Innovation Fund Application to the Multicenter AIDS Cohort Study MACS/WIHS Combined Cohort Study (MWCCS) COVID-19 Vaccine Acceptance and Hesitancy (CVHB) Study in People with HIV

就感染艾滋病毒而言，MWCCS参与者是严重新冠肺炎疾病的高危人群， 主要是老年人，并有许多潜在的合并症。因此，它势在必行。 为了他们的健康，他们接种了新的新冠肺炎疫苗。然而，到目前为止，有 仅有关于新冠肺炎疫苗在艾滋病毒携带者(PWH)中的接受度和有效性的坊间数据。这个 MWCCS是分析(A)新冠肺炎(S)疫苗在男性和女性中的接受度和效果的理想工具 Pwh和匹配的艾滋病毒非感染对照(Huc)，(B)年龄和合并疾病对疫苗的影响 针对新冠肺炎的免疫反应和保护，以及(C)社会、经济和行为 新冠肺炎免疫后的变化与选择不接种 疫苗。

MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV-uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who opted to not take the vaccine.