A comprehensive intervention to treat emerging drug-using populations

治疗新兴吸毒人群的综合干预措施

• 批准号: 10392901
• 负责人: Hendree E Jones
• 金额: $ 25.42万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392901
• 关键词: 12 year old; 17 year old; Abstinence; Adolescent; Adult; Afghanistan; Aftercare; Age; Anxiety; Assessment tool; Attention; Behavioral; Brain; Cannabis; Child; Child Development; Child Welfare; Childhood; Crime; Data; Development; Disease; Distal; Drug usage; Emotional; Emotional disorder; Family; Female; Goals; HIV risk; India; International; Intervention; Law Enforcement; Lifting; Medical; Mission; Modeling; Narcotic Law; Narcotics; National Institute of Drug Abuse; Operant Conditioning; Opioid; Outcome; Outcome Assessment; Parents; Patients; Pattern; Pharmaceutical Preparations; Pharmacotherapy; Population; Prevalence; Protocols documentation; Provider; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Recording of previous events; Reporting; Research; Research Design; Residential Treatment; Risk Behaviors; Sampling; Social Problems; Societies; Solvents; Substance Use Disorder; Trauma; United Nations; Youth; boys; child services; comparison intervention; data de-identification; design; efficacious intervention; efficacy evaluation; follow-up; girls; implementation intervention; improved; improved outcome; male; marijuana use; opioid use; polysubstance use; post-traumatic symptoms; primary outcome; prospective; psychological distress; reduced substance use; scale up; secondary outcome; social; social cognitive theory; substance use; substance use treatment; therapy development; treatment as usual; treatment duration; treatment program

2.1 Introduction: Children are a critical population to study given the potential for changed brain development due to substance use. Substance use disorders are a pediatric disease and children deserve the same attention as adolescents and adults. This project will examine prospectively collected de-identified data from children receiving drug treatment to inform providers how children can be treated in the USA. In 2011, the Bureau of International Narcotics and Law Enforcement Affairs (INL) of the US Department of State supported the United Nations Office on Drugs and Crime (UNODC) in the development and implementation of an intervention focused on reducing substance use and improving outcomes for children. Dr. Hendree Jones, PI developed the protocols to treat substance use in children (ages 4-17). Results from the 700+ children treated with this early version of our Stopping Use of Narcotics: CHild Intervention to Lift Development (SUN CHILD) intervention indicated that children showed a consistent pattern of significant (all ps<.001) decreases from baseline to post-treatment assessment, with gains maintaining at follow-up in psychiatric disturbance, anxiety-related emotional disorders, social problems, and increases in quality of life. Design: The NIDA-supported part of this study will be to receive and analyze in the USA, the de-identified data from a parallel, two-group, randomized controlled trial in which substance-using (cannabis, solvents, or opioids as the primary drug of use) children 7-12 years of age entering residential treatment randomized to receive either the SUN CHILD intervention (n=272: 204 boys and 68 girls), or usual care (n=272: 204 boys and 68 girls), with the 3:1 male:female ratio of assignment to treatment representing the approximate prevalence of substance use in this population. Outcome assessment instruments will be administered at baseline, post-treatment, and 1-, 3-, 6-, and 12-month post-treatment follow-up. Directly comparing intervention conditions will begin to answer critical questions about the efficacy of reducing cannabis, solvent, and opioid use as well as other substance use and improving the well-being of children. Aims: The main aim is to determine the extent to which the SUN CHILD condition, relative to the usual care condition, shows for the two primary outcomes, (a) longer mean duration of treatment, and (b) greater reductions in mean use of psychoactive substances over the course of post-treatment and 1-, 3-, 6-, and 12-months post-treatment follow-up; and, for the six secondary outcomes, greater reductions in mean (c) HIV risk behaviors, (d) psychiatric disturbance, (e) anxiety-related emotional disorders, (f) social problems, (g) post-traumatic stress symptoms, and larger increases in mean (h) quality of life at post-treatment and 1-, 3-, 6-, and 12-months post-treatment follow-up. The ancillary aim includes understanding the extent to which SUN CHILD is differentially efficacious for (1) girls and boys, (2) younger children v. older children, and (3) examining the relative efficacy of SUN CHILD in children for whom cannabis, solvents, or opioids is the primary drug of choice. Goals: Proximal: To determine the efficacy of the SUN CHILD intervention in terms of the above noted outcomes. Distal: To develop an efficacious intervention to stop substance use among children.

2.1简介：儿童是研究的关键人群，因为药物使用可能会改变大脑发育。物质使用障碍是一种儿科疾病，儿童应该得到与青少年和成人相同的关注。该项目将检查从接受药物治疗的儿童中前瞻性收集的去识别数据，以告知提供者如何在美国治疗儿童。2011年，美国国务院国际麻醉品和执法事务局支持联合国毒品和犯罪问题办公室（毒品和犯罪问题办公室）制定和实施一项干预措施，重点是减少药物使用和改善儿童的成果。Hendree Jones博士，PI制定了治疗儿童（4-17岁）物质使用的方案。来自700多名接受我们的早期版本的停止使用麻醉品治疗的儿童的结果：儿童干预提升发展（SUN CHILD）干预表明，儿童表现出一致的模式，（所有PS<.001）从基线到治疗后评估降低，在精神障碍，焦虑相关的情绪障碍，社会问题，提高生活质量。设计图：本研究的NIDA支持部分将在美国接收和分析来自一项平行、两组、随机对照试验的去识别数据，（大麻、溶剂或阿片类药物作为主要使用药物）进入住院治疗的7-12岁儿童，随机接受SUN CHILD干预（n=272：204名男孩和68名女孩）或常规护理（n=272：204名男孩和68名女孩），分配治疗的男女比例为3：1，代表了该人群中药物使用的大致流行率。将在基线、治疗后以及治疗后1个月、3个月、6个月和12个月随访时使用结局评估工具。直接比较干预条件将开始回答有关减少大麻，溶剂和阿片类药物使用以及其他物质使用和改善儿童福祉的有效性的关键问题。目的：主要目的是确定SUN CHILD条件相对于常规护理条件显示两个主要结局的程度，（a）更长的平均治疗持续时间，和（B）治疗后和治疗后1、3、6和12个月随访期间精神活性物质平均使用量的更大减少;对于6个次要结局，平均（c）HIV风险行为，（d）精神障碍，（e）焦虑相关情绪障碍，（f）社会问题，（g）创伤后应激症状的降低幅度更大，平均（h）治疗后和1-，治疗后3个月、6个月和12个月随访。辅助目的包括了解SUN CHILD对（1）女孩和男孩，（2）年幼儿童与年长儿童的差异有效程度，以及（3）检查SUN CHILD在大麻、溶剂或阿片类药物为主要药物选择的儿童中的相对疗效。目标：近端：确定SUN CHILD干预措施在上述结局方面的有效性。远端：制定有效的干预措施，以阻止儿童使用药物。

项目成果

Comprehensive Treatment for Pregnant and/or Parenting Women with Substance Use Disorders and Their Children: A Cross-Cultural Comparison.

• DOI: pii: 1085
• 发表时间: 2021
• 期刊: Journal of substance abuse and alcoholism
• 作者: Jones E H;Klaman L S;Leiner C;da Silva Barros R;Canay R;Suarez V J;Ordoñez M RS;O'Grady E K
• 通讯作者: O'Grady E K

Risk Factors for Substance Use Among Street Children Entering Treatment in India.

印度街头儿童接受治疗的药物使用风险因素。

• DOI: 10.4103/0253-7176.191375
• 发表时间: 2016
• 期刊: Indian journal of psychological medicine
• 影响因子: 2.8
• 作者: Bhattacharjee,Shibendu;Kumar,Rajesh;Agrawal,Alok;O'Grady,KevinE;Jones,HendréeE
• 通讯作者: Jones,HendréeE

Implementation and Evaluation of an Intervention for Children in Afghanistan at Risk for Substance Use or Actively Using Psychoactive Substances.

• DOI: 10.1155/2017/2382951
• 发表时间: 2017
• 期刊: International journal of pediatrics
• 影响因子: 2.1
• 作者: Momand AS;Mattfeld E;Morales B;Ul Haq M;Browne T;O'Grady KE;Jones HE
• 通讯作者: Jones HE

The CHILD Intervention for Living Drug-free Comprehensive Assessment of Risk, Resilience, and Experience (CHILD CARRE) Measure: Initial Findings.

对风险、复原力和经验进行无毒品生活综合评估的儿童干预 (CHILD CARRE) 措施：初步发现。

• DOI: 10.1080/1067828x.2020.1766621
• 发表时间: 2019
• 期刊: Journal of child & adolescent substance abuse
• 影响因子: 0.6
• 作者: Jones,HendréeE;Momand,AbdulSsubor;Morales,Brian;Browne,Thom;Poliansky,Nicolas;Ruiz,Diego;Aranguren,Mercedez;Sanchez,Silvina;Fratto,Valeria;O'Grady,KevinE
• 通讯作者: O'Grady,KevinE

Increasing Substance Use Disorder Treatment Professionals Knowledge: The Child Intervention for Living Drug-free (CHILD) Curriculum.

• DOI: pii: 1086
• 发表时间: 2021
• 期刊: Journal of substance abuse and alcoholism
• 作者: Jones HE;Momand AS;Lensch AC;Browne T;Morales B;O'Grady KE
• 通讯作者: O'Grady KE