RII-Track 1: New Hampshire Center for Multiscale Modeling and Manufacturing of Biomaterials (NH Bio-Made)

RII-Track 1：新罕布什尔州生物材料多尺度建模和制造中心 (NH Bio-Made)

• 批准号: 1757371
• 负责人: Brad Kinsey
• 金额: $ 2000万
• 依托单位: University of New Hampshire
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757371&HistoricalAwards=false
• 关键词: RII; Track; New; Hampshire; Center

Non-technical DescriptionThe New Hampshire Center for Multiscale Modeling and Manufacturing of Biomaterials (NH Bio-Made) promises to create new knowledge and drive technological innovation, and train workforce in the areas of biotechnology and advanced manufacturing. The project's activities are organized around an integrated design approach that connects computational modeling, advanced manufacturing, and measurement of materials properties, all oriented toward developing new materials for biomedical applications such as orthopedic bearings and tissue engineering scaffolds. The integrated approach is intended to encourage close collaboration across disciplines to drive biomaterials development. The project will also include major investments in New Hampshire's research capacity. NH Bio-Made will establish a shared Biomaterials Core Facility to provide access to state-of the-art instrumentation and cyberinfrastructure for researchers statewide, and will support the hiring of eleven new faculty researchers at institutions across the state. The project's research activities will be integrated with an ambitious workforce development agenda aimed at providing diverse students with the specific biomaterials and manufacturing skills needed to enable their career success. These efforts will emphasize training for students in high schools, community colleges, and at institutions of higher learning in NH and will be directed toward careers in the biotechnology sector.Technical DescriptionNH Bio-Made's goal is to advance the design and manufacture of hierarchical, heterogeneous biomaterials and enable the knowledge to predict and control their composition, structure, properties, and function. To accomplish this, the project will develop computational tools that span materials spatial scales from atomic to the macroscale. It will combine bottom-up self-assembly with top-down 3D printing to create biomaterials with designed structure at the nanoscale. These activities will employ a systems-level approach that drives hierarchical, heterogeneous biomaterial design for highly specific and verifiable functionalities. Research activities will be organized into four major thrusts, each working towards the development of specific categories of biomaterials: 1) composites for orthopedic bearings; 2) sheet metal for trauma fixation; 3) tissue engineering scaffolds; and 4) porous, conductive biosensors. These efforts will be supported by the Biomaterials Core Facility that will provide researchers across the state with shared access to high-performance computing infrastructure, advanced manufacturing equipment, and materials characterization instrumentation. The expectation is that the NH Bio-Made will advance understanding of new the design and manufacture of advanced materials while accelerating the state's competitiveness in the growing and important biotechnology industry. To ensure broad benefits from these research and infrastructure investments, the project will also provide training for students preparing to enter the biomaterials and advanced manufacturing workforce. These efforts will include both work-based learning opportunities for high school and community college students moving into the workforce and programs to facilitate the transition for students choosing to continue their education.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术性描述新罕布什尔州生物材料多尺度建模和制造中心（NH Bio-Made）承诺创造新知识，推动技术创新，并培训生物技术和先进制造领域的劳动力。该项目的活动是围绕一个集成的设计方法，连接计算建模，先进制造和材料性能的测量，所有面向开发新材料的生物医学应用，如骨科轴承和组织工程支架。这种综合方法旨在鼓励跨学科的密切合作，以推动生物材料的开发。该项目还将包括对新罕布什尔州研究能力的重大投资。NH Bio-Made将建立一个共享的生物材料核心设施，为全州的研究人员提供最先进的仪器和网络基础设施，并将支持在全州各机构雇用11名新的教职研究人员。该项目的研究活动将与雄心勃勃的劳动力发展议程相结合，旨在为不同的学生提供使其职业成功所需的特定生物材料和制造技能。这些努力将强调在高中，社区学院和高等院校的学生在NH的培训，并将在生物技术sect.Technical Description NH Bio-Made的目标是推进设计和制造的分层，异质生物材料，使知识来预测和控制其组成，结构，性能和功能的职业生涯。为了实现这一目标，该项目将开发计算工具，从原子到宏观尺度跨越材料空间尺度。它将联合收割机自下而上的自组装与自上而下的3D打印相结合，以创造具有纳米级设计结构的生物材料。这些活动将采用系统级方法，推动分层，异质生物材料设计，以实现高度特异性和可验证的功能。研究活动将分为四个主要方向，每个方向都致力于开发特定类别的生物材料：1）骨科轴承复合材料; 2）创伤固定金属板; 3）组织工程支架; 4）多孔导电生物传感器。这些努力将得到生物材料核心设施的支持，该设施将为全州的研究人员提供共享高性能计算基础设施、先进制造设备和材料表征仪器的机会。预计NH Bio-Made将促进对新材料的理解，设计和制造先进材料，同时加速该州在不断增长的重要生物技术产业中的竞争力。为了确保从这些研究和基础设施投资中获得广泛利益，该项目还将为准备进入生物材料和先进制造业的学生提供培训。这些努力将包括为高中和社区大学的学生进入劳动力市场提供以工作为基础的学习机会，以及促进选择继续接受教育的学生过渡的计划。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Micromechanical origins of remarkable elongation-to-fracture in AHSS TRIP steels via continuous bending under tension

• DOI: 10.1016/j.msea.2021.141876
• 发表时间: 2021-09
• 期刊: Materials Science and Engineering A-structural Materials Properties Microstructure and Processing
• 影响因子: 6.4
• 作者: Rishabh Sharma;C. Poulin;M. Knezevic;M. Miles;D. Fullwood

Evolution of microstructure and strength of a high entropy alloy undergoing the strain-induced martensitic transformation

• DOI: 10.1016/j.msea.2023.145754
• 发表时间: 2023-11
• 期刊: Materials Science and Engineering: A
• 作者: Jacob Weiss;D. J. Savage;Sven C. Vogel;Brandon A. McWilliams;R. Mishra;Marko Knezevic

Gas‐Induced Electrical and Magnetic Modulation of Two‐Dimensional Conductive Metal−Organic Framework

二维导电金属有机框架的气体感应电和磁调制

• DOI: 10.1002/ange.202404290
• 发表时间: 2024
• 期刊: Angewandte Chemie
• 作者: Meng, Zheng;Stolz, Robert M.;De Moraes, Lygia Silva;Jones, Christopher G.;Eagleton, Aileen M.;Nelson, Hosea M.;Mirica, Katherine A.
• 通讯作者: Mirica, Katherine A.

Fast-Curing Injectable Microporous Hydrogel for In Situ Cell Encapsulation.

• DOI: 10.1021/acsabm.2c00214
• 发表时间: 2022-06-20
• 期刊: ACS APPLIED BIO MATERIALS
• 影响因子: 4.7
• 作者: Edwards, Seth D;Hou, Shujie;Brown, Jason M;Boudreau, Ryann D;Lee, Yuhan;Kim, Young Jo;Jeong, Kyung Jae
• 通讯作者: Jeong, Kyung Jae

Tuning Shear Thinning Factors of 3D Bio-Printable Hydrogels Using Short Fiber.

• DOI: 10.3390/ma16020572
• 发表时间: 2023-01-06
• 期刊: MATERIALS
• 影响因子: 3.4
• 作者: Tuladhar, Slesha;Clark, Scott;Habib, Ahasan
• 通讯作者: Habib, Ahasan