Conduct of studies to evaluate the toxic potential of aqueous film-forming foams (AFFF) in laboratory animals

进行研究以评估水成膜泡沫 (AFFF) 对实验动物的潜在毒性

• 批准号: 10388062
• 负责人: Barney Sparrow
• 金额: $ 43.49万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388062
• 关键词: Adverse effects; Chemicals; Data; Development; Ensure; Environmental Exposure; Exposure to; Fiber; Film; Fire - disasters; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; Metals; Military Personnel; Mission; National Toxicology Program; Oral; Rattus; Risk Assessment; Toxic effect; Toxicity Tests; Toxicology; Tungsten; aqueous; bioaccumulation; design; disorder prevention; fighting; male; public health research; sound

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of aqueous fire-fighting foams in rats, following exposure via gavage. Aqueous film forming foams (AFFFs) are used to rapidly suppress fires, which is critical in military settings. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and inform the selection and use of currently available AFFFs but other agencies. This project also supports the mission and goals of DNTP and risk assessment activities of other federal agencies. Keywords: toxicity, aqueous fire-fighting foams, gavage

该项目的目标是为国家毒理学计划(DNTP)危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及通过灌胃暴露后对大鼠进行含水灭火泡沫的毒性研究。水成膜泡沫用于快速灭火，这在军事环境中是至关重要的。该项目的数据将用于制定关于钨金属和次氧化物纤维对大鼠的潜在毒性的合理、科学的结论，并为目前可用的AFF的选择和使用提供信息，但其他机构。该项目还支持dNTP的任务和目标以及其他联邦机构的风险评估活动。 关键词：毒性、水性灭火泡沫、灌胃