Childhood Asthma in Urban Settings
城市环境中的儿童哮喘
基本信息
- 批准号:10211261
- 负责人:
- 金额:$ 43.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-15 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdolescent obesityAllergensAllergic DiseaseAreaArginineAsthmaAtopic DermatitisBloodCaringChildChildhoodChildhood AsthmaClinicalClinical ResearchCutaneousDataDietary SupplementationDiseaseEnsureEnvironmental ExposureEpidemiologyEquilibriumEthnic OriginExtrinsic asthmaFundingFutureHealth systemHealthcare SystemsHospitalsHypersensitivityImmune responseImmunologyImpairmentIndividualInflammationInterventionIntervention StudiesLaboratoriesLaboratory TechniciansLeadLiteratureMicrobeMinority GroupsMorbidity - disease rateNational Institute of Allergy and Infectious DiseaseNew York CityNitric OxideNursesObesityOutcomePathogenicityPathway interactionsPatternPharmacistsPhenotypePopulationPopulations at RiskPositioning AttributePovertyProcessProteomicsProtocols documentationResearchResearch ContractsResearch PersonnelResearch Project GrantsRiskRisk FactorsSamplingSelf ManagementSeverity of illnessSiteSkinSystems BiologyUnited States National Institutes of HealthUrban PopulationWorkairway inflammationbaseburden of illnesscomorbidityexperiencehealth care disparityhigh riskhigh risk populationimprovedinnovationinterestmembermetropolitanmicrobiomemortalitynovelnovel therapeuticspersonalized therapeuticprogramsprospectiverecruitresearch studyrespiratorysuccesssupport networktranscriptomicsurban childrenurban minorityurban setting
项目摘要
The overall objective of this study is to provide the NIAID Childhood Asthma in Urban Settings Clinical
Research Network Center (CAUSE) with a highly developed and experienced Clinical Research Center (CRC)
at the Mount Sinai Health Care System. We propose that the Mount Sinai Health Care System is well-
positioned and prepared to create a NIAID CAUSE-CRC to conduct Network and Center-specific studies
based upon: 1) Our success recruiting and retaining subjects in asthma studies from urban populations; 2)
Investigators actively conducting innovative research to understand mechanisms of atopic diseases; 3)
Established and well-organized clinical research programs with committed staff to conduct research studies; 4)
Facilities and institutional support to ensure the success of this proposal; and 5) A large population of high risk
urban children/adolescents with asthma who receive care and participate in research at the Mount Sinai Health
System. The proposed Mount Sinai CAUSE-CRC includes a team of investigators with strong backgrounds
relevant to asthma, allergy, immunology, epidemiology, transcriptomics, microbiome, and systems biology who
have previously collaborated. MPIs Drs. Busse, Bunyavanich and Wisnivesky have served as PIs on several
NIH and PCORI-sponsored asthma and allergic diseases networks (including ICAC-II, III sub-studies) and
individually funded studies investigating determinants of asthma self-management, disparities in care,
mechanisms of airway inflammation, -omics, and systems biology. The Mount Sinai CRC is supported by Co-
Investigators Drs. Wright and Miller who have extensive experience in pediatric asthma network studies. Our
team includes research coordinators, nurses, laboratory technicians, statisticians, bioinformaticians,
pharmacists, and regulatory members who have worked with the investigators which will allow us to
successfully recruit, conduct protocols, maintain the integrity of study data, and coordinate with the LC and
Contract Research Organizations. Our Center-specific project 1, will investigate the influence of concurrent AD
on asthma control in urban children and will be conducted with Dr. Guttman-Yassky, an expert in atopic
dermatitis at Mount Sinai. Project 2 will investigate the association between L-Arginine/Asymmetric Dimethyl
Arginine and asthma morbidity in obese urban adolescents with asthma. Our individual research projects
provide novel information on the mechanisms and a future treatment approach with a more precise benefit in
children with asthma and AD in an urban setting.
本研究的总体目标是为NIAID儿童哮喘在城市环境中的临床应用提供依据
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PAULA J BUSSE其他文献
PAULA J BUSSE的其他文献
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{{ truncateString('PAULA J BUSSE', 18)}}的其他基金
Depression in Older Asthmatics: Understanding Inflammatory and Behavioral Pathways
老年哮喘患者的抑郁症:了解炎症和行为途径
- 批准号:
10418660 - 财政年份:2019
- 资助金额:
$ 43.13万 - 项目类别:
Depression in Older Asthmatics: Understanding Inflammatory and Behavioral Pathways
老年哮喘患者的抑郁症:了解炎症和行为途径
- 批准号:
10164846 - 财政年份:2019
- 资助金额:
$ 43.13万 - 项目类别:
Airway Cellular and Cytokine Profiles in Older Patients with Asthma
老年哮喘患者的气道细胞和细胞因子谱
- 批准号:
8716660 - 财政年份:2013
- 资助金额:
$ 43.13万 - 项目类别:
Airway Cellular and Cytokine Profiles in Older Patients with Asthma
老年哮喘患者的气道细胞和细胞因子谱
- 批准号:
8586093 - 财政年份:2013
- 资助金额:
$ 43.13万 - 项目类别:
C1 ESTERASE INHIBITOR AS TREATMENT AND PREVENTION IN HEREDITARY ANGIOEDEMA
C1 酯酶抑制剂治疗和预防遗传性血管性水肿
- 批准号:
7953680 - 财政年份:2009
- 资助金额:
$ 43.13万 - 项目类别:
EFFICACY AND SAFETY OF PURIFIED C1 ESTERASE INHIBITOR FOR TREATMENT OF HAE
纯化 C1 酯酶抑制剂治疗 HAE 的功效和安全性
- 批准号:
7605311 - 财政年份:2007
- 资助金额:
$ 43.13万 - 项目类别:
Contribution of TNF-alpha to mucus cell production in asthma
TNF-α 对哮喘粘液细胞产生的贡献
- 批准号:
7143457 - 财政年份:2006
- 资助金额:
$ 43.13万 - 项目类别:
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Studentship