BSL-3 Practices Core

BSL-3练习：摘要 BSL-3实践核心是满足乔治梅森大学S生物医学的关键 研究实验室S使命对新发传染病进行开创性研究 疾病，对大流行病的防备作出有意义的贡献，并做好及时应对的准备 由传染性疾病引起的生物恐怖袭击或其他国家和全球紧急情况 病原体。BRL作为科学协作的中心，1)产生先进的 病原体生物学和宿主相互作用机制的知识，以及2)评估诊断， 治疗学和疫苗。为了完成任务，GMU必须有一个足够大小的 训练有素的劳动力，能够安全地进行高质量的工作，并符合联邦 法规；有效操作先进的仪器设备；并生成可靠的数据以支持 更快地将新发现转化为市场。 BRL拥有强大的BSL-3实践核心，以确保持续安全地进行 在符合美国国家过敏学会和美国国家过敏学会标准的高安全系数环境中进行的研究 传染病(NIAID)、疾病控制中心(CDC)和美国卫生部 农业(美国农业部)/动植物卫生检验局(APHIS)条例。 为病原体和选择制剂研究创造和维持一个合规的工作环境 对实验室操作员的健康和安全至关重要，并防止环境污染 曝光。GMU BSL-3实践的实施战略核心集中在1) 通过提供一致、个性化的课程来加强安全培训，2)实施 提高研究质量和重现性的良好实验室规范(GLP)，以及3) 确保BSL-3研究界能够有效地利用高级研究 通过BRL经验丰富的成员的支持和培训来实施工具 研究团队。

BSL-3 PRACTICES: ABSTRACT The BSL-3 Practices core is critical for meeting George Mason University (GMU)’s Biomedical Research Lab (BRL)’s mission to perform groundbreaking research on emerging infectious diseases, contribute meaningfully to pandemic preparedness, and be poised to respond timely to a bioterrorist attack or other national and global emergencies caused by infectious pathogens. The BRL serves as a center for scientific collaboration to 1) generate advanced knowledge of pathogen biology and host interaction mechanisms, and 2) evaluate diagnostics, therapeutics and vaccines. To meet the mission, GMU must have an adequately sized and trained workforce who can conduct high quality work safely and in compliance with federal regulations; effectively operate advanced instrumentation; and generate reliable data to support faster transition of new discoveries to the market. It is critical that the BRL has a strong BSL-3 Practices core to ensure continued safe conduct of research in a high containment environment that complies with National Institutes of Allergy and Infectious Diseases (NIAID), Center for Disease Control (CDC), and US Department of Agriculture (USDA)/Animal and Plant Health and Inspection Service (APHIS) regulations. Creating and sustaining a compliant work environment for pathogen and select agent research is critical for the health and safety of laboratory operators and to prevent environmental exposure. The implementation strategies for GMU’s BSL-3 Practices core focus on 1) enhancing safety training by delivering a consistent, personalized curriculum, 2) implementing Good Laboratory Practices (GLP) to advance research quality and reproducibility, and 3) ensuring the BSL-3 research community can effectively utilize advanced research instrumentation through support and training by experienced members of the BRL applied research team.