Conduct of studies to evaluate the toxic potential of aqueous film-forming foams (AFFF) in laboratory animals

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及水灭火泡沫灌胃后对大鼠的毒性研究。水成膜泡沫（afff）用于快速扑灭火灾，这在军事环境中至关重要。这个项目的数据将用于就钨金属和亚氧化物纤维对大鼠的潜在毒性作出合理的科学结论，并为目前可用的afff的选择和使用提供信息，但其他机构除外。该项目还支持DNTP的使命和目标以及其他联邦机构的风险评估活动。

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of aqueous fire-fighting foams in rats, following exposure via gavage. Aqueous film forming foams (AFFFs) are used to rapidly suppress fires, which is critical in military settings. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and inform the selection and use of currently available AFFFs but other agencies. This project also supports the mission and goals of DNTP and risk assessment activities of other federal agencies. Keywords: toxicity, aqueous fire-fighting foams, gavage