Helping Us Grow Stronger (HUGS/Abrazos): COVID-19 in pregnancy and reducing toxic stress in mother-infant dyads

帮助我们变得更强 (HUGS/Abrazos)：怀孕期间的 COVID-19 和减少母婴二人的毒性压力

• 批准号: 10393329
• 负责人: Andrea Goldberg Edlow
• 金额: $ 42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393329
• 关键词: 2019-nCoV; Anxiety; Area; Biological; Boston; Brain; Buffers; COVID-19; COVID-19 diagnosis; COVID-19 pandemic; COVID-19 vaccine; Child; Collection; Color; Communities; Community Health Aides; Country; Data; Discrimination; Economics; Emergency Situation; Enrollment; Environment; Epidemic; Exposure to; Family; Fostering; General Hospitals; Goals; Health; Immune; Individual; Infant; Infant Health; Inflammation; Inflammatory; Inflammatory Response; Institutional Racism; Intervention; Knowledge; Lactation; Latinx; Lead; Massachusetts; Maternal Exposure; Maternal Health; Maternal Mortality; Maternal and Child Health; Measures; Mental Depression; Mental Health; Metabolic; Mothers; Outcome; Participant; Patients; Perinatal; Perinatal Exposure; Personal Satisfaction; PhenX Toolkit; Population; Post-Traumatic Stress Disorders; Postpartum Women; Pregnancy; Pregnant Women; Quality of life; Research Personnel; Resources; Risk; SARS-CoV-2 infection; SARS-CoV-2 positive; Sampling; Serum; Social Workers; Specimen; Stress; Surveys; Testing; Time; Treatment Efficacy; United States; Woman; Work; base; behavioral health; biobank; clinical phenotype; cohort; community engaged research; coronavirus disease; cytokine; design; early childhood; effective intervention; efficacy evaluation; experience; fetal; fetal programming; food insecurity; fourth trimester; health data; high risk; high risk population; immune activation; improved; in utero; insight; instrument; maternal obesity; maternal risk; maternal stress; member; novel; pandemic disease; post intervention; postnatal; pregnant; prenatal exposure; programs; racism; recruit; resilience; social; social health determinants; stressor; vaccine efficacy

PROJECT SUMMARY Pregnancy and early childhood mark a unique period when two lives can be permanently impacted by the presence of maternal stressors such as economic instability, poor mental health, and social inequities, all of which have been amplified by the COVID-19 pandemic. The COVID pandemic has also collided with the epidemics of racism and maternal mortality plaguing the United States, to disproportionately impact already- marginalized Black and Latinx pregnant individuals in the greater Boston area. In the absence of protective buffers, prolonged exposure to excessive adversity (“toxic stress”) can lead to poor health outcomes for both mothers and infants. Effective interventions to improve maternal mental health and mitigate social determinants of health in individuals with COVID-19 in pregnancy are therefore urgently needed. Helping Us Grow Stronger (HUGS/Abrazos) is a community-based program, designed and launched during the COVID pandemic. HUGS/Abrazos combines emergency relief, patient navigation, and direct behavioral health support to foster resilience and mitigate the negative impacts of COVID-related toxic stress on pregnant and postpartum women and their families. Participants enrolled in Massachusetts General Hospital’s COVID-19 Pregnancy Biorepository will be referred to the HUGS/Abrazos program if they test positive for SARS-CoV-2. Using validated survey instruments, we will assess the extent to which the program improves maternal stress, anxiety, depression, quality of life, food insecurity, and experiences of racism and discrimination in this high-risk pregnant population. We will also assess the impact of maternal COVID-19-associated inflammation on behavioral health outcomes using cytokine analysis of banked serum samples from the participants. This urgent competitive revision of the R01 “Fetal Brain-Placental Immune Activation in Maternal Obesity” is aligned with the R01’s long-term translational goals: to understand how in utero exposure to maternal inflammation and immune activation impacts fetal programming, in order to create targeted interventions that can improve short- and long-term maternal and child health outcomes in the face of maternal exposures. This work will generate key knowledge about the efficacy of a novel community-based intervention to reduce the adverse impact of maternal SARS-CoV-2 infection on the mother-infant dyad, and improve transgenerational outcomes.

项目总结