Biocontainment Research Support Service(s) Core-Optional

生物防护研究支持服务核心-可选

• 批准号: 10792753
• 负责人: Sixto Manuel Leal
• 金额: $ 84.2万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792753
• 关键词: Air; Alabama; Anesthesia procedures; Autopsy; Avian Influenza; Award; Biomedical Research; COVID-19 pandemic; Cell Culture Techniques; Cell Line; Cell Separation; Cells; Clinical; Collaborations; Consultations; Containment; Core Facility; Coronavirus; Decontamination; Development; Diagnostic tests; Drug Delivery Systems; Encephalitis Viruses; Equilibrium; Equine Encephalomyelitis; Equipment; Evaluation; Flow Cytometry; Fostering; Funding; Genetically Modified Organisms; Genotype; High Resolution Computed Tomography; Histoplasma; Human; Immune response; Immunology; In Vitro; Individual; Infection; Institutional Review Boards; Investments; Laboratories; Laboratory Research; Light; Liquid substance; Lung; Microbe; Microbiology; Microscopy; Mission; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Nebulizer; Organism; Output; Plaque Assay; Positron-Emission Tomography; Productivity; Pulmonary function tests; Recovery; Research; Research Infrastructure; Research Support; Resolution; Resources; Risk; Sampling; Scientist; Senior Scientist; Services; Solid; Strategic Planning; System; Technology; Translating; Translational Research; Universities; Variant; Venezuelan Equine Encephalomyelitis; Virus; Work; X-Ray Computed Tomography; animal imaging; biobank; biodefense; bioluminescence imaging; career preparation; chikungunya; exhaust; experimental study; fluorescence imaging; fungus; future outbreak; future pandemic; genetically modified cells; high resolution imaging; high throughput screening; imaging facilities; imaging platform; in vitro Assay; in vivo; in vivo imaging; innovation; insight; live cell imaging; medical countermeasure; microbial; new pandemic; non-invasive imaging; novel; operation; pandemic potential; pandemic preparedness; repaired; research clinical testing; single cell analysis; single photon emission computed tomography; skills; tissue processing; ultra high resolution

Project Summary/Abstract: Core 3 outlines a strategic plan to establish integrated core services within the UAB SEBLAB enabling safe and efficient use of the cutting edge scientific equipment recently funded by NIAID award 1G20AI167409-S1. This proposal establishes six functional integrated research cores within containment including: 1. Cell Culture core to maintain and generate novel cell lines, 2. Microbiology core to culture organisms, modify, and maintain stocks, 3. In vitro core to operate high resolution imaging and high-throughput screening platforms, 4. In vivo core to operate high complexity non-invasive imaging platforms, 5. Single Cell core to perform flow cytometry, cell sorting, and single cell partitioning, and 6. Pandemic Preparedness core to develop medical countermeasures and drive IRB-approved high containment research requiring clinical samples. Each core will be operated by a scientific research team, including the PI on this application, one senior scientist, and two junior scientists. This scientific team will work closely with UAB Core lab directors, Biosafety, and SEBLAB end users to optimize high containment research productivity.

项目概要/摘要： 核心3概述了在UAB SEBLAB内建立综合核心服务的战略计划 确保安全有效地使用最近由NIAID资助的尖端科学设备 授予1G 20 AI 167409-S1。该方案建立了六个功能集成研究核心 在安全壳内包括：1.细胞培养核心，以维持和产生新的细胞系，2. 微生物学核心培养有机体，修改，并保持股票，3.体外核心操作 高分辨率成像和高通量筛选平台，4.体内核心操作高 复杂的非侵入性成像平台，5.单细胞核心进行流式细胞术，细胞 分选和单细胞分配，以及6.大流行准备是发展医疗保健的核心 应对措施和推动IRB批准的需要临床样本的高遏制研究。 每个核心将由一个科研团队操作，包括本申请的PI， 一名资深科学家和两名初级科学家该科学团队将与UAB密切合作 核心实验室主任、生物安全和SEBLAB最终用户优化高遏制研究 生产力