Innovation Fund Application to the Multicenter AIDS Cohort Study MACS/WIHS Combined Cohort Study (MWCCS) COVID-19 Vaccine Acceptance and Hesitancy (CVHB) Study in People with HIV

创新基金申请多中心艾滋病队列研究 MACS/WIHS 联合队列研究 (MWCCS) HIV 感染者的 COVID-19 疫苗接受和犹豫 (CVHB) 研究

• 批准号: 10392708
• 负责人: ADAORA A ADIMORA
• 金额: $ 2.67万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392708
• 关键词: 2019-nCoV; Address; Age; Aging; Attenuated; Awareness; Behavioral; Behavioral Research; Black race; COVID-19; COVID-19 vaccine; Cardiovascular system; Characteristics; Chronic; Cohort Studies; Collaborations; Communication; Complement; Data; Development; Disease; Economics; Elderly; Eligibility Determination; Epidemiologic Methods; Female; Foundations; Funding; Future; Gender; HIV; HIV Infections; Health; Immune response; Immunization; Immunize; Incidence; Individual; Infection; Longitudinal observational study; Lung; Measures; Mediating; Medical; Medical Records; Methods; Monitor; Neurocognitive; North Carolina; Outcome; Participant; Pathogenesis; Patient Self-Report; Population; Prevalence; Research; Research Personnel; SARS-CoV-2 infection; Science; Serology; Social status; Specimen; Surveys; The Multicenter AIDS Cohort Study; Time; Universities; Vaccinated; Vaccination; Vaccines; Woman; Women' s Interagency HIV Study; adjudication; clinical research site; comorbidity; disease phenotype; follow-up; high risk; high risk population; improved; innovation; instrument; male; male health; men; multidisciplinary; severe COVID-19; social; social epidemiology; vaccine acceptance; vaccine efficacy; vaccine hesitancy

MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV-uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who opted to not take the vaccine.

MWCCS参与者是严重COVID-19疾病的高风险群体，因为他们感染了艾滋病毒， 主要是老年人，并有许多潜在的合并症。因此，当务之急是 为了他们的健康，他们应该接种新的COVID-19疫苗。然而，迄今为止， 只有关于COVID-19疫苗在艾滋病毒感染者（PWH）中接受和有效性的轶事数据。的 MWCCS是分析（a）COVID-19疫苗在男性和女性中的接受性和效果的理想工具 PWH和匹配的HIV未感染对照（HUC），（B）年龄和合并症对疫苗的影响 免疫反应和对COVID-19的保护，以及（c）社会，经济和行为 COVID-19免疫接种后的变化，与选择不接种疫苗的个体相比， 疫苗