Synergy of lipolysis and lipophagy in alcoholic liver disease

项目概要/摘要 这一补充的目的和范围是提供额外的资金，以减轻干扰 COVID-19大流行导致的研究和培训活动与我的父母补助金有关 (K99 AA026877）。家长补助金旨在确定脂质代谢的新机制 酒精性肝病（ALD）在此期间的研究活动将解决 具体目标2，旨在定义一种新的，基于内溶酶体的机制， 这是由酒精消费的影响。此外，这一补充将使 我完成我提出的关于使用ALD动物模型的培训。获得的结果 从拟议的研究将提供一个机制的理解脂滴catalysts 酒精性脂肪肝重要的是，这些研究将提供已发表的研究手稿 以及支持未来R 01提案的初步数据。

Project Summary/Abstract The purpose and scope of this supplement is to provide additional funds to mitigate disruptions caused by the COVID19 pandemic on research and training activities related to my parent grant (K99 AA026877). The parent grant seeks to define new mechanisms of lipid catabolism affecting alcoholic liver disease (ALD). The research activities during this period will address Specific Aim 2, which seeks to define a novel, endo-lysosome based mechanism of microlipophagy that is impacted by alcohol consumption. In addition, this supplement will allow me to complete my proposed training in the use of animal models of ALD. The results gained from the proposed research will provide a mechanistic understanding of lipid droplet catabolism in alcoholic fatty liver. Importantly, these studies will provide published research manuscripts and preliminary data in support of a future R01 proposal.