NIGMS Administrative Supplements to Support Undergraduate Summer Research

家长补助金行政副刊R01 GM128145 应对计算基因组注释的开放挑战 派·马克·博罗多夫斯基 摘要 改进真核生物基因组中的基因发现是亲本的一大部分和重要部分 求婚。与佐治亚理工学院院长名单上的大三学生安德烈·扎兹纳耶夫在一起，他非常 有兴趣在计算生物学方面做出贡献，我们将致力于其他目标 开发一种改进的真核基因组基因预测算法的建议 它们的区别在于它们的复杂性-基因组GC的长、短程不均一性 组成。本科生将创建用于生成GC库的工具- 每个基因组中蛋白质编码区的依赖模型。他还将开发一个扩展 将能够使用新模型的基因发现算法。

Administrative Supplement to Parent Grant R01 GM128145 Addressing Open Challenges of Computational Genome Annotation PI Mark Borodovsky Abstract Improving gene finding in eukaryotic genomes is a large and important part of the parent proposal. With Andrey Zaznaev, the Georgia Tech Deans’s list junior student, who is very interested in making contribution in computational biology, we will work on additional aim of the proposal – developing an improved algorithm for gene prediction in eukaryotic genomes that are distinguished by their complexity - long- and short-range inhomogeneity of genome GC composition. The undergraduate student will create tools for generating a library of GC- dependent models of protein-coding regions in each genome. He also will develop an extension of the gene finding algorithm that will be able to use the new models.