Exposure Science Facility

项目摘要-曝光科学设施(ESF) 暴露科学机构(ESF)的主要目标是促进EHSRC的研究工作 调查人员试图了解对结果产生不利影响的外部环境应激源 在曝光之后。ESF通过以下具体目标实现这一目标：目标1)提供 用于空气污染物建模和暴露评估的资源和专门知识；目标2)支持 EHSRC主题领域、试点研究、CEC活动和指导准成员；目标3)促进 EHSRC调查人员的多学科研究；目标4)提供专业知识，并促进 在暴露评估和以健康为基础的调查的连续统一体中的互动；以及目标5)促进 博士后、博士后和准会员在建模和接触评估方法方面的培训。 ESF由一组在其广泛方面拥有长期专业知识的调查人员提供支持 目标，包括环境污染物采样、工业卫生做法、健康物理学、空气方面的专门知识 弥散模型、计算流体动力学模型和化学分析方法 接触途径。ESF在EHSRC内发挥关键作用，协助各级和 试点赠款接受者，以适当识别、量化和建模环境污染物，并量化风险。 ESF努力开发和维护仪器和建模能力，以帮助调查人员 将环境污染物与健康结果联系起来。因此，英基对以下方面至为重要 EHSRC的研究人员试图了解人类健康和癌症之间的复杂联系 曝光。ESF通过收集最先进的仪器和实验室来实现其目标。 加在一起，它们还包括用于采样气体、蒸气和气溶胶的各种仪器。 到那些能够分析复杂基质中的各种化合物的人，包括水，食物，空气， 血液和组织样本。ESF建模功能包括用于确定空间分布的功能 空气污染物和颗粒物在人类肺部的沉积。ESF领导层教职员工提供 为EHSRC调查员提供咨询和培训，以规划涉及评估的研究项目 环境暴露对人类健康的影响。ESF是爱荷华大学校园内独一无二的设施 与其中央设施有很强的关联性。再加上这些设施和它的乐器收藏 和相关支持，ESF允许EHSRC调查人员在征集资金时编制具有成本效益的预算 为他们的研究提供外部资金。

PROJECT SUMMARY - EXPOSURE SCIENCE FACILITY (ESF) The primary goal of the Exposure Science Facility (ESF) is to facilitate the research efforts of EHSRC investigators as they seek to understand the external environmental stressors that adversely affect outcomes following an exposure. The ESF addresses this goal through the following specific aims: Aim 1) Provide resources and expertise for modeling of airborne contaminants and exposure assessment; Aim 2) support EHSRC Thematic Areas, pilot studies, CEC activities, and mentored Associate Members; Aim 3) facilitate multidisciplinary research among EHSRC investigators; Aim 4) provide expertise, as well as facilitate interaction, in the continuum of exposure assessment and health-based investigation; and Aim 5) facilitate pre-doctoral, post-doctoral and Associate Member training in modeling and exposure assessment methods. The ESF is supported by a team of investigators with longstanding expertise in the wide-ranging aspects of its Aims, including expertise in environmental pollutant sampling, industrial hygiene practices, health physics, air dispersion modeling, computational fluid dynamics modeling, and chemical analytical methods related to all routes of exposure. The ESF provides a critical role within the EHSRC by aiding investigators at all levels and pilot grant recipients to properly identify, quantify and model environmental contaminants, and quantify risk. The ESF strives to develop and maintain instrumentation and modeling capabilities, which help investigators link environmental contaminants with health outcomes. The ESF is therefore of fundamental importance to EHSRC investigators as they seek to understand the complicated linkages between human health and the exposome. The ESF achieves its goals through its collection of state-of-the-art instruments and laboratories. Combined, they include a wide variety of instruments used to sample gases, vapors, and aerosols in addition to those capable of analyzing various chemical compounds in complex matrices, including water, food, air, blood, and tissue samples. ESF modeling capabilities include those used to determine the spatial distribution of air pollutants and the deposition of particles in the human lung. ESF leadership faculty and staff provide consultation and training to EHSRC investigators planning research projects involving the assessment of environmental exposures on human health. The ESF is a unique facility on the University of Iowa campus that has strong associations with its central facilities. Together with these facilities and its collection of instruments and related support, the ESF allows EHSRC investigators to prepare cost-effective budgets when soliciting extramural funds for their research.