Childhood Asthma in Urban Settings

城市环境中的儿童哮喘

• 批准号: 10393042
• 负责人: PAULA J BUSSE
• 金额: $ 43.28万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393042
• 关键词: Address; Adolescent; Adolescent obesity; Allergens; Allergic Disease; Area; Arginine; Asthma; Atopic Dermatitis; Blood; Caring; Child; Childhood; Childhood Asthma; Clinical; Clinical Research; Cutaneous; Data; Dietary Supplementation; Disease; Ensure; Environmental Exposure; Epidemiology; Equilibrium; Ethnic Origin; Extrinsic asthma; Funding; Future; Health system; Healthcare Systems; Hospitals; Hypersensitivity; Immune response; Immunology; Impairment; Individual; Inflammation; Intervention; Intervention Studies; Laboratories; Laboratory Technicians; Lead; Literature; Microbe; Minority Groups; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; New York City; Nitric Oxide; Nurses; Obesity; Outcome; Pathogenicity; Pathway interactions; Pattern; Pharmacists; Phenotype; Population; Populations at Risk; Positioning Attribute; Poverty; Process; Proteomics; Protocols documentation; Research; Research Contracts; Research Personnel; Research Project Grants; Risk; Risk Factors; Sampling; Self Management; Severity of illness; Site; Skin; Systems Biology; United States National Institutes of Health; Urban Population; Work; airway inflammation; base; burden of illness; comorbidity; experience; health care disparity; high risk; high risk population; improved; innovation; interest; member; metropolitan; microbiome; mortality; novel; novel therapeutics; personalized therapeutic; programs; prospective; recruit; research study; respiratory; success; support network; transcriptomics; urban children; urban minority; urban setting

The overall objective of this study is to provide the NIAID Childhood Asthma in Urban Settings Clinical Research Network Center (CAUSE) with a highly developed and experienced Clinical Research Center (CRC) at the Mount Sinai Health Care System. We propose that the Mount Sinai Health Care System is well- positioned and prepared to create a NIAID CAUSE-CRC to conduct Network and Center-specific studies based upon: 1) Our success recruiting and retaining subjects in asthma studies from urban populations; 2) Investigators actively conducting innovative research to understand mechanisms of atopic diseases; 3) Established and well-organized clinical research programs with committed staff to conduct research studies; 4) Facilities and institutional support to ensure the success of this proposal; and 5) A large population of high risk urban children/adolescents with asthma who receive care and participate in research at the Mount Sinai Health System. The proposed Mount Sinai CAUSE-CRC includes a team of investigators with strong backgrounds relevant to asthma, allergy, immunology, epidemiology, transcriptomics, microbiome, and systems biology who have previously collaborated. MPIs Drs. Busse, Bunyavanich and Wisnivesky have served as PIs on several NIH and PCORI-sponsored asthma and allergic diseases networks (including ICAC-II, III sub-studies) and individually funded studies investigating determinants of asthma self-management, disparities in care, mechanisms of airway inflammation, -omics, and systems biology. The Mount Sinai CRC is supported by Co- Investigators Drs. Wright and Miller who have extensive experience in pediatric asthma network studies. Our team includes research coordinators, nurses, laboratory technicians, statisticians, bioinformaticians, pharmacists, and regulatory members who have worked with the investigators which will allow us to successfully recruit, conduct protocols, maintain the integrity of study data, and coordinate with the LC and Contract Research Organizations. Our Center-specific project 1, will investigate the influence of concurrent AD on asthma control in urban children and will be conducted with Dr. Guttman-Yassky, an expert in atopic dermatitis at Mount Sinai. Project 2 will investigate the association between L-Arginine/Asymmetric Dimethyl Arginine and asthma morbidity in obese urban adolescents with asthma. Our individual research projects provide novel information on the mechanisms and a future treatment approach with a more precise benefit in children with asthma and AD in an urban setting.

本研究的总体目标是提供NIAID儿童哮喘在城市环境中的临床应用 研究网络中心(CAUSE)，拥有高度发达和经验丰富的临床研究中心(CRC) 在西奈山医疗保健系统。我们建议西奈山医疗保健系统很好地- 定位并准备创建NIAID事业-CRC进行特定于网络和中心的研究 基于：1)我们成功地从城市人群中招募和留住了哮喘研究对象；2) 研究人员积极开展创新研究，了解特应性疾病的发病机制；3) 建立和组织良好的临床研究计划，并有致力于开展研究的工作人员；4) 确保这项提议成功的设施和机构支持；以及5)大量高风险人群 在西奈山健康中心接受护理和参与研究的患有哮喘的城市儿童/青少年 系统。拟议的西奈山事业-CRC包括一支具有强大背景的调查团队 与哮喘、过敏、免疫学、流行病学、转录组学、微生物组和系统生物学有关的世卫组织 之前都有过合作。MPIs巴斯博士、布尼亚瓦尼奇和维斯尼夫斯基曾在几家公司担任私人助理 NIH和PCORI赞助的哮喘和过敏性疾病网络(包括ICAC-II、III分研究)和 个人资助的研究调查哮喘自我管理的决定因素，护理上的差异， 呼吸道炎症机制、组学和系统生物学。西奈山儿童基金会由Co- 研究人员莱特博士和米勒博士在儿童哮喘网络研究方面拥有丰富的经验。我们的 团队包括研究协调员、护士、实验室技术人员、统计学家、生物信息学家、 药剂师，以及与调查人员合作的监管成员，这将使我们能够 成功招募，执行方案，维护研究数据的完整性，并与LC和 合同研究机构。我们的中心特定项目1，将调查并发AD的影响 将与特应性疾病专家Guttman-Yassky博士一起进行 西奈山的皮炎。项目2将研究L-精氨酸/不对称二甲基间的联系。 患有哮喘的肥胖城市青少年的精氨酸和哮喘发病率。我们的个人研究项目 提供有关机制的新信息和未来的治疗方法，以获得更准确的 城市环境中患有哮喘和阿尔茨海默病的儿童。