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Biocontainment Research Support Service(s) Core-Optional

Biocontainment Research Support Service(s) Core-Optional
生物防护研究支持服务核心-可选
批准号:
10792753
负责人:
Sixto Manuel Leal
金额:
$84.2万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-08-18 至 2028-07-31
关键词:
AirAlabamaAnesthesia proceduresAutopsyAvian InfluenzaAwardBiomedical ResearchCOVID-19 pandemicCell Culture TechniquesCell LineCell SeparationCellsClinicalCollaborationsConsultationsContainmentCore FacilityCoronavirusDecontaminationDevelopmentDiagnostic testsDrug Delivery SystemsEncephalitis VirusesEquilibriumEquine EncephalomyelitisEquipmentEvaluationFlow CytometryFosteringFundingGenetically Modified OrganismsGenotypeHigh Resolution Computed TomographyHistoplasmaHumanImmune responseImmunologyIn VitroIndividualInfectionInstitutional Review BoardsInvestmentsLaboratoriesLaboratory ResearchLightLiquid substanceLungMicrobeMicrobiologyMicroscopyMissionMycobacterium tuberculosisNational Institute of Allergy and Infectious DiseaseNebulizerOrganismOutputPlaque AssayPositron-Emission TomographyProductivityPulmonary function testsRecoveryResearchResearch InfrastructureResearch SupportResolutionResourcesRiskSamplingScientistSenior ScientistServicesSolidStrategic PlanningSystemTechnologyTranslatingTranslational ResearchUniversitiesVariantVenezuelan Equine EncephalomyelitisVirusWorkX-Ray Computed Tomographyanimal imagingbiobankbiodefensebioluminescence imagingcareer preparationchikungunyaexhaustexperimental studyfluorescence imagingfungusfuture outbreakfuture pandemicgenetically modified cellshigh resolution imaginghigh throughput screeningimaging facilitiesimaging platformin vitro Assayin vivoin vivo imaginginnovationinsightlive cell imagingmedical countermeasuremicrobialnew pandemicnon-invasive imagingnoveloperationpandemic potentialpandemic preparednessrepairedresearch clinical testingsingle cell analysissingle photon emission computed tomographyskillstissue processingultra high resolution

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Project Summary/Abstract: Core 3 outlines a strategic plan to establish integrated core services within the UAB SEBLAB enabling safe and efficient use of the cutting edge scientific equipment recently funded by NIAID award 1G20AI167409-S1. This proposal establishes six functional integrated research cores within containment including: 1. Cell Culture core to maintain and generate novel cell lines, 2. Microbiology core to culture organisms, modify, and maintain stocks, 3. In vitro core to operate high resolution imaging and high-throughput screening platforms, 4. In vivo core to operate high complexity non-invasive imaging platforms, 5. Single Cell core to perform flow cytometry, cell sorting, and single cell partitioning, and 6. Pandemic Preparedness core to develop medical countermeasures and drive IRB-approved high containment research requiring clinical samples. Each core will be operated by a scientific research team, including the PI on this application, one senior scientist, and two junior scientists. This scientific team will work closely with UAB Core lab directors, Biosafety, and SEBLAB end users to optimize high containment research productivity.
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The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity
Facility Management, Maintenance and Operations Core
Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support
BSL-3 Practices Core
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