Upgrade and operational improvements to the SouthEastern Biosafety Laboratory, Alabama, Birmingham (SEBLAB)

项目摘要/摘要： 该项目将对阿拉巴马州东南部生物安全实验室进行现代化改造和升级 伯明翰(SEBLAB)，并极大地扩展了可用于研究 新出现的传染病，以及其他严重影响人类健康的病原体。 拟议项目的范围包括三个具体目标： 1.基础设施更新 2.基础设施改正 3.研究设备 具体目标1：自2009年以来连续运行设备的自然磨损是 意义重大。这一特定目标下的物品将更换磨损、停产或陈旧的设备， 升级到最新技术，提高能源效率。 具体目标2：纠正仅在运行过程中实现、在设计过程中未预见到的问题 和建筑业。需要纠正的问题包括动态空气平衡，以确保适当的 定向气流，电源插座开关，以更适合敏感的研究设备，以及 对精选的生物安全设备进行现代化改造，以优化设施运营。 具体目标3：购买SEBLAB当前用户的高端研究设备 渴望，但不能通过其他方式获得(BD SYMPHONY S6细胞分类器，Milabs？CTUHROIFLT)。 像这样的最先进的设备对于在SEBLAB中继续进行高影响力的科学至关重要。 完成后，该项目将实现以下目标： 1.更新的设施基础设施既实用又节能，因此SEBLAB可以 继续为生物防御和新发传染病研究作出贡献。 2.优化SEBLAB的系统，以满足该设施的当前使用和预期需要。 3.为研究人员提供最好的工具，既加强研究 能力，并扩大SEBLAB研究的翻译影响。

Project Summary/Abstract: This project will modernize and upgrade the SouthEastern Biosafety Laboratory, Alabama Birmingham (SEBLAB), as well as greatly expand the research capabilities available for studies of newly emerging infectious diseases, and other agents of significant concern to human health. The scope of the proposed project includes three specific aims: 1. Infrastructure update 2. Infrastructure correction 3. Research equipment SPECIFIC AIM 1: Natural wear and tear on continuously running equipment since 2009 is significant. Items under this specific aim will replace worn, discontinued or obsolete equipment, upgrading to the latest technology and improving energy efficiency. SPECIFIC AIM 2: Correcting problems only realized during operation, unforeseen during design and construction. The issues needing correction include dynamic air balancing to ensure proper directional airflow, electrical outlet switch out to better suit sensitive research equipment, and modernizing select biosafety equipment to optimize facility operations. SPECIFIC AIM 3: The purchase of high-end research equipment the current users of SEBLAB desire, but cannot acquire by other means (BD Symphony S6 cell sorter, MILabs µCTUHROIFLT). State of the art equipment such as these are critical to continuing high impact science in SEBLAB. Upon completion, this project will achieve the following: 1. Updated facility infrastructure that is both functional and energy efficient, so SEBLAB can continue its contribution to biodefence and emerging infectious diseases research. 2. Optimization of the systems in SEBLAB for current use and expected needs of the facility. 3. Providing research staff with the best tools available, both enhancing research capabilities, and expanding translational impact of the research in SEBLAB.