Biocontainment Research Support Service(s) Core-Optional

项目摘要/摘要： 核心3概述了在UAB SEBLAB内建立综合核心服务的战略计划 能够安全和高效地使用最近由NIAID资助的尖端科学设备 奖项1G20AI167409-S1。该建议建立了六个功能整合的研究核心 内遏制包括：1。细胞培养核心，以保持和产生新的细胞系，2。 微生物核心用于培养生物，修改和维护库存，3.体外核心操作 高分辨率成像和高通量筛选平台，4.体内核心高运行 复杂的非侵入性成像平台，5.单细胞核心进行流式细胞术，细胞 分类，和单细胞分离，以及6.大流行防范核心，以开发医疗 对策和推动IRB批准的需要临床样本的高遏制研究。 每个核心将由一个科研团队运营，包括本申请的PI， 一名资深科学家和两名初级科学家。这个科学团队将与UAB密切合作 核心实验室主任、生物安全和SEBLAB最终用户，以优化高遏制研究 生产力。

Project Summary/Abstract: Core 3 outlines a strategic plan to establish integrated core services within the UAB SEBLAB enabling safe and efficient use of the cutting edge scientific equipment recently funded by NIAID award 1G20AI167409-S1. This proposal establishes six functional integrated research cores within containment including: 1. Cell Culture core to maintain and generate novel cell lines, 2. Microbiology core to culture organisms, modify, and maintain stocks, 3. In vitro core to operate high resolution imaging and high-throughput screening platforms, 4. In vivo core to operate high complexity non-invasive imaging platforms, 5. Single Cell core to perform flow cytometry, cell sorting, and single cell partitioning, and 6. Pandemic Preparedness core to develop medical countermeasures and drive IRB-approved high containment research requiring clinical samples. Each core will be operated by a scientific research team, including the PI on this application, one senior scientist, and two junior scientists. This scientific team will work closely with UAB Core lab directors, Biosafety, and SEBLAB end users to optimize high containment research productivity.