Synergy of lipolysis and lipophagy in alcoholic liver disease
脂肪分解和脂肪吞噬在酒精性肝病中的协同作用
基本信息
- 批准号:10392064
- 负责人:
- 金额:$ 4.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-20 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:Acid LipaseAddressAdipocytesAdipose tissueAdrenergic AgentsAffectAlcohol consumptionAlcoholic Fatty LiverAlcoholic Liver DiseasesAlcoholic beverage heavy drinkerAnimal ModelAutophagocytosisAutophagosomeBiochemistryBiologicalBiologyCOVID-19 pandemicCatabolismCellsChronicCirrhosisClinicCyclic AMPCyclic AMP-Dependent Protein KinasesDataDevelopmentDisease ProgressionElderlyEndosomesEnvironmentEnzymesEthanolEventFatty LiverFibrosisFundingFutureGastroenterologyGenetic TranscriptionGoalsHepaticHepatitisHepatocyteHepatologyHydrolysisImpairmentKnowledgeLipaseLipidsLipolysisLiverLysosomesMalignant NeoplasmsManuscriptsMass Spectrum AnalysisMediatingMembraneMicroscopyMultivesicular BodyObesityOutcomePathway interactionsPeripheralPharmacologyPharmacotherapyPhasePhosphotransferasesPreventionProcessProtein KinaseProtein SortingsProtein phosphataseProteinsProteomeProteomicsPublishingRegulationResearchResearch ActivityRodent ModelSignal TransductionSurfaceTestingTrainingTraining ActivityTriglyceridesVesicleWorkbasechronic alcohol ingestionin vivoinsightliver injurynovelparent grantproblem drinkerprotein activationpublic health relevancereceptorrecruitresponsesterol esterasesynergismtraffickingtranscription factor
项目摘要
Project Summary/Abstract
The purpose and scope of this supplement is to provide additional funds to mitigate disruptions
caused by the COVID19 pandemic on research and training activities related to my parent grant
(K99 AA026877). The parent grant seeks to define new mechanisms of lipid catabolism
affecting alcoholic liver disease (ALD). The research activities during this period will address
Specific Aim 2, which seeks to define a novel, endo-lysosome based mechanism of
microlipophagy that is impacted by alcohol consumption. In addition, this supplement will allow
me to complete my proposed training in the use of animal models of ALD. The results gained
from the proposed research will provide a mechanistic understanding of lipid droplet catabolism
in alcoholic fatty liver. Importantly, these studies will provide published research manuscripts
and preliminary data in support of a future R01 proposal.
项目总结/摘要
这一补充的目的和范围是提供额外的资金,以减轻干扰
COVID-19大流行导致的研究和培训活动与我的父母补助金有关
(K99 AA026877)。家长补助金旨在确定脂质代谢的新机制
酒精性肝病(ALD)在此期间的研究活动将解决
具体目标2,旨在定义一种新的,基于内溶酶体的机制,
微脂吞噬作用受到酒精消耗的影响。此外,这一补充将使
我完成我提出的关于使用ALD动物模型的培训。获得的结果
从拟议的研究将提供一个机制的理解脂滴catalysts
酒精性脂肪肝重要的是,这些研究将提供已发表的研究手稿
以及支持未来R 01提案的初步数据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Micah Schott其他文献
Micah Schott的其他文献
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{{ truncateString('Micah Schott', 18)}}的其他基金
Mechanisms of endosomal trafficking in lipid droplet catabolism
脂滴分解代谢中的内体运输机制
- 批准号:
10714356 - 财政年份:2023
- 资助金额:
$ 4.1万 - 项目类别:
Mechanisms of lipid droplet trafficking in hepatocellular carcinoma
肝细胞癌中脂滴运输的机制
- 批准号:
10644812 - 财政年份:2023
- 资助金额:
$ 4.1万 - 项目类别:
Synergy of lipolysis and lipophagy in alcoholic liver disease
脂肪分解和脂肪吞噬在酒精性肝病中的协同作用
- 批准号:
10489818 - 财政年份:2021
- 资助金额:
$ 4.1万 - 项目类别:
Synergy of lipolysis and lipophagy in alcoholic liver disease
脂肪分解和脂肪吞噬在酒精性肝病中的协同作用
- 批准号:
10455130 - 财政年份:2021
- 资助金额:
$ 4.1万 - 项目类别:
Synergy of lipolysis and lipophagy in alcoholic liver disease
脂肪分解和脂肪吞噬在酒精性肝病中的协同作用
- 批准号:
10686384 - 财政年份:2021
- 资助金额:
$ 4.1万 - 项目类别:
Mechanisms of Lipid Heterogeneity in Lipid Droplet Catabolism
脂滴分解代谢中脂质异质性的机制
- 批准号:
10714244 - 财政年份:2018
- 资助金额:
$ 4.1万 - 项目类别:
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