘要
Project Summary
The collective migration of cells is a central biological process for multicellular organisms.
Collective migration of epithelial sheets to close the gap during wound healing is an excellent
illustration of this phenomenon. Inappropriate migratory movements can result in impaired wound
healing, as seen in chronic wounds and diabetic foot ulcers. While substantial research has been
devoted to its study, we still lack a foundational understanding of what drives groups of cells to
move coherently as curative therapies are still not available for unhealable chronic wounds. Bortz,
Liu, and Dukic groups are working together to develop a model selection-based approach to
reveal driving mechanisms that control collective cell migration. Thus the long-term mathematical
goal is to develop and apply a computationally efficient and rigorously well-posed model selection
methodology for spatio-temporal biological phenomena modeled by differential equations.
Toward this end, we will pursue a synergistic experimental, mathematical, and statistical approach
to develop feasible candidate models, design and carry out validating experiments, and select the
best models to infer the dominant driving mechanisms. While we made a lot of progress in
developing mathematical frameworks for modeling various cell migratory behaviors, a bottleneck
for unlocking the potentials of our new approach is the limited throughput of cell migration assays
due to the manual experiment setup, which is tedious and time-consuming. Moreover, pipetting
by hand is error-prone and induces avoidable variability between experiments. ASSIST PLUS
from Integra Biosciences is designed for semi-automated liquid handling for cell culture studies
and drug treatments. Acquisition of this robotic system will enable us to conduct numerous
experiments in a more robustly and accelerate our research project.
期刊论文(9)
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DOI:
10.1137/21m1418927
发表时间:
2022
期刊:
SIAM Journal on Matrix Analysis and Applications
影响因子:
1.5
作者:
[Wentz, Jacqueline, Cameron, Jeffrey C., Bortz, David M.]
通讯作者:
Bortz, David M.
DOI:
10.1016/j.physd.2022.133406
发表时间:
2021-10
期刊:
Physica D. Nonlinear phenomena
影响因子:
--
作者:
[D. Messenger;D. Bortz]
通讯作者:
D. Messenger;D. Bortz
DOI:
10.1016/j.jcp.2021.110525
发表时间:
2021-07-14
期刊:
JOURNAL OF COMPUTATIONAL PHYSICS
影响因子:
4.1
作者:
[Messenger, Daniel A., Bortz, David M.]
通讯作者:
Bortz, David M.
DOI:
10.1137/20m1343166
发表时间:
2021-01-01
期刊:
MULTISCALE MODELING & SIMULATION
影响因子:
1.6
作者:
[Messenger, Daniel A., Bortz, David M.]
通讯作者:
Bortz, David M.
Data-driven and science-informed methods for the discovery of biomedical mechanisms and processes
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批准号:10624014
-
项目类别:
-
资助金额:$34.9万
-
财政年份:2023
-
负责人:David Bortz
-
依托单位:
Epithelial Cell Migration: Model selectionn for mechanistic model development
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批准号:9460745
-
项目类别:
-
资助金额:$38.5万
-
财政年份:2017
-
负责人:David Bortz
-
依托单位:
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