UC Denver Diabetes Research Center

中心概述 项目摘要/摘要 科罗拉多大学丹佛分校(UC Denver)以基础糖尿病、转化性糖尿病和临床糖尿病闻名世界 1型和2型糖尿病(T1D和T2D)及其相关并发症的研究和治疗。这个 拟建的科罗拉多大学糖尿病研究中心(UC Denver DRC)将加强糖尿病研究 在科罗拉多州提供：1)最先进的研究技术和专业资源，以最大限度地 有效和创新的研究；2)获取患者样本和数据；3)丰富计划、教育 以及4)通过以下方式吸引新的科学家进入糖尿病领域 试点和可行性计划。这些目标将通过提供改善的基础设施和 获得专门试剂和资源，以及促进科学互动、研究 糖尿病治疗和治愈方面的发现和进展。加州大学丹佛分校将主要位于 在科罗拉多州奥罗拉市快速发展的安舒茨医学院(AMC)上，加州大学的大部分学生 丹佛的临床和研究部门都设在这里。这一独特的多医院和学术园区 配置允许广泛的糖尿病研究基础，目前包括88个基础、翻译和 加州大学AMC分校17个部门的临床科学研究人员目前 糖尿病/与糖尿病相关的直接成本赠款支持，个人赠款总额为6500万美元，1400万美元 百万美元的中心和培训补助金。Lori Sussel博士，博士。和医学博士Jane Reusch一起带来了 相互补充的科学背景和专门知识领域，以监督组织和科学重点 加州大学丹佛分校。我们将实施四个生物医学研究核心，以提供尖端技术 在临床资源(用于跟踪研究参与者、生物样本和数据的完全集成的数据库)中， 组织采购和处理(啮齿动物组织和胰岛分离、人胰岛和组织采购、 组织学服务，细胞培养库)，糖尿病建模(人类干细胞-体外细胞和器官来源 模型、基因编辑)以及细胞和组织分析(高级显微镜、流式细胞术、专业 糖尿病社区的CyTOF和MIBI试剂)。加州大学丹佛分校还将建立一个试点项目， 可行性计划，招募年轻教员参与糖尿病和糖尿病相关研究，并鼓励 来自其他领域的成熟研究人员进入糖尿病领域。加州大学丹佛分校院长 医学已经承诺每年补充P&F预算10万美元，以促进糖尿病的增加 在校园里开展研究。最后，加州大学丹佛分校的DRC浓缩项目将促进互动 通过提供研讨会论坛交流研究成果，加州大学AMC的糖尿病研究人员之间， 提供形成协作关系的机会，并鼓励 多样化的糖尿病社区。

CENTER OVERVIEW PROJECT SUMMARY/ABSTRACT The University of Colorado Denver (UC Denver) is world renowned for basic, translational, and clinical diabetes research and treatment of both Type 1 and Type 2 diabetes (T1D and T2D), and their related complications. The proposed University of Colorado Diabetes Research Center (UC Denver DRC) will strengthen diabetes research in Colorado by providing: 1) state-of-the-art research technologies and specialized resources to maximize effective and innovative research; 2) access to patient samples and data; 3) enrichment programs, education and seminar series to the diabetes community; and 4) by attracting new scientists into the diabetes field through the Pilot and Feasibility program. These objectives will be realized by providing improved infrastructure and access to specialized reagents and resources, and an environment that promotes scientific interactions, research discoveries, and progress towards diabetes treatment and cures. The UC Denver DRC will be primarily located on the rapidly growing Anschutz Medical Campus (AMC) in Aurora, Colorado where the majority of the UC Denver clinical and research departments are located. This unique multi-hospital and academic campus configuration allows for a broad diabetes research base, which currently includes 88 basic, translational, and clinical scientific investigators across 17 departments and divisions at UC AMC who currently bring diabetes/diabetes-related direct cost grant support totaling > $65 million in individual grants and >$14 million in center and training grants. Drs. Lori Sussel, PhD. and Jane Reusch, MD bring together complementary areas of scientific backgrounds and expertise to oversee the organization and scientific focus of the UC Denver DRC. We will implement four Biomedical Research Cores to provide cutting-edge technologies in Clinical Resources (fully integrated databases for tracking of study participants, bio-samples and data), Tissue Procurement and Processing (rodent tissue and islet isolation, human islet and tissue procurement, histology services, cell culture bank), Diabetes Modeling (human stem cell-derived in vitro cell and organoid models, gene editing), and Cell and Tissue Analysis (advanced microscopy, flow cytometry, specialized CyTOF and MIBI reagents for the diabetes community). The UC Denver DRC will also establish a Pilot and Feasibility Program to recruit young faculty into diabetes and diabetes-related research, and encourage established investigators from other fields to enter the diabetes field. The Dean of the UC Denver School of Medicine has pledged to supplement the P&F budget by $100,000 each year to promote an increased diabetes research presence on campus. Finally, the UC Denver DRC Enrichment Program will promote the interaction between diabetes researchers at UC AMC by providing seminar forums for exchange of research findings, providing opportunities to form collaborative relationships, and encouraging cross-pollination between the diverse diabetes communities.