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Inducing neutralizing antibodies to HIV by inhibiting SIAE

Inducing neutralizing antibodies to HIV by inhibiting SIAE
通过抑制 SIAE 诱导 HIV 中和抗体
批准号：
8291408
负责人：
SHIV Subramaniam PILLAI
金额：
$90.46万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-06-15 至 2014-05-31
来源：
https://reporter.nih.gov/project-details/8291408
关键词：
AcetylesteraseAntibody AffinityAutoantigensAvidityB cell repertoireB-Cell ActivationB-LymphocytesBindingCD22 geneEnzymesEpitopesGenerationsGenesHIVHIV Envelope Protein gp120HIV envelope proteinHumanImmune responseImmunizationImmunoglobulin Somatic HypermutationLectinMusMutant Strains MicePeripheralProcessSialic AcidsTestingV(D)J RecombinationVaccinationabstractingbaseesteraseimmunogenicknock-downmutantneutralizing antibodynovel strategiespreventresponsesialic acid binding Ig-like lectinsmall hairpin RNA

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DESCRIPTION (provided by applicant): Abstract: The enzyme Sialic acid acetylesterase maintains peripheral B cell tolerance and prevents the activation of B cells that see self antigens weakly. This enzyme is of relevance in both murine and human B cells. Inhibiting this esterase may permit the activation of B cells that see conserved but weak epitopes on HIV gp120. The SIAE gene will be knocked down in humanized mice. Both SIAE knockdown humanized mice and Siae mutant conventional mice will be immunized with gp140 trimers in an attempt to ask if inhibition of SIAE favors the generation of neutralizing antibodies against HIV.
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