Innovation Fund Application to the Multicenter AIDS Cohort Study MACS/WIHS Combined Cohort Study (MWCCS) COVID-19 Vaccine Acceptance and Hesitancy (CVHB) Study in People with HIV

MWCCS参与者是严重COVID-19疾病的高风险群体，因为他们感染了艾滋病毒， 主要是老年人，并有许多潜在的合并症。因此，当务之急是 为了他们的健康，他们必须接种新的COVID-19疫苗。然而，迄今为止， 只有关于COVID-19疫苗在艾滋病毒感染者（PWH）中接受和有效性的轶事数据。的 MWCCS是分析（a）COVID-19疫苗在男性和女性中的接受性和效果的理想工具 PWH和匹配的HIV未感染对照（HUC），（B）年龄和合并症对疫苗的影响 免疫反应和对COVID-19的保护，以及（c）社会，经济和行为 COVID-19免疫接种后的变化，与选择不接种疫苗的个体相比， 疫苗

MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV-uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who opted to not take the vaccine.