Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease

社区健康中心：解决马里兰州地区疾病的环境决定因素

• 批准号: 10394475
• 负责人: Marsha Wills-Karp
• 金额: $ 140.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-24 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394475
• 关键词: Address; Affect; Allergens; Animal Feed; Attention; Baltimore; Big Data; Bioinformatics; Biological; Biometry; Chemicals; Cities; Climate; Clinical; Communication; Communities; Community Health; Core Facility; Data; Decision Making; Development; Discipline; Disease; District of Columbia; Educational workshop; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exposure to; Faculty; Federal Government; Fostering; Funding; Future; Gases; Health; Health Policy; Health Promotion; Health Sciences; Human; In Vitro; Individual; Industrialization; Industry; Investigation; Knowledge; Leadership; Link; Local Government; Maryland; Mentors; Metals; Mission; Modeling; NCI Scholars Program; National Institute of Environmental Health Sciences; Natural Gas; Neighborhood Health Center; Neurologic; Outcome; Particulate; Pennsylvania; Personal Satisfaction; Policies; Polychlorinated Biphenyls; Population; Population Study; Positioning Attribute; Predisposition; Prevention; Production; Public Health; Public Health Practice; Research; Research Design; Research Personnel; Risk Assessment; Science; Scientist; Source; Strategic Planning; Strategic vision; Structure; Time; Training; Translating; Translational Research; Translations; Universities; Urban Developments; Washington; adverse outcome; built environment; cardiorespiratory fitness; career development; cohort; college; community engaged research; community engagement; data to knowledge; disorder prevention; environmental justice; evidence base; health science research; human subject; improved; in vivo; laboratory equipment; member; metabolomics; multidisciplinary; nervous system disorder; response; skills; social; translational pipeline; vapor; vulnerable community

ABSTRACT (OVERALL) The Johns Hopkins University (JHU) proposes the creation of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Diseases (CHARMED). The strategic vision of the Center is to serve as the nexus of community-engaged environmental research at JHU and in the Maryland region (Washington DC, Baltimore (referred to as CHARM City) and Pennsylvania) by providing focus, research, and leadership for promotion of transformative environmental health science research that will improve human health. The overarching mission is to understand how exposures to environmental factors cause adverse health outcomes and then to translate these findings into action to protect and promote the health and well-being of vulnerable communities in the Maryland region. This mission has been informed by and will continue to be guided by strong partnerships between community leaders and CHARMED members (59) drawn from the JHU and the University of Maryland at College Park. The synergistic combination of basic, population and community- engagement scientists within CHARMED promotes translational research that addresses fundamental questions and translates knowledge into action to have a major impact on human health in the Maryland region, consistent with the NIEHS Strategic Plan. Our mission is accomplished through five aims. Aim 1: Advance translational environmental health research that will improve community health outcomes in the Maryland region as it relates to the thematic foci of the Center. The Thematic Research Groups are: 1) Cardiorespiratory Health and Airborne Contaminants; 2) Chemical Mixtures and Emerging Contaminants, and Health; 3) Community, Social, and Environmental Determinants of Health; and 4) Neurological Health. Aim 2. Promote translation of data to knowledge to action by creating and strengthening strategic partnerships with communities and stakeholders to address environmental health challenges and help set the research agenda of CHARMED using community- engaged research approaches (Community Engagement Core). Aim 3. Establish and support a facility core structure [Integrated Health Sciences Facility Core (IHSFC), and Exposure Characterization and Modeling Facility Core (ECMC)] that enables the mission. The IHSFC will provide assistance with human subject study design, and employ biostatistical, big data, and bioinformatic analyses and integrate “omics” including metabolomics data to predict adverse outcomes. Aim 4. Build capacity in environmental health through a comprehensive strategy that includes fostering (career development, Core Workshops), and supporting (ESI Mentored Scholars Program, pilot funds, access to facility cores) both early stage and senior investigators conducting community environmental health research for the first time. Harnessing the scientific capacity of the Center will facilitate translation of the Center’s research findings into evidence-based approaches for environmental exposure mitigation and disease prevention to improve human health in Maryland and beyond.

摘要（总体） 约翰霍普金斯大学 (JHU) 提议创建社区健康中心：解决 马里兰州地区疾病环境决定因素 (CHARMED)。中心的战略愿景 是约翰霍普金斯大学和马里兰地区社区参与环境研究的纽带 （华盛顿特区、巴尔的摩（简称“魅力城”）和宾夕法尼亚州）通过提供焦点、研究和 领导促进变革性环境健康科学研究，以改善人类健康。 首要任务是了解暴露于环境因素如何导致不良健康 结果，然后将这些发现转化为行动，以保护和促进人们的健康和福祉 马里兰州地区的弱势社区。该任务已获通知并将继续受其指导 通过社区领袖和来自 JHU 和 马里兰大学学院公园分校。基础、人口、社区协同结合 CHARMED 内的科学家参与促进解决基本问题的转化研究 并将知识转化为行动，对马里兰州地区的人类健康产生重大影响，始终如一 与 NIEHS 战略计划。我们的使命是通过五个目标来实现的。目标 1：推进转化 环境健康研究将改善马里兰州地区的社区健康成果 中心的专题重点。专题研究小组包括： 1) 心肺健康和空气传播 污染物； 2) 化学混合物和新兴污染物以及健康； 3) 社区、社会和 健康的环境决定因素； 4) 神经系统健康。目标 2. 促进数据转化 通过建立和加强与社区和利益相关者的战略伙伴关系，将知识转化为行动 解决环境健康挑战并利用社区帮助制定 CHARMED 研究议程 参与的研究方法（社区参与核心）。目标 3. 建立并支持设施核心 结构 [综合健康科学设施核心 (IHSFC)，以及暴露特征描述和建模 实现该任务的设施核心（ECMC）]。 IHSFC 将提供人类受试者研究协助 设计并采用生物统计学、大数据和生物信息学分析并整合“组学”，包括 预测不良结果的代谢组学数据。目标 4. 通过以下方式建设环境健康方面的能力： 全面的战略，包括培养（职业发展、核心研讨会）和支持（ESI 导师学者计划、试点资金、使用设施核心）早期和高级研究人员 首次开展社区环境健康研究。利用科学能力 中心将促进将中心的研究成果转化为基于证据的方法 减轻环境暴露和预防疾病，以改善马里兰州及其他地区的人类健康。