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Inducing neutralizing antibodies to HIV by inhibiting SIAE

Inducing neutralizing antibodies to HIV by inhibiting SIAE
通过抑制 SIAE 诱导 HIV 中和抗体
批准号：
8089346
负责人：
SHIV Subramaniam PILLAI
金额：
$67.15万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-06-15 至 2014-05-31
来源：
https://reporter.nih.gov/project-details/8089346
关键词：
AcetylesteraseAutoantigensB-Cell ActivationB-LymphocytesEnzymesEpitopesGenerationsGenesHIVHIV Envelope Protein gp120HumanMusPeripheralSialic AcidsVaccinationabstractingesteraseknock-downmutantneutralizing antibodynovel strategiesprevent

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英文摘要
DESCRIPTION (provided by applicant): Abstract: The enzyme Sialic acid acetylesterase maintains peripheral B cell tolerance and prevents the activation of B cells that see self antigens weakly. This enzyme is of relevance in both murine and human B cells. Inhibiting this esterase may permit the activation of B cells that see conserved but weak epitopes on HIV gp120. The SIAE gene will be knocked down in humanized mice. Both SIAE knockdown humanized mice and Siae mutant conventional mice will be immunized with gp140 trimers in an attempt to ask if inhibition of SIAE favors the generation of neutralizing antibodies against HIV. A novel strategy for HIV vaccination is proposed, that may permit the induction of protective neutralizing antibodies.
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