Neuronal exosomes in cocaine abuse and treatment response in socially housed monkeys

社会饲养的猴子可卡因滥用和治疗反应中的神经元外泌体

基本信息

  • 批准号:
    10393515
  • 负责人:
  • 金额:
    $ 38.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Cocaine use disorder (CUD) continues to be a major public health and social problem in the United States. A hallmark of CUD is individual differences in vulnerability, relapse and treatment efficacy. Our overall goal is to achieve a better understanding of individual differences in the long-term consequences of the reinforcing effects of cocaine using a unique nonhuman primate model of CUD. We propose to use neuronal-derived exosomes (NDE) in the blood to identify molecular biomarkers associated with an individual's vulnerability to cocaine abuse, susceptibility to relapse following abstinence, and success or failure of targeted therapies for cocaine abuse. Exosomes are nano-vesicles that are released by all cell types. Those released by cells under stressed or pathologic states are different from those released under normal physiologic conditions. Taking advantage of this difference, several exosome-based diagnostic and prognostic biomarkers have been successfully developed. Recent studies have also shown that exosomes in biofluids can be used to establish molecular signatures associated with methamphetamine, heroin, and alcohol abuse. However, exosomes have not been used to understand cocaine abuse – the focus of this application. The proposed study capitalizes on a timely opportunity to use plasma samples from an ongoing NIDA-funded study (R01 DA017763-11; PI: Nader) to understand cocaine abuse in socially housed female and male monkeys. The parent study is testing the efficacy of several pharmacological agents thought to work differently in dominant and subordinate female and male monkeys. All monkeys (socially housed and naturally forming dominant and subordinate hierarchies) are undergoing comprehensive behavioral and cognitive testing, and neuroimaging of central dopamine D2/D3 receptor (D2/D3R) availability using positron emission tomography (PET) imaging. With the costs of key measures covered by existing funding, the availability of plasma samples from these monkeys offers a valuable and cost-effective opportunity to advance our understanding of how exosomes could provide a non- invasive molecular tool to inform us about cocaine abuse and treatment outcomes. Pilot and feasibility data (a) validate our ability to isolate and characterize NDEs from stored plasma samples, and (b) support the utility of NDE biomarkers to understand the molecular effects of cocaine self-administration (SA), and effects of social ranking on cocaine vulnerability and treatment outcomes in male and female monkeys. Thus, we propose two Specific Aims: I. To characterize NDEs associated with cocaine SA in socially housed male and female monkeys. II. To characterize NDEs associated with success or failure of pharmacological agents to decrease cocaine SA in socially housed male and female monkeys. Our results will significantly advance progress toward characterization of non-invasive biomarkers for molecular understanding of cocaine abuse vulnerability and relapse, and contribute in developing a personalized-medicine strategy for treating drug abuse.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Gagan Deep其他文献

Gagan Deep的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Gagan Deep', 18)}}的其他基金

A unique exosome-based approach to identify novel biomarkers for Alzheimer's disease
一种独特的基于外泌体的方法来识别阿尔茨海默病的新型生物标志物
  • 批准号:
    10354433
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)
动脉粥样硬化-细胞外泌体在神经变性和痴呆症中的多种族研究 (MESA-CEND)
  • 批准号:
    10301683
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
MESA-CEND: Promoting diversity in Alzheimer’s disease research
MESA-CEND:促进阿尔茨海默病研究的多样性
  • 批准号:
    10598345
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
Neuronal exosomes in cocaine abuse and treatment response in socially housed monkeys
社会饲养的猴子可卡因滥用和治疗反应中的神经元外泌体
  • 批准号:
    10609495
  • 财政年份:
    2019
  • 资助金额:
    $ 38.75万
  • 项目类别:
Exosomes Promote Disease aggressiveness in African American Prostate Cancer
外泌体促进非裔美国人前列腺癌的疾病侵袭性
  • 批准号:
    8974158
  • 财政年份:
    2015
  • 资助金额:
    $ 38.75万
  • 项目类别:
Development and Characterization of 3D Organoid Lines from Circulating Tumor Cells of African-American Prostate Cancer Patients
非裔美国前列腺癌​​患者循环肿瘤细胞 3D 类器官系的开发和表征
  • 批准号:
    9273217
  • 财政年份:
    2015
  • 资助金额:
    $ 38.75万
  • 项目类别:
Exosomes Promote Disease Aggressiveness in African American Prostate Cancer
外泌体促进非裔美国人前列腺癌的疾病侵袭性
  • 批准号:
    9272480
  • 财政年份:
    2015
  • 资助金额:
    $ 38.75万
  • 项目类别:

相似海外基金

Insula-amygdala circuits in alcohol abuse
酒精滥用中的岛杏仁核回路
  • 批准号:
    10735851
  • 财政年份:
    2023
  • 资助金额:
    $ 38.75万
  • 项目类别:
A novel animal model to study the association between alcohol abuse during late adolescence with common conditions observed in combat Veterans
一种新的动物模型,用于研究青春期后期酗酒与退伍军人中观察到的常见状况之间的关联
  • 批准号:
    10644999
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
Reinforcement as a Prospective Predictor of Real-time Alcohol Abuse Following Bariatric Surgery
强化作为减肥手术后实时酒精滥用的前瞻性预测因子
  • 批准号:
    10370120
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
ACSS2 inhibition in treating Alcohol Abuse
ACSS2 抑制治疗酒精滥用
  • 批准号:
    10546942
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
A novel animal model to study the association between alcohol abuse during late adolescence with common conditions observed in combat Veterans
一种新的动物模型,用于研究青春期后期酗酒与退伍军人中观察到的常见状况之间的关联
  • 批准号:
    10368295
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
Reinforcement as a Prospective Predictor of Real-time Alcohol Abuse Following Bariatric Surgery
强化作为减肥手术后实时酒精滥用的前瞻性预测因子
  • 批准号:
    10705563
  • 财政年份:
    2022
  • 资助金额:
    $ 38.75万
  • 项目类别:
The Functional Implications of Astrocytic GPCR-signaling on Alcohol Abuse
星形胶质细胞 GPCR 信号传导对酒精滥用的功能影响
  • 批准号:
    10472456
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
Trauma and Neurobiological Threat Reactivity as Risk Factors for Alcohol Abuse in Youth
创伤和神经生物学威胁反应作为青少年酗酒的危险因素
  • 批准号:
    10582520
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
Trauma and Neurobiological Threat Reactivity as Risk Factors for Alcohol Abuse in Youth
创伤和神经生物学威胁反应作为青少年酗酒的危险因素
  • 批准号:
    10368089
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
The Functional Implications of Astrocytic GPCR-signaling on Alcohol Abuse
星形胶质细胞 GPCR 信号传导对酒精滥用的功能影响
  • 批准号:
    10089613
  • 财政年份:
    2021
  • 资助金额:
    $ 38.75万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了