Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease

摘要（总体） 约翰霍普金斯大学（JHU）建议建立社区卫生中心： 区域马里兰州疾病的环境决定因素（CHARMED）。中心的战略愿景 是作为JHU和马里兰州地区社区参与环境研究的纽带 （华盛顿特区、巴尔的摩（简称CHARM城）和宾夕法尼亚州）通过提供重点、研究和 领导促进变革性的环境健康科学研究，将改善人类健康。 首要的使命是了解暴露于环境因素如何导致不良健康 结果，然后将这些发现转化为行动，以保护和促进健康和福祉， 马里兰州地区的弱势群体。这一使命得到了并将继续得到 通过社区领导人和CHARMED成员（59）之间的强有力的伙伴关系，从JHU和 马里兰州大学帕克分校。基础、人口和社区的协同结合- CHARMED内部的参与科学家促进解决基本问题的转化研究 并将知识转化为行动，对马里兰州地区的人类健康产生重大影响， NIEHS战略计划。我们的使命通过五个目标来完成。目标1：推进翻译 环境健康研究，将改善社区健康成果在马里兰州地区，因为它涉及 中心的主题焦点。专题研究小组包括：1）呼吸系统健康和空气传播 污染物; 2）化学混合物和新出现的污染物，以及健康; 3）社区，社会和 健康的环境决定因素; 4）神经健康。目标二。促进数据转换， 通过建立和加强与社区和利益攸关方的战略伙伴关系， 解决环境健康的挑战，并帮助制定研究议程的CHARMED使用社区- 社区参与核心（Community Engagement Core）。目标3。建立和支持设施核心 结构[综合健康科学设施核心（IHSFC），以及暴露表征和建模 设施核心（ECMC）]，使使命。IHSFC将为人类受试者研究提供帮助 设计和使用生物统计学、大数据和生物信息学分析，并整合“组学”，包括 代谢组学数据来预测不良结果。目标4。通过环境卫生能力建设， 包括培养（职业发展、核心研讨会）和支持（ESI）的综合战略 指导学者计划、试点基金、获得设施核心），包括早期和高级研究人员 首次开展社区环境卫生研究。利用联合国的科学能力 中心将促进将中心的研究成果转化为循证方法， 环境暴露缓解和疾病预防，以改善马里兰州及其他地区的人类健康。

ABSTRACT (OVERALL) The Johns Hopkins University (JHU) proposes the creation of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Diseases (CHARMED). The strategic vision of the Center is to serve as the nexus of community-engaged environmental research at JHU and in the Maryland region (Washington DC, Baltimore (referred to as CHARM City) and Pennsylvania) by providing focus, research, and leadership for promotion of transformative environmental health science research that will improve human health. The overarching mission is to understand how exposures to environmental factors cause adverse health outcomes and then to translate these findings into action to protect and promote the health and well-being of vulnerable communities in the Maryland region. This mission has been informed by and will continue to be guided by strong partnerships between community leaders and CHARMED members (59) drawn from the JHU and the University of Maryland at College Park. The synergistic combination of basic, population and community- engagement scientists within CHARMED promotes translational research that addresses fundamental questions and translates knowledge into action to have a major impact on human health in the Maryland region, consistent with the NIEHS Strategic Plan. Our mission is accomplished through five aims. Aim 1: Advance translational environmental health research that will improve community health outcomes in the Maryland region as it relates to the thematic foci of the Center. The Thematic Research Groups are: 1) Cardiorespiratory Health and Airborne Contaminants; 2) Chemical Mixtures and Emerging Contaminants, and Health; 3) Community, Social, and Environmental Determinants of Health; and 4) Neurological Health. Aim 2. Promote translation of data to knowledge to action by creating and strengthening strategic partnerships with communities and stakeholders to address environmental health challenges and help set the research agenda of CHARMED using community- engaged research approaches (Community Engagement Core). Aim 3. Establish and support a facility core structure [Integrated Health Sciences Facility Core (IHSFC), and Exposure Characterization and Modeling Facility Core (ECMC)] that enables the mission. The IHSFC will provide assistance with human subject study design, and employ biostatistical, big data, and bioinformatic analyses and integrate “omics” including metabolomics data to predict adverse outcomes. Aim 4. Build capacity in environmental health through a comprehensive strategy that includes fostering (career development, Core Workshops), and supporting (ESI Mentored Scholars Program, pilot funds, access to facility cores) both early stage and senior investigators conducting community environmental health research for the first time. Harnessing the scientific capacity of the Center will facilitate translation of the Center’s research findings into evidence-based approaches for environmental exposure mitigation and disease prevention to improve human health in Maryland and beyond.