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The role of breast cancer organ specific metastasis on the therapeutic impact of anti-cancer drugs

乳腺癌器官特异性转移对抗癌药物治疗影响的作用

基本信息

批准号：
10394810
负责人：
Giulio Francia
金额：
$ 37.75万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10394810
关键词：
Antineoplastic Agents Biology Brain Breast Cancer Cell Breast Cancer Model Breast Cancer Patient Breast cancer metastasis Cancer Model Cause of Death Cells Cessation of life Classification Clinical Trials Cytotoxic T-Lymphocytes Data Development Diagnosis Disease Exhibits Growth Human Immune system Immunodeficient Mouse Impact evaluation Injections Integration Host Factors Lead Literature Liver Liver diseases Location Lung Metastatic Neoplasm to the Liver Metastatic Neoplasm to the Lung Metastatic breast cancer Modeling Mus Neoplasm Metastasis Organ Paclitaxel Patient Selection Patients Pattern Pharmaceutical Preparations Population Pre-Clinical Model Predisposition Raman Spectrum Analysis Randomized Regimen Role Site Solid Neoplasm Testing Therapeutic Time Transgenic Organisms Translating United States Visceral Woman Work arm base cancer cell chemotherapy effective therapy gemcitabine improved individualized medicine innovation laser capture microdissection malignant breast neoplasm mouse model neoplastic cell novel novel strategies pre-clinical response therapeutically effective transcriptome treatment optimization treatment response tumor tumor growth

项目摘要

PROJECT SUMMARY Every year breast cancer causes the death of around 40,000 women in the United States, highlighting the need to improve the options to treat this disease. This proposal focuses on late stage breast cancer, where the cancer cells have spread (metastasized), and for which the median survival is approximately 3 years from the time of diagnosis. We will test whether the location of breast cancer spread – which can include the liver, the lung, and brain – alters the sensitivity of the breast cancer cells to chemotherapy. In Specific Aim 1, we will establish models of breast cancer metastases to different sites and then test the relative response to chemotherapeutic drugs. In Specific Aim 2, we will explore the extent to which host factors, including host immune system cells, can alter the pattern of dissemination of breast cancer metastases and their response to chemotherapy. Our hypothesis is that breast cancer metastasis to different organs results in organ-dependent sensitivity of the tumor cells to anti-cancer agents. Overall this project will explore the extent to which the location of a breast cancer metastasis can determine its sensitivity to available drugs. The testing of our hypothesis could lead to more effective therapeutic strategies – those that are tailored to the location of the metastases. Optimizing therapy in such a way should improve the efficacy of available therapies leading to increased overall survival time of patients with breast cancer.

项目摘要在美国，每年乳腺癌导致大约40，000名妇女死亡。强调需要改进治疗这种疾病的选择。这项建议重点关注晚期乳腺癌，癌细胞已经扩散，（转移），中位生存期约为3年，诊断时间。我们将测试乳腺癌的位置是否扩散-这可以包括肝脏，肺和大脑-改变了乳腺癌细胞对化疗在具体目标1中，我们将建立乳腺癌转移到不同部位的模型然后检测对化疗药物的相对反应。在具体目标2中，将探索宿主因素，包括宿主免疫系统细胞，改变乳腺癌转移的扩散模式及其对化疗我们的假设是乳腺癌转移到不同的器官导致肿瘤细胞对抗癌剂的器官依赖性敏感性。整体该项目将探索乳腺癌转移的位置在多大程度上可以确定其对现有药物的敏感性。对我们假设的检验可能会导致到更有效的治疗策略-那些适合的位置，转移以这种方式优化治疗应该提高现有治疗的疗效。乳腺癌患者的总体生存时间增加的治疗。