Facility and Building System Upgrades Support for the Mason Biomedical Research Laboratory

为梅森生物医学研究实验室提供设施和建筑系统升级支持

• 批准号: 10394528
• 负责人: Farhang Alem
• 金额: $ 333万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394528
• 关键词: 2019-nCoV; Animals; Bacillus anthracis; Biomedical Research; Bioterrorism; Burkholderia pseudomallei; Communities; Eastern Equine Encephalitis Virus; Emerging Communicable Diseases; Equipment; Francisella tularensis; Funding; Goals; HIV; Human T-lymphotropic virus 1; Image; Infectious Diseases Research; Infrastructure; Laboratories; Laboratory Research; National Institute of Allergy and Infectious Disease; Positron-Emission Tomography; Recommendation; Research; Research Personnel; Resources; Rodent; System; United States; Universities; Venezuelan Equine Encephalitis Virus; Water; biodefense; biological research; fighting; nonhuman primate; operation; pandemic disease; pathogen; replacement tissue; response; success

Project Summary/Abstract In 2002, the NIAID convened a Panel on Bioterrorism and its implications for Biomedical Research to determine key priorities and short- and long-term goals for biodefense research in the United States. In response to the panel’s recommendations, the NIAID provided funding for the construction of two National Biocontainment Laboratories and 12 Regional Biocontainment Laboratories (RBLs). These installations have been an important resource for the nation as facilities where cutting edge scientific research on emerging infectious diseases and biodefense pathogens can be safely carried out. The Biological Research Laboratory (BRL) at George Mason University (GMU) is one of the 12 RBLs, and went into operation in July of 2010. In the decade since it opened its doors, GMU investigators have used the BRL to study select agents, such as Francisella tularensis, Burkholderia pseudomallei, Yesrinia pestis, Bacillus anthracis, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus and SARS-CoV-2, as well as other pathogens, including, HIV and HTLV-1. To continue building on the success of the BRL, we are looking to upgrade aspects of the building’s infrastructure, in addition to purchasing new caging and state-of-the-art equipment that can serve the needs of the scientific community focused on infectious disease research and fighting the next pandemic. The Specific Aims of the proposal are as follows: 1) Purchase of animal caging to expand the BRL’s ability to house various species, from rodents to non-human primates; 2) Replacement of the tissue digester; 3) Purchase of imaging equipment, including the Fuji Vevo and Mediso PET-CT; 4) Installation of an automated watering system for the animal holding rooms; 5) Replacement of hot water heaters.

项目摘要/摘要 2002年，NIAID召集了一个关于生物恐怖主义的小组及其对生物医学研究的影响 在美国，生物陷入困境研究的主要优先事项以及短期和长期目标。回应 小组的建议，NIAID为建造两种国家生物内疗法提供了资金 实验室和12个区域生物设备实验室（RBL）。这些装置一直很重要 国家的资源是有关新兴传染病和 可以安全地执行生物性病原体。 乔治·梅森大学（GMU）的生物研究实验室（BRL）是12个RBL之一，去了 在2010年7月运营。自从开门以来的十年中，GMU调查人员已使用BRL 研究精选的药物，例如弗朗西斯氏菌，伯克霍尔德·伪虫，耶稣虫，芽孢杆菌 炭疽，委内瑞拉马脑炎病毒，东马脑炎病毒和SARS-COV-2，以及 其他病原体，包括HIV和HTLV-1。 为了继续建立BRL的成功，我们正在寻求升级建筑物基础设施的各个方面， 除了购买可以满足科学需求的新笼子和最先进的设备外 社区专注于传染病研究并与下一个大流行作斗争。 该提案的具体目的如下：1）购买动物笼以扩大BRL的能力 从啮齿动物到非人类隐私，可以容纳各种物种； 2）更换组织消化酯； 3）购买 成像设备，包括Fuji Vevo和Mediso PET-CT； 4）安装自动浇水 动物持有房间的系统； 5）更换热水器。