Facility and Building System Upgrades Support for the Mason Biomedical Research Laboratory

为梅森生物医学研究实验室提供设施和建筑系统升级支持

• 批准号: 10394528
• 负责人: Farhang Alem
• 金额: $ 333万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394528
• 关键词: 2019-nCoV; Animals; Bacillus anthracis; Biomedical Research; Bioterrorism; Burkholderia pseudomallei; Communities; Eastern Equine Encephalitis Virus; Emerging Communicable Diseases; Equipment; Francisella tularensis; Funding; Goals; HIV; Human T-lymphotropic virus 1; Image; Infectious Diseases Research; Infrastructure; Laboratories; Laboratory Research; National Institute of Allergy and Infectious Disease; Positron-Emission Tomography; Recommendation; Research; Research Personnel; Resources; Rodent; System; United States; Universities; Venezuelan Equine Encephalitis Virus; Water; biodefense; biological research; fighting; nonhuman primate; operation; pandemic disease; pathogen; replacement tissue; response; success

Project Summary/Abstract In 2002, the NIAID convened a Panel on Bioterrorism and its implications for Biomedical Research to determine key priorities and short- and long-term goals for biodefense research in the United States. In response to the panel’s recommendations, the NIAID provided funding for the construction of two National Biocontainment Laboratories and 12 Regional Biocontainment Laboratories (RBLs). These installations have been an important resource for the nation as facilities where cutting edge scientific research on emerging infectious diseases and biodefense pathogens can be safely carried out. The Biological Research Laboratory (BRL) at George Mason University (GMU) is one of the 12 RBLs, and went into operation in July of 2010. In the decade since it opened its doors, GMU investigators have used the BRL to study select agents, such as Francisella tularensis, Burkholderia pseudomallei, Yesrinia pestis, Bacillus anthracis, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus and SARS-CoV-2, as well as other pathogens, including, HIV and HTLV-1. To continue building on the success of the BRL, we are looking to upgrade aspects of the building’s infrastructure, in addition to purchasing new caging and state-of-the-art equipment that can serve the needs of the scientific community focused on infectious disease research and fighting the next pandemic. The Specific Aims of the proposal are as follows: 1) Purchase of animal caging to expand the BRL’s ability to house various species, from rodents to non-human primates; 2) Replacement of the tissue digester; 3) Purchase of imaging equipment, including the Fuji Vevo and Mediso PET-CT; 4) Installation of an automated watering system for the animal holding rooms; 5) Replacement of hot water heaters.

项目总结/摘要 2002年，NIAID召集了一个关于生物恐怖主义及其对生物医学研究的影响的小组， 美国生物防御研究的关键优先事项和短期和长期目标。响应于 根据专家组的建议，NIAID为建造两个国家生物防护设施提供了资金， 实验室和12个区域生物防护实验室（RBL）。这些设施是一个重要的 作为国家资源的设施，对新兴传染病进行尖端科学研究， 生物防御病原体可以安全地进行。 乔治梅森大学（GMU）的生物研究实验室（BRL）是12个RBL之一， 于2010年7月投入运营。在它开放以来的十年里，GMU调查人员利用BRL， 研究选择因子，例如土拉热弗朗西丝氏菌、类鼻疽伯克霍尔德氏菌、鼠疫耶尔森氏菌、芽孢杆菌 炭疽病、委内瑞拉马脑炎病毒、东部马脑炎病毒和SARS-CoV-2，以及 其他病原体，包括HIV和HTLV-1。 为了继续在BRL的成功基础上再接再厉，我们希望升级大楼的基础设施， 除了购买新的笼子和最先进的设备，可以服务于科学的需要， 社区专注于传染病研究和对抗下一次大流行。 该提案的具体目的如下：1）购买动物笼，以扩大BRL的能力， 容纳各种物种，从啮齿动物到非人类灵长类动物; 2）更换组织消化器; 3）购买 成像设备，包括Fuji Vevo和Mediso PET-CT; 4）安装自动供水系统 动物饲养室的系统; 5）更换热水器。