Synergy of lipolysis and lipophagy in alcoholic liver disease

项目摘要/摘要 本补充文件的目的和范围是提供额外资金以缓解中断 由柯萨奇病毒19大流行引起的与我父母赠款有关的研究和培训活动 (K99 AA026877)。家长基金试图定义脂肪分解代谢的新机制。 影响酒精性肝病(ALD)。在此期间的研究活动将解决 特定目标2，它试图定义一种新的、基于内切溶酶体的机制 受饮酒影响的微脂类吞噬作用。此外，这一补充将允许 我要完成我提出的使用ALD动物模型的培训。取得了良好的效果 将提供对脂滴分解代谢的机制的理解 酒精性脂肪肝。重要的是，这些研究将提供已出版的研究手稿 以及支持未来R01提案的初步数据。

Project Summary/Abstract The purpose and scope of this supplement is to provide additional funds to mitigate disruptions caused by the COVID19 pandemic on research and training activities related to my parent grant (K99 AA026877). The parent grant seeks to define new mechanisms of lipid catabolism affecting alcoholic liver disease (ALD). The research activities during this period will address Specific Aim 2, which seeks to define a novel, endo-lysosome based mechanism of microlipophagy that is impacted by alcohol consumption. In addition, this supplement will allow me to complete my proposed training in the use of animal models of ALD. The results gained from the proposed research will provide a mechanistic understanding of lipid droplet catabolism in alcoholic fatty liver. Importantly, these studies will provide published research manuscripts and preliminary data in support of a future R01 proposal.