Augmenting Scientific Discovery and Research Infrastructure in the UAB Regional Biocontainment Laboratory (SEBLAB)

增强 UAB 区域生物防护实验室 (SEBLAB) 的科学发现和研究基础设施

基本信息

  • 批准号:
    10626482
  • 负责人:
  • 金额:
    $ 433万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-23 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

Project Summary: The current proposal outlines a strategic plan to implement novel technologies within containment that will advance the NIAID mission to support pandemic preparedness and biomedical research on risk group III (RGIII) pathogens. This proposal focuses on the implementation of cutting edge equipment to advance in vitro (Aim1), in vivo (Aim2), and molecular investigation (Aim3) of high containment pathogens and also seeks to build upon the diagnostic expertise of the Scientific Director to establish a high containment molecular infrastructure capable of rapidly responding to future emerging pandemic threats with rapid diagnostic test development and real-world implementation for patient care and public health intervention. Innovations include: 1) First proposal seeking to acquire cutting edge equipment to increase scientific productivity at University of Alabama at Birmingham (UAB)’s SEBLAB, 2) Novel use of the Zeiss lattice light-sheet microscope within containment, 3) Innovative implementation of ultra-high resolution computed tomography and PET/SPECT capabilities enabling use of novel radionuclides generated by the nation’s largest TR24 cyclotron (UAB) for non-invasive diagnostic imaging research on RGIII pathogens, 4) Create the ability to perform bioenergetic analyses and single cell sequencing at SEBLAB, and 5) Implement molecular infrastructure within containment enabling rapid diagnostic test development and validation with a clear path to implementation in CLIA/CAP-accredited clinical and public health laboratories. Given the current pandemic, risks for future outbreaks, and rapid advancement of research technologies, investment in the UAB SEBLAB as outlined in the current proposal will translate into real-world impacts on pandemic preparedness and accelerate hyper-competitive basic biomedical and translational research output that advances our basic understanding and biodefense capabilities against high containment pathogens.
项目概述:目前的提案概述了一个战略计划,以实施新颖

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Sixto Manuel Leal其他文献

Sixto Manuel Leal的其他文献

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{{ truncateString('Sixto Manuel Leal', 18)}}的其他基金

The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity
SARS-CoV-2 免疫失调对抗真菌免疫的影响
  • 批准号:
    10658355
  • 财政年份:
    2023
  • 资助金额:
    $ 433万
  • 项目类别:
Facility Management, Maintenance and Operations Core
设施管理、维护和运营核心
  • 批准号:
    10792751
  • 财政年份:
    2023
  • 资助金额:
    $ 433万
  • 项目类别:
Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support
提高 SEBLAB 研究生产力、运营和核心实验室支持
  • 批准号:
    10792750
  • 财政年份:
    2023
  • 资助金额:
    $ 433万
  • 项目类别:
Biocontainment Research Support Service(s) Core-Optional
生物防护研究支持服务核心-可选
  • 批准号:
    10792753
  • 财政年份:
    2023
  • 资助金额:
    $ 433万
  • 项目类别:
BSL-3 Practices Core
BSL-3 实践核心
  • 批准号:
    10792752
  • 财政年份:
    2023
  • 资助金额:
    $ 433万
  • 项目类别:
The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity
SARS-CoV-2 免疫失调对抗真菌免疫的影响
  • 批准号:
    10668549
  • 财政年份:
    2022
  • 资助金额:
    $ 433万
  • 项目类别:
Upgrade and operational improvements to the SouthEastern Biosafety Laboratory, Alabama, Birmingham (SEBLAB)
阿拉巴马州伯明翰东南生物安全实验室 (SEBLAB) 的升级和运营改进
  • 批准号:
    10394580
  • 财政年份:
    2021
  • 资助金额:
    $ 433万
  • 项目类别:
The Pathogenesis of Aspergillus Keratitis
曲霉菌性角膜炎的发病机制
  • 批准号:
    7923157
  • 财政年份:
    2009
  • 资助金额:
    $ 433万
  • 项目类别:
The Pathogenesis of Aspergillus Keratitis
曲霉菌性角膜炎的发病机制
  • 批准号:
    8128621
  • 财政年份:
    2009
  • 资助金额:
    $ 433万
  • 项目类别:
The Pathogenesis of Aspergillus Keratitis
曲霉菌性角膜炎的发病机制
  • 批准号:
    8326714
  • 财政年份:
    2009
  • 资助金额:
    $ 433万
  • 项目类别:

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