Coordinating an ACE studying IgG4-related diseases

项目摘要 这一行政核心将协调三项职能。作为第一个功能的一部分，它将提供帮助 协调主要项目、合作项目和试点项目。在固定的时间 在每个月的第一个星期一，项目协调员和调查人员以及 三个项目的调查人员将在马萨诸塞州面对面或通过电话会议进行会面 综合医院绘制进度图，协调研究和样本收集。这些 会议将在目前正在举行的每月定期会议的基础上扩大。第二个目标 这一核心将是向其他人提供人类免疫学研究的工具 麻省理工学院研究lgG4相关疾病以外的自身免疫性疾病的研究人员 包括用于曲目的下一代测序，研究免疫细胞的专业知识和 深度组织、细胞存储和剖析技术。ACE计划协调员将 定期通知更广泛的MGH社区每月会议的时间和地点 首席调查员将留出一个小时会见临床医生和其他 寻求互动的麻省理工学院的调查人员。这些互动还将促进一些 关于IgG4相关疾病和系统性硬化症病因的主要项目研究。 该核心及其协调者的第三个目标将是生成用于与 其他王牌并分享有关免疫谱系、微生物群落的信息 特征和染色质数据与全国各地的其他组织合作 自身免疫，不一定局限于其他王牌。

Project Summary This Administrative Core will mediate three functions. As part of the first function it will help coordinate the Principal Project, the Collaborative Project and the Pilot Project. At a fixed time on the first Monday of every month the project coordinator and the Investigators and Co- investigators of the three projects will meet face to- face or by conference call at Massachusetts General Hospital to chart progress and coordinate studies and sample collection. These meetings will expand on ongoing regular monthly meetings currently being held. A second goal of this Core will be to make available tools of Human Immunology research to other investigators at MGH studying autoimmune disorders other than lgG4-Related Disease including Next Gen sequencing for repertoire, expertise with investigating immune cells and tissues in depth, cell storage and profiling techniques. The ACE program coordinator will regularly inform the broader MGH community of the time and location of the monthly meetings and an hour will be set aside by the Principal Investigator to meet clinicians and other investigators at the MGH who seek to interact. These interactions will also facilitate some of the studies of the Principal Project on the causes of IgG4 related disease and systemic sclerosis. The third goal of this Core and its coordinator will be to generate a portal for interaction with other ACEs and to share information on Immune repertoires, microbial community characteristics and chromatin data with other groups working across the country on autoimmunity, not necessarily restricted to other ACEs.